We recently found that the neuroblasts (neural precursor cells) undergo morphogenetic changes concomitant with the overlying epidermal cells during C. elegans ventral enclosure. These events occur during mid-embryogenesis, and may help prepare the embryo to subsequently elongate into the long, thin worm. Subsets of neuroblasts are initially distributed as columns across the embryo, and subsequently organize into ring-like patterns, followed by their redistribution into rows that follow the anterior-posterior axis of the embryo. The formation of similar patterns called rosettes is required for the reorganization and elongation of epithelial tissue in other metazoans, which is mediated by myosin activity and changes in adhesion junctions that tether neighbouring cells. In the neuroblasts, we observed the accumulation of myosin foci and changes in the localization of the adhesion junction components E-cadherin and α-catenin during their reorganization. Further, myosin is required in the neuroblasts for ventral enclosure, and we propose that mechanical forces in the neuroblasts influence constriction of the overlying epidermal cells. The formation of at least one of the rosettes coincides with migration of the overlying ventral epidermal cells, and disrupting neuroblast cell division alters epidermal cell migration as well as the distribution of myosin in these cells. Thus, neuroblast morphogenesis could 1) decrease the surface area of the neuroblast substrate, making it easier for the overlying epidermal cells to migrate and/or 2) generate tension that is sensed by the epidermal cells and influences active myosin localization. We are currently testing these models by further analyzing the precise movements and shape changes of the neuroblasts that form the rosette(s), and by monitoring how their disruption influences the overlying epidermal cells. In addition, we are using AFM (atomic force microscopy) to determine if there are changes in tension/elasticity of the neuroblasts during ventral enclosure, and how myosin disruption alters this tension. The coordination of myosin-dependent events and forces between cells in different tissues could be a common theme for coordinating morphogenetic events during metazoan development.