An increasing number of researchers are utilizing the powerful genetic and molecular tools offered by Drosophila to develop and study fly lines which faithfully recapitulate aspects of human disease or human health-related processes. Drosophila models are being used in all aspects of human disease research, including basic research into the underlying mechanisms of disease, screens for disease modifiers for use in drug target discovery, and direct drug screening. To facilitate research into human disease, we are assembling lists of human disease genes, identifying their fly counterparts, and generating a catalog of stocks at the BDSC that can be used to model a disease or study pathways associated with the disease (http://flystocks.bio.indiana.edu/Browse/HD/HDintro.htm). We will present these efforts as well as give an overview of the many types of collections at the BDSC that can be screened for modifers of your favorite Drosophila human disease model.