PgmNr D153: A SANT-like domain-containing protein regulates lipid droplet size.

Authors:
X. Huang; Y. Yao; X. Li; Z. Liu


Institutes
IGDB, CAS, Beijing, Beijing, CN.


Keyword: metabolism

Abstract:

Lipid droplets are the main lipid storage sites in cells. The size of LDs varies greatly under different physiological conditions. Despite many studies reporting factors important for lipid storage, the underlying mechanisms of LD size regulation are still not fully understood. Through a large-scale overexpression screen in the Drosophila larval fat body, we found that a SANT-like domain-containing protein is critical for LDs size regulation. Overexpressing this protein leads to enlarged LDs, while mutations have small LDs. Proteins with SANT-like domain have been previously linked to chromatin remodeling. Here we provide multiple evidences suggest that this SANT-like domain-containing protein may links to NURF chromatin remodeling complex via interacting with PZG. Therefore, our work provides a new insight of lipid droplet size regulation.