Wednesday, April 06
7:00 pm - 9:00 pm
Town and Country Ballroom A
Opening General Session
Session Chairs:
Erika Bach, New York University School of Medicine
Ellie Heckscher, The University of Chicago
1 7:00 pm Welcome to #DROS22. Erika Bach, NYU School of Medicine, New York, NY
2 7:08 pm Drosophila Community Update. Tin Tin Su, University of Colorado, Boulder
3 7:13 pm GSA Welcome. Denise Montell, Genetics Society of America
4 7:23 pm Larry Sandler Award. Alissa Armstrong, University of South Carolina, Columbia, SC
5 7:27 pm Larry Sandler Award Talk - Sex-specific regulation of fat metabolism in Drosophila . Lianna Wat, The University of British Columbia
6 7:57 pm Keynote Introduction. Ellie Heckscher, University of Chicago
7 8:00 pm Central Nervous System Development: Stem Cells to Circuits. Chris Doe, University of Oregon
Thursday, April 07
8:30 am - 10:30 am
Town and Country Ballroom A
Plenary Session I
Session Chairs:
Sally Horne-Badovinac, The University of Chicago
Artyom Kopp, University of California, Davis
Justin DiAngelo, Penn State Berks
8 8:30 am Image Award . Dan Bergstralh, University of Rochester
9 8:35 am Origins of adult organ plasticity: How cell lifecycles define tissue states. Lucy O'Brien, Stanford University
10 9:05 am Regulating host phospholipid metabolism to fight infection. Michelle Bland, University of Virginia
11 9:35 am The genetics basis of inviability in hybrids between Drosophila melanogaster and D. santomea. Daniel Matute, University of North Carolina
12 10:05 am Tissue Biology of Chromosomal Instability. Marco Milan, IRB Barcelona
Thursday, April 07
11:00 am - 12:30 pm
Town and Country Ballroom A
Plenary Session II (Equity and Inclusion)
Session Chairs:
Andrew M Arsham, Bemidji State University
Rachel Smith-Bolton, University of Illinois Urbana-Champaign
13 11:00 am Collective Action for Institutional Transformation. Shaila Kotadia, Stanford University
14 11:30 am Strategies at UCSF for addressing barriers in science that disproportionately affect people from marginalized groups. Todd Nystul, UC San Francisco
15 12:00 pm NINDS Strategies for Enhancing the Diversity of Neuroscience Researchers. Marguerite Matthews, National Institute of Neurological Disorders
Thursday, April 07
4:30 pm - 6:30 pm
Town and Country Ballroom A
Neurodevelopment I
Session Chairs:
Vanessa Auld, University of British Columbia
Xin Li, University of Illinois
Yu-Chieh David Chen, New York University
16 4:30 pm A conserved anoctamin regulates olfactory neuron firing in Drosophila. Pratyajit Mohapatra, University of Connecticut
17 4:45 pm Dissection of the BMP-activated synaptic gene network identifies dichotomous BMP-responsive elements regulating synaptic functions. Robin Vuilleumier, University of British Columbia
18 5:00 pm γ-secretase promotes postsynaptic development through the cleavage of a Wnt receptor. Timothy Mosca, Thomas Jefferson University
19 5:15 pm Copia, a Drosophila retrotransposable element, regulates structural synaptic plasticity at the larval neuromuscular junction. Peter M'Angale, University of Massachusetts Chan Medical School
20 5:30 pm Chromatin regulatory networks underlying coordinated synaptic gene expression. James Kentro, Brown University
21 5:45 pm Fatty acid flux through triacylglycerol regulates neuroblast proliferation during oxidative stress. Eva Islimye, The Francis Crick Institute
22 6:00 pm Neuronal activity induces Glucosylceramide that is extruded via exosomes upon glial BMP signals for lysosomal degradation in glia. Liping Wang, Baylor College of Medicine
23 6:15 pm Sequential addition of neuronal temporal cohorts generates a stimulus on-set detection circuit. Zarion Marshall, University of Chicago
Thursday, April 07
4:30 pm - 6:30 pm
Town and Country Ballroom B
Evolution I
Session Chairs:
Ana Llopart, University of Iowa
Geoffrey Findlay , College of the Holy Cross
Cécile Courret, University of Rochester
Llewellyn Green, University of Houston
24 4:30 pm Partial overlap between inversions and genomic islands of divergence during early stages of ecological speciation in Drosophila yakuba. Erina A. Ferreira, CNRS
25 4:45 pm Chromatin Architecture Constrains Where Inversion Breakpoints Occur Over a Short-Time Scale in D. pseudoobscura. Dynisty Wright, The Pennsylvania State University
26 5:00 pm Cis-regulatory Changes at the Fatty Acid Elongase eloF Underlie the Evolution of Sex-specific Pheromone Profiles in Drosophila Prolongata. Yige Luo, University of California, Davis
27 5:15 pm Dissecting the genetic changes underlying the adaptation of the carbon dioxide receptor in the D. suzukii species complex. Alice Gadau, The Rockefeller University
28 5:30 pm Faster-X: Evolution of Drosophila melanogaster and Drosophila simulans Sex-biased Expression and Associated Chromatin. Adalena Nanni, University of Florida
29 5:45 pm Phage-derived DNAses are novel innate immune cell effectors in animals. Kirsten Verster, University of California - Berkeley
30 6:00 pm Widespread introgression across a phylogeny of 155 Drosophila genomes. Anton Suvorov, UNC
31 6:15 pm An odorant binding protein is required for mating plug formation and male fertility in Drosophila. Nora Brown, Cornell University
Thursday, April 07
4:30 pm - 6:30 pm
Town and Country Ballroom C
Physiology, Aging, and Metabolism I
Session Chairs:
Ethan Greenblatt, University of British Columbia
Laura Musselman, Binghamton University
Juliet Girard, University of California, Los Angeles
32 4:30 pm A novel role for CRTC linking age-related cardiac dysfunction and fibrosis to metabolic syndrome. Cristiana Dondi, Sanford Burnham Prebys Medical Discovery Institute
33 4:45 pm glial GBA links neural lipid metabolism and proteostasis with sleep. John Vaughen, Stanford University
34 5:00 pm Macrophages-derived Pvf2 modulates developmental transition by ecdysone synthesis regulation. Sergio Juarez-Carreño, Memorial Sloan Kettering Cancer Center
35 5:15 pm The Drosophila enzyme L-2-hydroxyglutarate dehydrogenase is required in the renal system for recovery from hypoxic stress. Nader Mahmoudzadeh, Indiana University
36 5:30 pm Differential regulation of glycogen homeostasis by TGFβ/Activin ligands. Heidi Bretscher, University of Minnesota- Twin Cities
37 5:45 pm Spenito, m6A RNA modification and the establishment of metabolic sexual dimorphism in larvae. Arely V. Diaz, University of Colorado, Anschutz Medical Campus
38 6:00 pm Acetyl-CoA mediated autoacetylation of fatty acid synthase as a metabolic switch for de novo lipogenesis in developing Drosophila. Ting Miao, Iowa State university
39 6:15 pm Mechanical activation of mitochondrial energy metabolism during cell differentiation. Zong-Heng Wang, National Heart, Lung, and Blood Institute, NIH
Friday, April 08
8:30 am - 10:00 am
Town and Country Ballroom A
Cell Biology I
Session Chairs:
Claire Thomas, Penn State
Blake Riggs, San Francisco State University
Marco Monroy, San Francisco State University
48 8:30 am The septate junction protein Bark beetle (Bark) is required for Drosophila intestinal barrier function and homeostasis. Rachel Hodge, UCLA
49 8:45 am Role of Intramembrane Spastic Paraplegia Proteins in Organization of Axonal ER and ER-mitochondria Contacts in Drosophila. ZEYNEP OZTURK, University of Cambridge
50 9:00 am The Abelson tyrosine kinase cooperates with the Nedd4-family ubiquitin ligase Suppressor of Deltex to regulate the late endosomal passage of Notch and modulate signaling activation. Julio Miranda-Alban, University of Chicago
51 9:15 am Understanding the Role of Loner in Myoblast Fusion. Amrita Shrikant Gokhale, UT Southwestern Medical Center
52 9:30 am Pericentrin-Like-Protein is a Kinesin-1 Adaptor that drives Centriole Motility. Matthew Hannaford, National Heart Lung and Blood institute
53 9:45 am Uncovering the mechanism of BNIP3-mediated mtDNA selection in the female germline. Anastasia Minenkova, University of Toronto
Friday, April 08
8:30 am - 10:00 am
Town and Country Ballroom B
Physiology, Aging, and Metabolism II
Session Chairs:
Ethan Greenblatt, University of British Columbia
Laura Musselman, Binghamton University
Juliet Girard, University of California, Los Angeles
54 8:30 am Tissue-specific chromatin profiling reveals a key role for Clock-dependent transcription in regulation of Drosophila photoreceptor homeostasis. Juan Jauregui-Lozano, Purdue University
55 8:45 am Circadian autophagy drives longevity response to Intermittent Time-Restricted-Feeding (iTRF). Matthew Ulgherait, Columbia University Medical Center
56 9:00 am The Neuronal and Molecular Mechanisms by Which Death Perception Impacts Fly Behavior and Lifespan. Tuhin Chakraborty, University of Michigan, Ann Arbor
57 9:15 am Blocking cell fusion inhibits age-induced polyploidy and maintains epithelial organization in Drosophila. Ari Dehn, Boston College
58 9:30 am Mechanisms of Systemic and Cellular Growth Control by Cholesterol. Mette Lassen, University of Copenhagen
59 9:45 am Hypoxia-dependent Control of Larval Maturation. Michael Turingan, University of Calgary
Friday, April 08
8:30 am - 10:00 am
Town and Country Ballroom D
Cell Division and Cell Growth
Session Chairs:
Sarah Siegrist, University of Virginia
Wu-Min Deng, Tulane University
Gary Teeters, University of Virginia
60 8:30 am The role of Jagunal protein in the establishment of cortical polarity in Drosophila melanogaster neuroblast. Lelahiwat Legesse, San Francisco state university
61 8:45 am Exploring the role of dynein in transporting cen mRNA to the centrosome. Hala Zein-Sabatto, Emory University
62 9:00 am Elucidating the mechanism of coactivator Taiman/AIB1-driven cell competition and its relation to the Adenomatous Polyposis Coli (APC) tumor suppressor in Drosophila. Colby Schweibenz, Emory University
63 9:15 am Cell-surface proteomic profiling identifies key regulators in epithelial cell competition. Ke Li, University of California, San Francisco
64 9:30 am Hypoxia-dependent regulation of epithelial tissue growth and development. Abhishek Sharma, University of Calgary
65 9:45 am Late Endosomes act as carriers for delivery of Ceramide phosphoethanolamine (CPE) with unique acyl chain anchors to cleavage furrows during male meiosis cytokinesis. Govind Kunduri, National Cancer Institute
Friday, April 08
8:30 am - 10:00 am
Town and Country Ballroom C
Immunity and Microbiome
Session Chairs:
Nichole Broderick, Johns Hopkins University
Will Ludington, Carnegie Institution for Science
Jessamyn Perlmutter (Jessie), University of Kansas
66 8:30 am Immunostimulatory Lipids in Drosophila Bacterial Infection. Sophia Parks, University of California Riverside
67 8:45 am Interorgan transfer of intact micron-sized lipid droplets to macrophages during the Drosophila immune response. Ishneet Kaur, Cal State University Fullerton
68 9:00 am Paying the amino acid cost of the humoral immune response to bacterial infection. William H. Pearson, Imperial College London
69 9:15 am The cytoplasmic incompatibility factor proteins CifA and CifB are both nucleases in Drosophila melanogaster. Rupinder Kaur, Vanderbilt University
70 9:30 am A symbiotic niche in the Drosophila gut regulates the stable association of a multispecies community. Ren Dodge, Carnegie Institute of Washington
71 9:45 am The Turandot proteins promote tolerance to stress by regulating energy consumption and tracheogenesis. Alexia L. Carboni, EPFL
Friday, April 08
10:30 am - 12:30 pm
Town and Country Ballroom A
Cell Biology II
Session Chairs:
Claire Thomas, Penn State
Blake Riggs, San Francisco State University
Marco Monroy, San Francisco State University
72 10:30 am Regulation of Misshapen during Border Cell Migration. Gabriela Molinari Roberto, Université de Montréal
73 10:45 am Investigating mechanisms regulating actin assembly in the early Drosophila embryo. Anna Yeh, MIT
74 11:00 am Discovery of a novel competitive interaction between the Chlamydia trachomatis early effector Tarp and the endogenous actin bundler Singed/Fascin during mechanosensory bristle development. George Aranjuez, University of Central Florida
75 11:15 am Sufficiency of active Rac to drive whole tissue phagocytosis in vivo. Abhinava Mishra, University of California Santa Barbara
76 11:30 am WAVE regulatory complex facilitates cell rearrangements through the generation of an F-Actin subpopulation at tri-cellular junction in the follicular epithelium. Lisa Calvary, iGReD, FACULTE DE MEDECINE ET PHARMACIE
77 11:45 am Fat2 polarizes the WAVE complex to align protrusions for collective cell migration. Audrey Williams, University of Chicago
78 12:00 pm Defining the role of prostaglandins in collective cell migration. Samuel Mellentine, University of Iowa
79 12:15 pm Microtubule acetylation promotes epithelial cell stretching and squamous cell carcinogenesis in Drosophila. Rachita Bhattacharya, Indian Institute of Technology Kanpur, India
Friday, April 08
10:30 am - 12:30 pm
Town and Country Ballroom B
Gene Regulation
Session Chairs:
Steven DeLuca, Brandeis University
Trisha Wittkopp, University of Michigan
Colleen Hannon, University of California, Berkeley
80 10:30 am Maternal pioneer factor CLAMP regulates sex-specific transcript diversity in early Drosophila embryos. Mukulika Ray, Brown University
81 10:45 am Hippo pathway transcriptional regulators alter chromatin binding dynamics of the transcription factor Scalloped. Samuel Manning, Monash University
82 11:00 am Hox linker domain phosphorylation alters Exd-Hox DNA-binding preferences and regulates gene expression. William Glassford, Columbia University
83 11:15 am Assembly of the Brain tumor RNA decay pre-complex expedites downregulation of Notch signaling following asymmetric stem cell division. Hideyuki Komori, University of Michigan
84 11:30 am Using CRISPRi to uncover mechanisms of transcriptional repression by Rb and CtBP co-repressors. Ana-Maria Raicu, Michigan State University
85 11:45 am Sculpture of a sex-specific piRNA program. Peiwei Chen, California Institute of Technology
86 12:00 pm The steroid hormone Ecdysone coordinates larval growth and development through its interaction with the transcriptional repressor Smrter. Joanna Wardwell-Ozgo, Emory University School of Medicine
87 12:15 pm Embryo development requires histone acetylation by Nejire during the maternal-to-zygotic transition. Audrey Marsh, University of Wisconsin-Madison
Friday, April 08
10:30 am - 12:30 pm
Town and Country Ballroom C
Neurobehavior I
Session Chairs:
Karla Kaun, Brown Univeristy
Marie Suver, Vanderbilt University
John Hernandez, Brown Univeristy
88 10:30 am A hymenopteran odorant alerts flies to bury eggs. Shaun Davis, University of Arizona
89 10:45 am A taste for toxins: Evolution of feeding preferences in the herbivorous drosophilid Scaptomyza flava. Julianne Pelaez, University of California, Berkeley
90 11:00 am The mRNA-binding protein Pumilio pleiotropically regulates food-related phenotypes through foraging. Ina Anreiter, University of Toronto
91 11:15 am Genetic Variation in Cocaine Preference in the Drosophila melanogaster Genetic Reference Panel. Jeffrey Hatfield, Clemson University
92 11:30 am Descending neurons coordinate anterior grooming behavior in Drosophila. LI GUO, University of California, Santa Barbara
93 11:45 am Drosophila females receive male substrate-borne signals through specific leg neurons during courtship. Caroline Fabre, University of Cambridge
94 12:00 pm Color augments motion vision for detecting approaching objects in Drosophila. Kit D Longden, HHMI Janelia Research Campus
95 12:15 pm STIM dependent dopamine-neuropeptide axis maintains the larval drive to feed and grow. Nandashree Kasturacharya, National Centre for Biological Science
Friday, April 08
10:30 am - 12:30 pm
Town and Country Ballroom D
Stem Cells, Regeneration, and Tissue Repair
Session Chairs:
Lesley Weaver, Indiana University
Adrian Halme, University of Virginia School of Medicine
Mahi Rahman, University of Utah - Huntsman Cancer Institute
96 10:30 am chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche. CHEN YUAN TSENG, NYU Grossman School of Medicine
97 10:45 am Role for local ecdysone signaling in Drosophila imaginal wing disc regeneration. Douglas Terry, Emory University
98 11:00 am Blocking the native differentiation program recapitulated in yki3S/A-induced midgut tumor alters the tumor cells’ capacity to disseminate and induce cachexia-like wasting. Inez Pranoto, University of Washington
99 11:15 am Enterocyte dynamics in the Drosophila adult midgut epithelium upon infection. Shyama Nandakumar, Cornell University
100 11:30 am PAAC to the new normal: Intravital imaging of dynamic brush border repair in the adult Drosophila intestine. Anthony Galenza, Stanford University
101 11:45 am Asymmetric nucleosome density and differential condensation of sister chromatids coordinates with Cdc6 to ensure distinct cell fates. Rajesh Ranjan, Johns Hopkins University,
102 12:00 pm Rab35 mediates two distinct pathways that regulate actin modification through Mical/SelR and actin remodeling through Septins during cell wound repair. Mitsutoshi Nakamura, Fred Hutchinson Cancer Research Center
103 12:15 pm Re-entry into mitosis and regeneration of intestinal stem cells through enteroblast dedifferentiation in Drosophila midguts. Aiguo Tian, Tulane University
Friday, April 08
4:30 pm - 6:30 pm
Town and Country Ballroom A
Neurodevelopment II/Neurobehavior II
Session Chairs:
Marie Suver, Vanderbilt University
Karla Kuan, Brown University
Yu-Chieh David Chen, New York University
Vanessa Auld, University of British Columbia
Xin Li, University of Illinois
John Hernandez, Brown University
104 4:30 pm Cellular and molecular basis of detection of acidic pH in fly gustatory system. Anindya Ganguly, University of California, Santa Barbara
105 4:45 pm Developmental mechanisms regulating the formation and function of drosophila sleep-wake circuit. Mubarak H Syed, University of New Mexico
106 5:00 pm Associative learning drives longitudinally-graded presynaptic plasticity of neurotransmitter release along axonal compartments. Aaron Stahl, The Scripps Research Institute
107 5:15 pm A conserved RNA binding protein regulates RNAs critical for neurodevelopment. Carly Lancaster, Emory University
108 5:30 pm Recovery from cold-induced reproductive dormancy is regulated by temperature-dependent AstC signaling. Matthew R. Meiselman, Cornell University
109 5:45 pm Orion bridges phosphatidylserine and Draper in the phagocytosis of somatosensory neurons in Drosophila. Hui Ji, Cornell University
110 6:00 pm The Circular RNA Edis-Relish-Castor Axis Regulates Neurodevelopment. Wei Liu, Johns Hopkins University School of Medicine
111 6:15 pm Netrins and receptors control Drosophila optic lobe organization and transmedullary neuron axon targeting. Yu Zhang, University of Illinois Urbana-Champaign
Friday, April 08
4:30 pm - 6:30 pm
Town and Country Ballroom B
Evolution II
Session Chairs:
Geoffrey Findlay, College of the Holy Cross
Ana Llopart, University of Iowa
Cécile Courret, University of Rochester
Llewellyn Green, University of Houston
112 4:30 pm Functional divergence of the bag of marbles gene in the Drosophila melanogaster species group. Jaclyn Bubnell, Cornell University
113 4:45 pm Cross-species incompatibility between a DNA satellite and the Drosophila homolog of Spartan poisons germline genome integrity. Cara Brand, University of Pennsylvania
114 5:00 pm A putative de novo evolved gene is essential for male fertility via a paternal effect. Sara Guay, College of the Holy Cross
115 5:15 pm The Y-linked gene, WDY, is necessary for sperm storage in Drosophila melanogaster. Yassi Hafezi, Cornell University
116 5:30 pm Investigating the evolution of new body parts in the rapidly evolution genitalia of Drosophila. Gavin Rice, University of Pittsburgh
117 5:45 pm Do supergenes mediate seasonal adaptation in overwintering Drosophila? Joaquin Nunez, University of Virginia
118 6:00 pm The evolution and genetic mechanism of sex-ratio meiotic drive in Drosophila affinis. Wen-Juan Ma, University of Kansas
119 6:15 pm The genetic basis of cardiac glycoside resistance in wild-caught Drosophila melanogaster. Arya Rao, Columbia University
Friday, April 08
4:30 pm - 6:30 pm
Town and Country Ballroom C
Reproduction and Gametogenesis
Session Chairs:
Kari Lenhart, Drexel University
Jennifer Mierisch , Loyola University of Chicago
Rafael Demarco, University of California, San Francisco
120 4:30 pm Old Hormones, new tricks: Juvenile Hormones ensure primordial germ cells reach the embryonic somatic gonad. Lacy Barton, NYU, Skirball Institute
121 4:45 pm The role of Drosophila germ granules in regulating mRNA stability during germ cell development. Anna Hakes, Princeton University
122 5:00 pm A feedback loop between heterochromatin and the nucleopore complex controls germ-cell to oocyte transition during Drosophila oogenesis. Kahini Sarkar, University at Albany, SUNY
123 5:15 pm Single-cell testes expression of ampliconic meiotic drivers on the sex chromsomes of Drosophila miranda. Kevin Wei, University of California Berkeley
124 5:30 pm Ecdysone signaling times border cell migration by regulating protrusive activity and cell-cell adhesion. Mallika Bhattacharya, University of Maryland, Baltimore County
125 5:45 pm Transcriptome analysis implicates circadian clock genes in Sex Peptide-dependent post-mating responses in Drosophila melanogaster females. Sofie Delbare, Cornell University
126 6:00 pm Cell intruder targeting system mediates paternal mitochondrial destruction after fertilization in Drosophila. Sharon Ben-Hur, Weizmann institute of science
127 6:15 pm Genetic coordination of sperm morphology and seminal fluid proteins promotes male reproductive success in Drosophila melanogaster. Jake Galvin, George Washington University
Saturday, April 09
8:00 am - 10:00 am
Town and Country Ballroom C
Patterning and Morphogenesis I
Session Chairs:
Seyeon Chung, Louisiana State University
Todd Blankenship, University of Denver
Raj Loganathan, Johns Hopkins University School of Medicine
136 8:00 am Visceral organ morphogenesis via calcium-patterned muscle constrictions. Noah Mitchell, University of California-Santa Barbara
137 8:15 am Maintaining symmetry in morphogenetic movements. Celia Smits, Princeton University
138 8:30 am Malvolio, a Fork head target metal ion transporter, is required for salivary gland morphogenesis. Srihitha Akula, Johns Hopkins University
139 8:45 am Defining the structure and function of the multivalent protein network at cell-cell adherens junctions during morphogenesis. Anja Schmidt, University of North Carolina at Chapel Hill
140 9:00 am A feedback mechanism mediated by actomyosin activity-dependent apical targeting of Rab11 vesicles reinforces apical constriction. Wei Chen, Dartmouth College
141 9:15 am Mechanical cues planar polarize Pins and orient divisions during Drosophila gastrulation. Jaclyn Camuglia, MIT
142 9:30 am Tissue geometry reorients in-plane homeotic tension to promote folding. Floris Bosveld, INSTITUT CURIE
143 9:45 am The flipside of tissue growth: how the two layers of the wing imaginal disc keep pace with each other. Sophia Friesen, University of California, Berkeley
Saturday, April 09
8:00 am - 10:00 am
Town and Country Ballroom B
Chromatin
Session Chairs:
Julie Secombe, Albert Einstein College of Medicine
Amanda Amodeo, Dartmouth College
Dahong Chen, NIH
144 8:00 am Uncovering how the pioneer transcription factor Grainy head binds and opens chromatin. Meghan Freund, University of Wisconsin-Madison
145 8:15 am Image-based investigation of enhancer-promoter bridging in the Drosophila genome. Aleena Patel, Stanford University
146 8:30 am Drosophila genome architectural proteins form in vivo liquid -liquid phase separating. Bright Amankwaa, University of Tennessee, Knoxville
147 8:45 am Chromatin state transitions in the Drosophila intestinal lineage gives new insights into cell type specification. Manon Josserand, Institut Curie
148 9:00 am Condensin II loss ameliorates long-range chromosomal interactions in both active and inactive physical compartments within a chromosome territory. Randi Isenhart, University of Pennsylvania
149 9:15 am Histone gene replacement reveals functional independence, redundancy and synergism between lysine 36 of H3.2 and H3.3. Harmony Salzler, UNC Chapel Hill
150 9:30 am Single-cell chromatin accessibility in Drosophila melanogaster human tauopathy model. Eve Lowenstein, Oregon Health & Science University
151 9:45 am Simultaneous cellular and molecular phenotyping of embryonic mutants using single cell regulatory trajectories. Stefano Secchia, European Molecular Biology Laboratory (EMBL)
Saturday, April 09
8:00 am - 10:00 am
Town and Country Ballroom A
Models of Human Disease I - Diseases with a Neurological Focus
Session Chairs:
Tirtha Kamal Das , ICAHN School of Medicine at Mount Sinai
Daniela Zarnescu , University of Arizona
Rebekah Keating Godfrey , University of Arizona
152 8:00 am A KDM5-Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation. Hayden Hatch, Albert Einstein College of Medicine
153 8:15 am Neuronal mechanisms of neurofibromin dependent metabolic regulation. Valentina Botero, Scripps Research Institute
154 8:30 am Traip controls brain size via suppression of mitotic DNA bridges. Ryan O'Neill, National Heart, Lung, and Blood Institute, NIH
155 8:45 am Dietary restriction ameliorates TBI-induced phenotypes in Drosophila melanogaster. Rebecca Delventhal, Lake Forest College
156 9:00 am Cyclin-dependent kinase 8 regulates mitochondrial morphology and modulates a Parkinson’s disease model in Drosophila. Zhe Liao, Simon Fraser University
157 9:15 am Endurance exercise ameliorates phenotypes in Drosophila models of Spinocerebellar Ataxias. Alyson Sujkowski, Wayne State University
158 9:30 am Loss of function variants in TIAM1 are associated with developmental delay, intellectual disability and seizures. Shenzhao Lu, Baylor College of Medicine
159 9:45 am Extremely rare variants in EIF4A2 are associated with a neurodevelopmental disorder characterized by hypotonia, intellectual disability and epilepsy. Maimuna Paul, Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine
Saturday, April 09
10:30 am - 12:00 pm
Town and Country Ballroom C
Patterning and Morphogenesis II
Session Chairs:
Seyeon Chung, Louisiana State University
Todd Blankenship, University of Denver
Raj Loganathan, Johns Hopkins University School of Medicine
168 10:30 am Cactin, a component of spliceosome C complex, is required for collective border cell polarization and migration in the Drosophila ovary. Guangxia Miao, University of California-Santa Barbara
169 10:45 am The cytoskeletal mechanics that shape a stem cell niche. Bailey Warder, University of Pennsylvania
170 11:00 am Endocytic regulation of Fat protocadherins in tissue growth and morphogenesis. Jyoti Misra, University of Texas at Dallas
171 11:15 am Inter-organ signaling regulates the onset of myoblast fusion. Zhi-Rong Ruan, UT Southwestern Medical Center
172 11:30 am Distinct contributions of ECM proteins to basement membrane mechanical properties in Drosophila. Uwe Töpfer, Technische Universität Dresden
173 11:45 am Affinity-driven germline-soma interactions mediate Drosophila oogenesis. Vanessa Weichselberger, University of Freiburg
Saturday, April 09
10:30 am - 12:00 pm
Town and Country Ballroom A
Models of Human Disease II
Session Chairs:
Tirtha Kamal Das , ICAHN School of Medicine at Mount Sinai
Daniela Zarnescu , University of Arizona
Rebekah Keating Godfrey , University of Arizona
174 10:30 am Genetic modifiers of NGLY1 deficiency identified through a Drosophila genetic screen point to the role of NGLY1 in ERAD. Travis Tu'ifua, University of Utah
175 10:45 am Identifying the genetic links between insomnia and cardiovascular disease using Drosophila models of sleep and cardiac physiology. Farah Abou Daya, University of Alabama at Birmingham
176 11:00 am A multi-model system approach identifies genetic interactions underlying atrial fibrillation susceptibility. James Kezos, Sanford Burnham Prebys Medical Discovery Institute
177 11:15 am Exploring the effects of diet-induced obesity on the invasiveness of Drosophila tumours. Cecilia Cabrera, MRC London Institute of Medical Sciences
178 11:30 am The Clot Thickens: Tumor-induced coagulopathy is a conserved driver of host mortality. Katy Ong, UC Berkeley
179 11:45 am Modeling Paraneoplastic Diabetes in Drosophila. Jyoti Tripathi, Indian Institute of Technology Kanpur
Saturday, April 09
10:30 am - 12:00 pm
Town and Country Ballroom B
Cell Stress and Cell Death
Session Chairs:
Deepika Vasudevan, University of Pittsburgh
Andreas Jenny, Albert Einstein College of Medicine
Lydia Grmai, University of Pittsburgh
180 10:30 am Ionizing Radiation induces cells with past caspase activity that contribute to the adult organ in Drosophila and show reduced Loss of Heterozygosity. Sarah Colon Plaza, University of Colorado Boulder
181 10:45 am Irradiation-Induced Cell Migration: An Epithelial-Mesenchymal Transition Process Regulated By Low-Level Caspase Activity. Lena Sapozhnikov, The Weizmann Institute of Science
182 11:00 am A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress. Hans Dalton, University of Utah
183 11:15 am The Protein Phosphatase-1 regulatory subunit dPPP1R15 controls collective cell migration via the eIF2-alpha-ATF4-dependent ER stress pathway. Yujun Chen, Kansas State University
184 11:30 am Increased intracellular pH promotes cell death in the developing Drosophila eye. Joanne Mendez, San Jose State University
185 11:45 am Lamp1 mediates lipid transport, but is dispensable for autophagy in Drosophila. Norin Chaudhry, Iowa State University
Saturday, April 09
4:00 pm - 6:00 pm
Town and Country Ballroom A
Techniques and Technology Session
Session Chairs:
Benjamin White, NIH
Jonathan Zirin , Harvard Medical School
Oguz Kanca, Baylor College of Medicine
192 4:00 pm Enabling recombination on the 4th chromosome: FRT101F and Bloom syndrome helicase. Stuart Newfeld, Arizona State Univ
193 4:15 pm Temperature-Inducible precision guided Sterile Insect Technique, TI-pgSIT. Nikolay Kandul, UC San Diego
194 4:30 pm Seamless genetic engineering via CRISPR-triggered SSA allows spatio-temporal control of gene labelling. Gustavo Aguilar, University of Basel
195 4:45 pm SpyChIP identifies genome-wide and cell type-specific transcription factor occupancy. Siqian Feng, Columbia University
196 5:00 pm The continuum of Drosophila embryonic development at single cell resolution. Xingfan Huang, University of Washington
197 5:15 pm Optogenetic manipulation of endogenous proteins in Drosophila by light-inducible trapping. Yineng Xu, Cornell University
198 5:30 pm Spying on the dynamics of neuropeptides by the GRAB sensors in Drosophila. xiju xia, Peking University
199 5:45 pm Cryopreservation method for Drosophila melanogaster embryos. Li Zhan, University of Minnesota
Saturday, April 09
7:45 pm - 10:00 pm
Town and Country Ballroom A
Plenary Session III
Session Chairs:
Artyom Kopp, University of California, Davis
Erika Bach, New York University School of Medicine
200 7:45 pm GSA Awards. Denise Montell, Genetics Society of America
201 8:00 pm Minute mutations, cell competition, and cellular surveillance. Nick Baker, Albert Einstein College of Medicine
202 8:30 pm Innate immune signaling sculpts neuron-glia interactions across lifespan. Heather Broihier, Case Western Reserve University
203 9:00 pm Coping with mechanical stress: tissue dynamics in homeostasis and repair. Yanlan Mao, University College London
204 9:30 pm The evolution of morphological novelties at the cellular and gene regulatory levels. Mark Rebeiz, University of Pittsburgh
Need a little more space? This session will be broadcast in Town & Country B too
Sunday, April 10
8:30 am - 10:30 am
Town and Country Ballroom A
Closing Plenary
Session Chairs:
Ellie Heckscher, The University of Chicago
Justin DiAngelo, Penn State Berks
Sally Horne-Badovinac, The University of Chicago
205 8:30 am What long-term quantitative Imaging of stem-cells in their natural environment can tell us about the way they are born, differentiate, and talk to eachother. Guy Tanentzapf, University of British Columbia, Canada
206 9:00 am Becoming an oocyte: demise of the germ cell program and new beginnings. Prashanth Rangan, Icahn School of Medicine at Mount Sinai
207 9:30 am Pioneers, settlers, and life on the OregonR trail: Transcriptional regulation during development. Melissa Harrison, University of Wisconsin-Madison
208 10:00 am Temporally dynamic antagonism between transcription and chromatin compaction controls stochastic photoreceptor specification. Robert Johnston, JOHNS HOPKINS UNIVERSITY