• Tuesday, March 16
  • 10:00 am - 11:00 am
  • Conference Success Tips and Welcome from the Early Career Leadership Program
  • Session Chair:
  • Jessica Velez, GSA
The purpose of this event is to help conference attendees make the most of the conference. Topics covered may include: introduction to organizers of the meeting, advice on having meaningful interactions in a virtual space, a chance to meet other attendees in an informal setting, and an introduction to events in the scientific and other programming.
  • Tuesday, March 16
  • 11:00 am - 12:00 pm
  • How to get involved in GSA's Early Career Leadership Program
  • Session Chair:
  • Jessica Velez, GSA
GSA Early Career Leadership Program members will join us in sharing how to get involved in the ECLP focusing on how the program has advanced their scientific skill sets and careers. GSA will walk through how and when to apply and showcase programming Early Career Scientists can participate in throughout the year.

For undergrads, grads and postdocs.
  • Tuesday, March 16
  • 1:00 pm - 3:00 pm
  • Career Exploration Panel
  • Session Chair:
  • Molly Matty, Salk Institute for Biological Sciences
This event for graduate students and postdocs will show the broad options available to those with a PhD by hosting a panel of individuals from multiple career paths. The career sectors highlighted will be: academic research, government research, science communication and writing, science policy, non-profit, business, outreach, and academic administration.

 
  • Wednesday, March 17
  • 12:30 pm - 2:00 pm
  • Careers in Academia
  • Session Chair:
  • Karen Hales, Davidson College

This ninety-minute discussion panel will feature department heads and academic faculty who will discuss applying and hiring in academia from both sides of the process, as well as provide insight into an academic career.


 
  • Wednesday, March 17
  • 3:00 pm - 5:00 pm
  • Reproducibility for Everyone
  • Session Chairs:
  • Nele Haelterman, Baylor College of Medicine
  • Nafisa Jadavji, Midwestern University
Organizers: N. Haelterman, N. Jadavji

Rigor and reproducibility are at the core of modern science and set apart scientific inquiry from pseudoscience. Several new initiatives and tools have been established to address barriers to reproducibility. While very welcome, these projects have led to a proliferation of online tools and resources which can be hard to sift through. This workshop will introduce you to reproducible workflows and a range of tools for the organization, documentation, analysis, and dissemination of scientific data. After a brief introduction on the topic of reproducibility, the workshop will provide specific tips and tools useful in improving your daily research workflows. This will include the 101 of all data handling, wet lab protocol sharing platforms, documentation of code using notebooks, workflow systems, and version control, best practices for plotting of small data sets and reagent sharing platforms. This will help you to share your work with your future self, your immediate colleagues and the wider scientific community.
  • Thursday, March 18
  • 10:00 am - 12:00 pm
  • Research, Teaching, and Careers at Primarily Undergraduate Institutions (PUIs)
  • Session Chair:
  • Judy Leatherman, University of Northern Colorado
Organizers: J. Leatherman, T. Dohn, J. Merkle

This workshop focuses on equipping the faculty at PUIs with information to support undergraduate research, grant writing, integrating research and teaching, and supporting prospective PUI faculty in their career development. Our goals are: 1) Provide a forum in which those interested in a PUI career path can learn and interact with current PUI faculty, 2) Build community and connections between PUI faculty to provide support in issues specific to PUIs, 3) Share grant writing, mentoring, and teaching tips & techniques to encourage Drosophila research and integration in the classroom.
  • Friday, March 19
  • 1:00 pm - 2:00 pm
  • Multilingual Networking
  • Session Chair:
  • Jessica Velez, GSA

Join us for this exciting event to network in the language of your choice! At this multilingual networking event, Dros 21 participants who speak languages other than English have a chance to network and talk about science in their native language or language of choice with other participants. Advanced registration required.

  • Friday, March 19
  • 3:00 pm - 4:30 pm
  • Publishing Q & A
  • Session Chairs:
  • Ruth Isaacson, GSA
  • Tracey DePellegrin, GSA
  • Megan McCarty, GSA
Students and postdocs are invited to join journal editors—including editors and editorial staff from the GSA journals, GENETICS and G3: Genes|Genomes|Genetics—to discuss the ins and outs of getting an article published.

Brenda Andrews (G3: Genes|Genomes|Genetics)

Howard Lipshitz (GENETICS)

Michael Eisen (eLife)

Ondine Cleaver (Developmental Biology)

Swathi Arur (Development)

Mariana Wolfner (GENETICS, PLoS Biology, Fly)

Kelly Ross (Fly)

  • Tuesday, March 23
  • 11:00 am - 1:15 pm
  • Opening Keynote and Larry Sandler Award Talk
  • Session Chairs:
  • Nasser Rusan, National Institutes of Health
  • Amy Kiger, University of California, San Diego
  • Tuesday, March 23
  • 1:30 pm - 2:30 pm
  • FlyBase Workshop
  • Session Chair:
  • Susan Russo Gelbart, FlyBase

Pre-post questions you would FlyBase folks to answer here:  https://app.sli.do/event/qpvecq9s/live/questions

FlyBase invites all ADRC attendees to come to our virtual booth to learn how to make the best use of FlyBase tools and features for your research and teaching.   The 1-hour session will begin at 1:30pm with a 20-minute presentation "What’s New at FlyBase," followed by questions and answers.    

  • Tuesday, March 23
  • 2:30 pm - 4:30 pm
  • Cellular and tissue dynamics in development
  • Session Chairs:
  • Dorothy Lerit, Emory University School of Medicine
  • Steve Jean, Université de Sherbrooke
  • Kimberley Gauthier, University of Toronto
  • Tuesday, March 23
  • 2:30 pm - 4:30 pm
  • Gene Regulation and Epigenetics: From the MZT to Differentiation
  • Session Chairs:
  • Rhea Datta, Hamilton College
  • Amanda Amodeo, Dartmouth College
  • Jessica Sidisky, Lehigh University
  • Tuesday, March 23
  • 2:30 pm - 4:30 pm
  • Molecular adaptations and conflicts in Drosophila reproduction
  • Session Chairs:
  • Daniel Matute, University of North Carolina at Chapel Hill
  • Christopher Ellison, Rutgers
  • Ching-Ho Chang, The Fred Hutchinson Cancer Research Center
  • Tuesday, March 23
  • 2:30 pm - 4:30 pm
  • Mechanisms of tissue repair and homeostasis
  • Session Chairs:
  • Vicki Losick, Boston College
  • Mariano Loza-Coll, California State University, Northridge
  • Rodrigo Dutra Nunes, Johns Hopkins University
  • Wednesday, March 24
  • 11:00 am - 1:05 pm
  • Image Award/Plenary Session 1
  • Session Chairs:
  • Nasser Rusan, National Institutes of Health
  • Michelle Arbeitman, Florida State University
  • Wednesday, March 24
  • 1:30 pm - 2:30 pm
  • Networking Break 1
  • Session Chair:
  • Erin Suderman, GSA

Topics include:

Evolution, Immunity, and the Microbiome
Applying to Graduate School and Postdoc Positions
Cell Biology and Growth
Cell Stress and Cell Death
Chromatin, Epigenetics, and Genomics
Disability in Science
Diversity, Equity, and Inclusion
Junctions and Epithelial Dynamics
Doing Science at a PUI
LGBTQ+ in Science
Models of Human Disease

  • Wednesday, March 24
  • 2:30 pm - 4:30 pm
  • RNA Biology: Granules, Small RNAs, and Translational Regulation
  • Session Chairs:
  • Zhao (ZZ) Zhang, Duke School of Medicine
  • Vassie Ware, Lehigh University
  • Kasun Buddika, Indiana University Bloomington
  • Wednesday, March 24
  • 2:30 pm - 4:30 pm
  • New paradigms of organelle regulation and function
  • Session Chairs:
  • Daria Siekhaus, Institute of Science and Technology Austria
  • Jeremy Smyth, Uniformed Services University of the Health Sciences
  • Priya Dutta, Tata Institute of fundamental Research, Mumbai
  • George Aranjuez, University of Central Florida
  • Wednesday, March 24
  • 2:30 pm - 4:30 pm
  • Genome structure, function, and evolution
  • Session Chairs:
  • Laurie Stevison, Auburn Univeristy
  • Colin Meiklejohn, University of Nebraska
  • Brooke Peckenpaugh, Indiana University Bloomington
  • Wednesday, March 24
  • 2:30 pm - 4:30 pm
  • Regulatory and mechanical processes driving morphogenesis and pattern formation
  • Session Chairs:
  • Shaad Ahmad, Indiana State University
  • Ginger Hunter, Clarkson University
  • Alexis Stutzman, University of North Carolina at Chapel Hill
  • Haley Brown, Indiana University Bloomington
  • Wednesday, March 24
  • 5:00 pm - 6:30 pm
  • Education Platform Session
  • Session Chairs:
  • Justin DiAngelo, Penn State Berks
  • Hemlata Mistry, Widener University
  • Thursday, March 25
  • 11:00 am - 1:00 pm
  • Plenary Session 2 - Equity and Inclusion Plenary Session
  • Session Chairs:
  • Nadia Singh, University of Oregon
  • Michelle Arbeitman, Florida State University
  • Thursday, March 25
  • 1:15 pm - 2:15 pm
  • The effect of the COVID pandemic on the fly community
  • Session Chairs:
  • Mariana Wolfner, Cornell University
  • Tin Tin Su, University of Colorado
  • Tanya Hoodbhoy, National Institute of General Medical Sciences, NIH

The global pandemic is taking a toll on us all. In our profession, sustained productivity in terms of grants and publications is essential for continued competitiveness with funding and for successful job, promotion, and tenure applications. Yet, many recent studies show that the need to work remotely while fulfilling familial and other obligations during the pandemic is taking a toll on our productivity. Solving the pandemic problem is beyond our capabilities, but there are things each of us can do within our own sphere of influence. This event is to sit down and brainstorm to come up with such activities.

 

Schedule of Activities

  1. 2 min- Introduction by Tin Tin Su
  2. 25 min- Q&A with the panel, moderated by Tin Tin Su and Mariana Wolfner
  3. 25 min- free discussion in breakout rooms, brainstorm what we can do
  4. 8 min- Summing up by Mariana Wolfner

 

Panelists

Denise Montell, Duggan Professor and Distinguished Professor, University of California Santa Barbara

Tania Reis, Associate Professor, University of Colorado Anschutz Medical Campus

Jason Tennessen, Associate Professor, Indiana University 

Tanya Hoodbhoy, Program Director, National Institute of General Medical Sciences, NIH

 

Panel Questions

  1. Many states imposed restrictions, such as school closures, and asked non-essential workers to stay home. Can you tell us about your experience during these shutdowns?
  2. If your institute shut down, were you able to preserve reagents and stocks?
  3. What has been the biggest challenge thus far in running your research program? 
  4. Have you been able to get support from/provide support to researchers at your institute or in the community?
  5. Any advice for Drosophila biologists at a similar stage of their career?
  • Thursday, March 25
  • 1:30 pm - 2:30 pm
  • FlyBase Workshop
  • Session Chair:
  • Susan Russo Gelbart, FlyBase

Pre-post questions you would FlyBase folks to answer here:  https://app.sli.do/event/qpvecq9s/live/questions

FlyBase invites all ADRC attendees to come to our virtual booth to learn how to make the best use of FlyBase tools and features for your research and teaching.   The 1-hour session will begin at 1:30pm with a 20-minute presentation "What’s New at FlyBase," followed by questions and answers.    
  • Thursday, March 25
  • 2:30 pm - 4:30 pm
  • Neurodegeneration
  • Session Chairs:
  • John Tuthill, University of Washington
  • Brad Dickerson, University of North Carolina at Chapel Hill
  • Leire Abalde-Atristain, Oregon Health & Science University
  • Thursday, March 25
  • 2:30 pm - 4:30 pm
  • Life and death: Regulation of stress, cell cycle, cell growth, and cell death
  • Session Chairs:
  • Cathie Pfleger, Icahn School of Medicine at Mount Sinai
  • Erika Geisbrecht, Kansas State University
  • Junnan Fang, Emory University School of Medicine
  • Sudershana Nair, Albert Einstein College of Medicine
  • Thursday, March 25
  • 2:30 pm - 4:30 pm
  • Functional and computational genomics
  • Session Chairs:
  • Yasir Ahmed-Braimah, Syracuse University
  • Justin Crocker, EMBL
  • Li Zhao, Rockefeller University
  • Alex Majane, University of California, Davis
  • Thursday, March 25
  • 2:30 pm - 4:30 pm
  • Practicing innovative inclusion: tools to advance research excellence
  • Session Chairs:
  • Jennifer Alexander, Fox Chase Cancer Center
  • Andrew M Arsham, Bemidji State University
  • Thursday, March 25
  • 5:00 pm - 6:00 pm
  • Undergrad Platform Session
  • Session Chairs:
  • Afshan Ismat
  • Nicole Salazar
Talks
Ana Cecilia Luis Castañeda, Genotoxicity of water from the La Estanzuela dam in Mexico in the Drosophila wing spot test
Mellisa Xie, Mapping of high-throughput datasets reveals Max and E93 cluster at the histone locus
Michael Mysh, The basolateral polarity module promotes slit diaphragm formation in drosophila nephrocytes, a model of vertebrate podocytes
Aidan Dermady, The Drosophila voltage-gated ERG potassium channel seizure affects developmental time and oxidative stress resistance
Aliyah Penn, Bisphenol A differentially impacts neurodevelopment in Drosophila melanogaster from distinct genetic backgrounds

 

Poster Preview

Kaila Gemenes, Genome annotation of Drosophila ananassae dot chromosome contig 33
Kaitlyn Solberg, The role of the cell cycle regulator dacapo (dap) on embryonic PNS development
Amy Kwan, Differential expression of miR-210 in bees as an agent of maternal care
Corinne Croslyn, Temporal Clustering of Alcohol-Responsive genes in Drosophila
  • Friday, March 26
  • 11:00 am - 1:00 pm
  • Plenary Session 3
  • Session Chairs:
  • Guy Tanentzapf, University of British Columbia
  • Karen Hales, Davidson College
  • Friday, March 26
  • 1:30 pm - 2:30 pm
  • Networking Break 2
  • Session Chair:
  • Erin Suderman, GSA

Topics include:

Neural Circuits and Behavior
Neural Development and Physiology
Parents in Science
Patterning, Morphogenesis, and Organogenesis
Physiology, Metabolism, and Aging
Professional Development and Careers in Science
Regulation of Gene Expression
Reproduction and Gametogenesis
Signal Transduction
Stem Cells, Regeneration, and Tissue Injury
Teaching at a PUI

  • Friday, March 26
  • 2:30 pm - 4:30 pm
  • Metabolic control of diverse physiological processes from oocytes to hemocytes
  • Session Chairs:
  • Alissa Armstrong, University of South Carolina
  • Michelle Bland, The University of Virginia
  • Andrea Darby, Cornell University
  • Friday, March 26
  • 2:30 pm - 4:30 pm
  • Models of Human Disease I
  • Session Chairs:
  • Chiswili Chabu, University of Missouri, Columbia
  • Margaret Pearce, University of the Sciences
  • Aashika Sekar, University of Oxford
  • Friday, March 26
  • 2:30 pm - 4:30 pm
  • Germline Regulation and Behavior
  • Session Chairs:
  • Lindsay Lewellyn, Butler University
  • Josefa Steinhauer, Yeshiva University
  • Rafael Demarco, UCLA
  • Friday, March 26
  • 2:30 pm - 4:30 pm
  • Neurodevelopment
  • Session Chairs:
  • Robert Carrillo, University of Chicago
  • Divya Sitaraman, California State University
  • Sarah Ackerman, University of Oregon
  • Saturday, March 27
  • 11:00 am - 1:10 pm
  • Plenary Session 4
  • Session Chairs:
  • Amy Kiger, University of California, San Diego
  • Karen Hales, Davidson College
  • Saturday, March 27
  • 1:30 pm - 3:30 pm
  • Models of Human Disease II
  • Session Chairs:
  • Clement Chow, University of Utah
  • Erdem Bangi, Florida State University
  • Tanzeen Yusuff, Penn State University
  • Saturday, March 27
  • 1:30 pm - 3:30 pm
  • Host-Microbiome Interactions and Immunity
  • Session Chairs:
  • Robert Unckless, University of Kansas
  • Moria Chambers, Bucknell University
  • Mark Hanson, Swiss Federal Institute of Technology Lausanne
  • Saturday, March 27
  • 1:30 pm - 3:30 pm
  • Neural Circuits and Behavior
  • Session Chairs:
  • Brad Dickerson, University of North Carolina at Chapel Hill
  • John Tuthill, University of Washington
  • Meet Zandawala, Brown University
  • Colleen Palmateer, Florida State University
  • Saturday, March 27
  • 1:30 pm - 3:30 pm
  • Regulation of organ physiology across scales from RNA splicing to cell-cell contacts
  • Session Chairs:
  • Michelle Bland, The University of Virginia
  • Eric Folker, Boston College
  • Lydia Grmai, Johns Hopkins University
  • Sunday, March 28
  • 12:00 am - 11:59 pm
  • #FruitFlyTogether - Share and connect with your Drosophila community

Join your colleagues from around the world as we celebrate our community. Although there is no official programming today, all are invited to “gather” together at hashtag #FruitFlyTogether to show the many faces of our world and meaningful ways that we connect to make the fly community. 

 

Today we want to remember those we’ve lost, celebrate our many accomplishments, give a shout of praise for our inspiring colleagues/mentors/trainees, show others who we are, post pictures of our pets and tell everyone what we are doing today. Do you have on a t-shirt from a past Drosophila Conference? What about a shot of you and your labmates? Are you doing something outside of the lab today? Post your pictures on social media and use #Dros21 and #FruitFlyTogether.

  • Monday, March 29
  • 11:00 am - 1:35 pm
  • Techniques and Technology 
  • Session Chairs:
  • Stephanie Mohr, Harvard Medical School
  • Karen Kasza, Columbia University
  • Pavel Tomancak, Max Planck Institute of Molecular Cell Biology and Genetics
  • Justin Bosch, Harvard Medical School
  • Monday, March 29
  • 1:30 pm - 2:30 pm
  • Mentored Fellowships in active learning for faculty and postdocs: the PALM Network
  • Session Chair:
  • Sue Wick, The Palm Network
Presenter: Sue Wick, University of MN-Twin Cities, PI of PALM Network

Learn how to advance your teaching skills through the Promoting Active Learning and Mentoring (PALM) Network.  We will examine why to use active learning, key features of PALM, examples of PALM Fellow projects, how to get matched with a mentor, and the fellowship application form.
  • Monday, March 29
  • 3:00 pm - 5:00 pm
  • Lysosomal degradation pathways in development and disease
  • Session Chairs:
  • Andreas Jenny, Albert Einstein College of Medicine
  • Tor-Erik Rusten, Oslo University Hospital
  • Gabor Juhasz, Eötvös Loránd University


While endocytosis and phagocytosis degrade transmembrane proteins and extracellular material, autophagy encapsulates and digests cytosolic cargo, including protein aggregates and organelles. All these pathways converge in the degradative lysosome which acts as a hub controlling cellular growth signaling, metabolism and immune functions. In this workshop, an overview of recent progress in lysosomal degradation pathways is given by an renowned scientist in the field followed by talks selected from interested applicants. They will show novel data, point to emerging directions and discuss pressing open questions with the goal to foster discussions and interactions among scientists at various stages of their careers. 
 

Program:

 

3:00pm Tom Neufeld (University of Minnesota, USA)

“Lysosomal pathways: inside & out.”

 

3:30 pm Hannah Haushild (Simons Lab; University of Heidelberg, Germany)

“The fly ortholog of the Dent’s disease gene CLCN5 is required for endolysosomal

cholesterol and fatty acid extraction.”

 

3:42 pm Rajan Thakur (O’Connor-Giles lab, Brown University, USA)

ER-lysosome interactions promote autophagy to regulate synaptic growth.”

 

3:54 pm Satya Surabhi (Jenny lab; Albert Einstein College of Medicine, USA)

Title: “Addressing the physiological role of endosomal microautophagy.”

 

4:06 pm Nilay Nandi (Krämer lab; UT Southwestern Medical Center, USA)

The PPM-type phosphatase Nil regulates a phospho-switch at Acinus-S437A that

controls autophagic responses to Cd2+ exposure and neurodegenerative stress.”

 

4:18 pm Marco Milan (IRB, Barcelona, Spain)

“Aneuploidy, protein quality control mechanisms and senescence.”

 

4:30 pm Breakout rooms: identification of pressing questions

 

4:45 pm Plenum discussion: summary of pressing questions

  • Monday, March 29
  • 3:00 pm - 5:00 pm
  • Experimental and Computational Approaches in Systems Developmental Biology
  • Session Chairs:
  • Gregory Reeves, Texas A&M University
  • Jeremiah Zartman, Notre Dame University


Development is complex, with many highly interacting, dynamic parts working together to determine the fate map of the organism. Therefore, a systems approach is required, which includes omic approaches, optogenetics, live tissue imaging, predictive mathematical models, and machine learning. In this workshop, we will discuss cutting edge advances in these experimental and computational approaches, from the standpoint of Drosophila development. An emphasis will be placed on integration of modeling and experiments: models to summarize, predict, and propose experiments; experimental work to test and constrain models. The ultimate goal is to provide transferable skills/knowledge to the community.
 

3:00 pm Greg Reeves, Texas A&M University, Opening Remarks on Systems Developmental Biology

3:10 pm Tomer Stern, Princeton University, Whole embryo single cell mapping of morphogenetic domains during Drosophila gastrulation 

3:35 pm Nilay Kumar, University of Notre Dame, Data-driven image analysis and computational modeling approaches of epithelial morphogenesis

4:00 pm David Umulis, Purdue University, A rigorous comparison of BMP-mediated patterning through imaging and simulation reveals distinct mechanisms of gradient formation in zebrafish and Drosophila embryos

4:25 pm Stefano De Renzis, EMBL Heidelberg, Insights from optogenetics: Desensitisation of Notch signalling through dynamic adaptation in the nucleus

4:50 pm Jeremiah Zartman, University of Notre Dame, Concluding Remarks on the Workshop

  • Monday, March 29
  • 3:00 pm - 4:30 pm
  • microPublication Biology and the Drosophila Community
  • Session Chairs:
  • Karen Yook, Caltech
  • Daniela Raciti, Caltech


microPublication Biology (microPublication.org) is about speed and brevity: fast, short, and easy to draft publications that are peer-reviewed and citable. Upon publication, research results are directly deposited in databases such as FlyBase. Accepted articles are published in our Open Access journal, microPublication Biology. microPublication opens opportunities for sharing data, and engages scientists into scholarly communication at earlier stages of their career. Come hear from our editors and other microPublished Drosophila researchers and reviewers about how easy the process is.
 

Brian Oliver, NIDDK, microPublication Fly Science Officer

Thom Kaufman, Indiana University, microPublication Fly Science Officer

Tim Schedl, Washington University School of Medicine, St Louis, microPublication Worm Science Officer

Steven Marygold, Cambridge University/FlyBase

Michael O’Connor, University of Minnesota

Jacob Kagey, University of Detroit Mercy

Laura Reed, University of Alabama

Kai Zinn, California Institute of Technology

Melissa Gilbert-Ross, Emory University

Joyce Stamm, University of Evansville

Kayla Bieser, Nevada State College

Jung-Wan Mok, Korean Advanced Institute of Science and Technology

  • Tuesday, March 30
  • 3:00 pm - 6:00 pm
  • A community-based approach to understanding Drosophila Evolution through Space and Time (DEST)
  • Session Chairs:
  • Josefa González, IBE (CSIC-UPF)
  • Alan Bergland, University of Virginia
  • Martin Kapun, University of Zürich, Switzerland
This workshop will discuss ongoing efforts and recent advances from a community based effort to study the evolutionary dynamics and history of Drosophila melanogaster across its geographic range and sampled over seasonal, annual, and decadal time-scales. The primary goals of this workshop are to (1) highlight the development of this effort and work to grow this community based sampling and analysis effort, (2) discuss recent advances in our understanding of Drosophila evolution that utilize consortium-based efforts, and (3) enable access to existing genomic resources through hands-on training. 

Session 1. Presentations (10 minutes + 2 min questions each)

3:00 pm Thomas Flatt (Univ. of Fribourg), Josefa González (Institute of Evolutionary Biology, CSIC-UPF), & Paul Schmidt (Univ. of Pennsylvania): The DrosEU and DrosRTEC consortia: an overview

3:12 pm Alan Bergland (Univ. of Virginia) & Martin Kapun (Univ. of Zurich): The DEST dataset: preliminary insights from sequencing >13,000 flies collected around the world

3:24pm Esra Durmaz (Univ. of Fribourg): The DrosEU phenotyping collaboration

3:36pm Josefa González (Institute of Evolutionary Biology, CSIC-UPF): aDaptNATION: a citizen science network in adaptation genomics

3:48pm Daniel Matute (Univ. of North Carolina, Chapel Hill): The dynamics of admixture in African populations of D. melanogaster.

4:00pm Bernard Kim (Stanford University): An open comparative genomic resource of 101 highly contiguous drosophilid genomes

4:12pm Mara Lawniczak (Wellcome Sanger Trust):  Malaria transmitting mosquitoes over space and time

4:24pm Megan Wallace (University of Edinburgh): The prevalence and diversity of DNA viruses associated with Drosophila melanogaster in Europe

4:36 Break 

 

Session 2. Forum discussion.

4:50  Future consortia efforts. Discussion led by Thomas Flatt, Josefa González, Martin Kapun, Alan Bergland, Paul Schmidt, and Dmitri Petrov. 

5:20 Break

 

Session 3. Data workshop

5:30 Data workshop. Answer questions and follow up discussion about data accessibility, browser usage, etc., led by Martin Kapun, Alan Bergland, Jesús Murga, and Marta Coronado-Zamora.


 

  • Tuesday, March 30
  • 3:00 pm - 5:00 pm
  • Innate immunity at the crossroads of development, aging and chronic non-infectious diseases
  • Session Chairs:
  • Stanislava Chtarbanova, University of Alabama
  • Patricia Jumbo, Samford University of Alabama
  • Grace Boekhoff-Falk, University of Wisconsin-Madison

Introduction

3:00 pm Stanislava Chtarbanova, University of Alabama

Opening talk

3:05 pm Petros Ligoxygakis, Oxford University, Immunity in the fly brain is a key lifespan determinant.

Talks

3:30 pm Heather Broihier, Case Western Reserve University, Toll signaling shapes neuron-glia

interactions across lifespan.

3:45 pm David Wassarman, University of Wisconsin-Madison, The innate immune response affects

survival following traumatic brain injury in Drosophila.

4:00 pm Kim McCall, Boston University, Phagocyte-mediated cell death in the Drosophila ovary.

4:15 pm Jason Karpac, Texas A&M University, Exploring the Integration of Nutrient Sensing and Innate

Immune Signaling.

Panel discussion

4:30 pm Neal Silverman, University of Massachusetts Medical School

Petros Ligoxygakis, Oxford University

Stanislava Chtarbanova, University of Alabama

Patricia Jumbo-Lucioni, Samford University

Grace Boekhoff-Falk, University of Wisconsin-Madison

Breakout rooms

4:50 pm
  • Wednesday, March 31
  • 3:00 pm - 5:00 pm
  • Single-cell research in Drosophila: The Fly Cell Atlas and beyond
  • Session Chairs:
  • Lucy O'Brien, Stanford University
  • Hongjie Li, Baylor School of Medicine
  • Norbert Perrimon, Harvard Medical School
  • Brian Oliver, NIH/NIDDK

3:00-3:10: Liqun Luo, HHMI and Department of Biology, Stanford University, Overview of the Fly Cell Atlas: vision, platform, and resources.
3:10-3:20: Vincent Gardeux, EPFL School of Life Sciences (Switzerland), Analyzing, annotating and interpreting Fly Cell Atlas datasets using the Automated Single Cell Analysis Platform: ASAP.
3:20-3:30: Zita Carvalho-Santos, Champalimaud Centre for the Unknown, Lisbon Portugal, Mapping Metabolic Programs in a Whole Animal at Single Cell Resolution.
3:30-3:40: Cameron Berry, Department of Developmental Biology, Stanford University, Differential expression analysis by ASAP of single nuclear sequencing data uncovers novel genes required in testis cyst cells for germ line differentiation.
3:40-3:50: Yifang Liu, Harvard Medical School, Data mining and data analysis of Drosophila scRNA-seq datasets at DRSC.
3:50-3:54: One-minute flash talks:
Julian Dow, University of Glasgow, Single-cell physiology of the Malpighian tubule. 
Jessica Velten, Centre for organismal studies Heidelberg (COS), The molecular logic of synaptic wiring. 
Nikos Konstantinides, Institut Jacques Monod, Paris, France, A comprehensive series of temporal transcriptions factors in the developing fly visual system.
Ana Veloso, The Berlin Institute for Medical Systems Biology (BIMSB) at Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Neurogenic Lineage Decisions with Single Cell Resolution.
3:54-4:00 BREAK   
4:00-4:10: Katja Rust, Philipps University Marburg, Germany, An atlas and signaling map of the adult Drosophila ovary.
4:10-4:20: Helen Tauc, Genentech Inc., Investigating changes in transcriptional states of aging Drosophila intestinal stem cell populations.
4:20-4:30: Sara Aibar, VIB-KU Leuven, Tracking chromatin accessibility and enhancer activity at single-cell resolution throughout Drosophila brain development.
4:30-4:40: M. Neset Ozel, New York University, Terminal selector genes link neuronal fate with wiring specificity in the visual system.
4:40-4:50: Anna Alessandra Monaco, BIMSB-MDC, Humboldt Universität zu Berlin, cis-regulatory evolution in Drosophila developmental patterning.
4:50-4:53 One-minute flash talks: 
Swann Floc'hlay, Laboratory of Computational Biology, Department of Human Genetics, KU Leuven, Leuven, Belgium, Single-cell regulatory genomics of the wound response program.
Stefano Secchia, European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany, Putting some muscle into the dissection of single cell regulatory landscapes during embryogenesis.
Georg Vogler, Sanford Burnham Prebys Medical Discovery Institute, The Drosophila heart at single cell resolution.
4:53-5:00: Workshop wrap-up / post-workshop social at Gather.town (details provided at the workshop)                                

  • Wednesday, March 31
  • 3:00 pm - 5:00 pm
  • Dissecting interorganelle communication networks that fuel cellular and systemic signaling
  • Session Chairs:
  • Francesca Di Cara, Dalhousie University
  • Margret Bülow, University of Bonn
  • Andrew Simmonds


Organelles need to interact through vesicles transport, signaling molecules, and membrane contact sites to maintain their biological functions. Impairment of an organelle’s metabolic cascades may cause change in metabolic signaling that might lead to disease such as cancer or neurodegeneration. The specific mechanisms of how organelles communicate through signaling molecules and metabolites, how one organelle dysfunction affects another and the specific consequences in modifying defined interaction in health and disease are still missing and hard to untangle. Studies in Drosophila started to deconstruct complex signaling networks derived from organelle interactions that impact on aging, immunity, growth and stem cell behavior.
 

3:00 pm Mike Henne, UT Southwestern Medical Center Dallas TX  US, Using Drosophila to study organelle crosstalk & the functional diversity of lipid droplets 

 

3:15 pm Raghu Padinjat, National Centre for Biological Sciences-TIFR  GKVK Campus, Bangalore India, Localizing biochemical activities to ER-PM contact sites

 

3:30 pm Patrik Verstreken, VIB Center for Brain & Disease Research KU Leuven Belgium, Sleep dysfunction in Parkinson’s disease

 

3:45 pm Tao Wang, National Institute of Biological Sciences Beijing China, Mitochondria-ER Lipid Exchange Rebalances PE Homeostasis and maintains neuronal function

 

4:00 pm Victoria Hewitt, Whitworth Lab, MRC Mitochondrial Biology Unit, University of Cambridge UK, Decreasing pdzd8-mediated mitochondrial-ER contacts in neurons improves fitness by increasing mitophagy

 

4:15 pm Margret Bülow, University of Bonn, The ER protein Creld controls mitochondrial dynamics and dopaminergic neuron activity

 

4:30 pm Kai Sun, Center for Metabolic and Degenerative Diseases Institute of Molecular Medicine University of Texas Houston TX US, Regulation of Dynamics of ER-Lipid Droplets by A Novel Factor in Living Cells

 

4:45 pm Zulfeqhar Syed, Ten Hagen lab, NIH NIDCR Bethesda MD US, Tango1 coordinates ER/Golgi docking sites to mediate the proper packaging of mucin cargo

 

  • Wednesday, March 31
  • 3:00 pm - 5:00 pm
  • Community Engagement in Research: An Authentic Science Experience in Labs@Home 
  • Session Chairs:
  • Dara Ruiz-Whalen, eCLOSE Institute/Temple University- CEHS
  • Alana O'Reilly, Fox Chase Cancer Center/eCLOSE Institute
  • Amanda J Browne, PPD- Complementary worker of GSK
  • Nicole Harrington, University of Pennsylvania
  • Christopher Aichele, The Academy at Palumbo High School- School District of Philadelphia
  • Ebon Dyson, Abraham Lincoln High School- School District of Philadelphia


eCLOSE will present a hands-on activity (FlyBox) for researchers, interested in collaborating with schools in their communities. The model discussed not only empowers students to seek out further research opportunities but harnesses the power of citizen science (scientists collaborating with their community) to collect large, preliminary data sets.  This workshop will engage researchers and highlight ways to bring the lab into the home with safe, reproducible techniques perfect for collecting early data. Participants will discuss the implications of diet on disease (cancer) within a variety of cultures and overlay this on Drosophila developmental stages to empower more voices in research.

3:00 pm:  Dara Ruiz-Whalen, eCLOSE Institute/Temple University, Community engagement in research: An authentic science experience in Labs@Home.

3:10 pm: Amanda J. Browne*,  PPD- Complementary worker of GSK, The importance of role models for student engagement in research.

3:20 pm: Nicole Harrington*, University of Pennsylvania, From student to instructor: The school to science pipeline.

3:30 pm: Christopher Aichele, The Academy at Palumbo High School- School District of Philadelphia, Teaching AP Biology in an underfunded urban setting: Engagement with real data and analysis through eCLOSE Institute's classroom project. 

3:40 pm: Ebony Dyson, Abraham Lincoln High School- School District of Philadelphia, A culturally relevant science approach for students and their families.

*Both Amanda and Nicole are awardees of the 2021 Presidential Membership

3:50 pm: Hands on Activity

5 Breakout rooms with 10 participants each. Facilitated by the speakers of this workshop.  

 

4:45 pm: Closing- Dara Ruiz-Whalen

  • Thursday, April 01
  • 3:00 pm - 5:00 pm
  • Everything you ever wanted to know about sex  
  • Session Chairs:
  • Artyom Kopp, University of California, Davis
  • Rita Graze, Auburn University
  • Michelle Arbeitman, Florida State University

The workshop will cover the molecular genetics, development, neurobiology, genomics, evolution, and population genetics of sexual dimorphism, with an emphasis on cross-disciplinary interactions.  Presentations by invited speakers and selected abstracts from each discipline will be followed by moderated discussions.  The speakers are encouraged to summarize the key ideas behind their research for people working in other fields, outline the main unsolved questions, offer their opinions about future directions, and suggest connections that could be built with other disciplines.

3:00 PM Opening Remarks

3:05 PM – Stephen F. Goodwin, University of Oxford, A sex-specific switch between visual and olfactory inputs underlies adaptive sex differences in behavior

3:22 PM – Bryson Deanhardt, Duke University, Chromatin based regulation of fru and dsx in courtship circuits with social experience.

3:25 PM – Paula R Roy, University of Utah, It takes two: the behavioral and genetic basis of sexual signal coevolution.

3:35 PM – Lydia Grmai, Johns Hopkins University, Sex-specific ecdysone signaling is established by Dsx to control sexual differentiation in Drosophila gonads.

3:52 PM – Sharvani Mahadevaraju, NIDDK, Sexually dimorphic gonad development and sex-biased expression depends on karyotype (XX or XY), tra (presence or absence) and their interaction.

3:55 PM – Mukulika Ray, Brown University, A sex-specific role for the Drosophila Clamp protein in splicing during early embryonic development.

3:58 PM – Nitin Phadnis, University of Utah, Genomic conflicts and selfish sex chromosomes in Drosophila.

4:15 PM – Samuel Khodursky, The Rockefeller University, Evolution of sex-biased gene expression in the Drosophila brain.

4:18 PM – Peiwei Chen, California Institute of Technology, Adaptation of Drosophila piRNA program to sexually dimorphic TE landscape.

4:28 PM – Ian Dworkin, McMaster University, Sex differences in size and shape, do they reflect the same biological processes? Insights from 350 generations of artificial selection on size, and on sexual size dimorphism in Drosophila melanogaster.

4:45 PM – Caitlin E. McDonough-Goldstein, Syracuse University, Drosophila female reproductive glands contribute to mating plug composition and the timing of sperm ejection.

4:55 PM Q and A

  • Thursday, April 01
  • 3:00 pm - 5:00 pm
  • Developmental Mechanics
  • Session Chairs:
  • Rodrigo Fernandez-Gonzalez, University of Toronto
  • Guy Tanentzapf, University of British Columbia
  • Adam Martin, Massachusetts Institute of Technology


Developmental biology has undergone a revolution over the last two decades, largely as a result of work in Drosophila, that placed biomechanical, quantitative imaging, and mathematical modeling approaches at the forefront of the study of tissue morphogenesis. In particular, the establishment of tools to measure and manipulate mechanical forces in living organisms has demonstrated that mechanical forces profoundly shape animal development. In this workshop, we will review the most recent technical advances to visualize and quantify force generation in Drosophila, and we will discuss the latest results demonstrating the interplay between physical forces, molecular dynamics and tissue morphogenesis.

Speakers/Agenda

3:00 pm Anna Franz, University College London, Fat cells on the move: motile adipocytes in wound healing.

3:20 pm Bing He, Dartmouth University, A buckling-like mechanism enabled by ectodermal compression facilitates mesoderm invagination in Drosophila.

3:40 pm Kyra Campbell, University of Sheffield, The mechanics of making a midgut.

4:00 pm Jerôme Solon, Basque Foundation for Science, On the control of tissue mechanics during morphogenesis: how to seal epithelial gaps.

4:20 pm Natalie Dye, TU Dresden, Self-organized patterning of cell morphology in the Drosophila wing.

4:40 pm Yanlan Mao, University College London, Coping with mechanical stress – tissue dynamics during development and repair.

  • Thursday, April 01
  • 3:00 pm - 5:00 pm
  • Trends, issues and challenges in scientific publication
  • Session Chairs:
  • Howy Jacobs, Tampere University
  • Kelly Ross, San Diego State

Howard Lipshitz (Toronto), Editor in Chief, Genetics

Bernd Pulverer (Heidelberg), Director of Publications, EMBO Press

Kelly Ross (SDSU), Executive Editor, Epigenetics and Commissioning Editor, Fly

Steven Marygold (Cambridge), Group Manager, Flybase