The small GTPase Rab11, a major regulator of endomembrane traffiking, has been linked to developmental defects. Using loss and gain-of-function approaches in Drosophila, new roles for Rab11 in mediating the process of myoblast proliferation, migration and differentiation during Drosophila indirect flight muscle development have been identified. Rab11 function in the developing IFMs is a prerequisite for the differentiation and de-novo development. It functions in the proliferating adult muscle precursors (AMPs) for normal division and for maintaining cellular contact between the neighbouring myoblasts, failure to which results in pre matured differentiation of myoblast. Genetic interaction studies show that Rab11 partners with Notch in patterning the IFMs, since expression of ligand independent Notch in Rab11 mutant background can rescue the muscle defects and restores the myoblast number. Rab11 is also involved in the morphogenesis of Malpighian tubules which is one of the important organs for excretion and osmoregulation in insects and escapes histolysis during metamorphosis. It has two cell types, the principal cells (PCs) and stellate cells (SCs). Rab11 downregulation in PCs by using Gal4c-42 leads to shortening of MTs due to reduced endoreplication. Also interestingly, the SCs do not show mesenchymal to epithelial transition and do not differentiate into characteristic star shaped cells during pupal stages, show altered physiological functions and individuals die at pharate adult stage. In another set of experiments we found Rab11 playing an instrumental role in epithelial morphogenesis of developing Drosophila embryos. We observed that embryos lacking a functional Rab11, fail to undergo Dorsal Closure and show improper cuticle synthesis. The epithelial cells of these embryos, lack proper cell-adhesions and show anomalous expression patterns of activated JNK, which interestingly, are quite similar to the cells which lose their apical-basal polarity, suggesting a putative interaction of Rab11 functions with the JNK pathway. We suggest that Rab11 mediated regulation of inter-cellular membrane trafficking may be an additional mechanism to regulate the intercellular signaling during Drosophila development..