Correct orientation of cell polarity and division is important for the directional tissue growth and morphogenesis, but the mechanism underlying this process is remained unclear. Here, we identified multiple Wnt proteins act as directional cues to regulate the orientation of the cell polarity and division of Drosophila neural stem cells, leading to the correct orientation of the nervous tissue growth. Wnt proteins play essential roles in the efficient formation and orientation of the Par-complex polarity in the neural stem cells through Frizzled/beta-Catenin signaling, which in turn dictate the central-to-peripheral polarity of the nervous tissue. Our results unveil the novel function of the Wnt signaling in the regulation of the tissue morphogenesis.