Our understanding of gene regulation has grown to include the role of chromatin in managing where and when genes are expressed. Chromatin, the organizational framework that packages DNA into the nucleus, affects the access of specific regulatory proteins to DNA sequences. As part of the regulatory structure, chromatin is divided into domains. Specific sequences of DNA called insulators, which are bound by proteins called insulator binding proteins (IBPs), assist in establishing these domains. We are interested in how the Drosophila melanogaster IBP Boundary Element Associated Factor (BEAF) acts within the chromatin landscape to control gene expression. Previous data shows BEAF localizes to hundreds of promoter regions within the genome, often at housekeeping genes. This may indicate a role in promoter function, a non-traditional role for an IBP. We have evidence to suggest a positive interaction of BEAF with the Polybromo-associated Brahma (PBAP) chromatin remodeling complex, specifically the Polybromo subunit. We are probing the nature of this interaction using animal and cell culture experiments to determine the effect of this association on transcription. We have tested for genetic interactions using our rough eye screen and have dissected Polybromo to determine which domains specifically interact with BEAF. We have also used the high through-put techniques PRO-seq and MNase-seq after RNAi mediated knockdowns of BEAF and Polybromo in S2 cells. Progress in analyzing the relationship between BEAF and PBAP will be presented.