Systems of phosphate homeostasis are required for virulence of bacterial pathogens. In a transposon mutant screen for new elements of Candida albicans Target of Rapamycin (TOR) signaling, we found a homolog of the major phosphate plasma membrane transporter in S. cerevisiae, Pho84, to be required for normal TOR activity. The link between Pho84 and TOR signaling in C. albicans does not seem to consist in pH homeostatic mechanisms, but appears to go through the EGO complex component Gtr1. Mutants in PHO84 are hypersemsitive to cell wall stress and oxidative stress, and fail to eliminate reactive oxygen species. Their hyphal morphogenesis is misregulated, and they are defective in biofilm formation. They are unable to damage host cells in ex vivo models, and are killed more efficiently by neutrophils. In a wild type Drosophila model, they are nearly avirulent. The macronutrient phosphate is required for DNA replication, ribosome biogenesis, expansion of membranes and key metabolic processes like glycolysis and oxidative phosphorylation. We found its acquisition to be connected to critical functions in C. albicans pathogenesis.