The biological mechanisms by which neural circuits are modulated by an animal’s sex (“gender”) is poorly understood. We have previously found that C. elegans males and hermaphrodites differ in their response to several odorants detected by shared circuitry. In particular, hermaphrodites are more attracted than males to the odorant diacetyl, a food cue sensed by the chemoreceptor odr-10, expressed in the AWA sensory neuron. Recently, we have shown that regulated odr-10 expression underlies sex differences in diacetyl attraction. In adult males, odr-10 expression is significantly reduced compared to hermaphrodites, promoting the prioritization of exploratory behavior over feeding. Moreover, transient starvation upregulates odr-10 in males to promote feeding. We have identified the TGFβ and the insulin-like signaling pathways as regulators of odr-10 expression in males. Males with mutations in the TGFβ ligand daf-7 or the downstream SMAD daf-8 have increased expression of odr-10. In contrast, these mutations have no apparent effect on odr-10 expression in hermaphrodites. Animals with mutations in daf-5, a transcription factor inhibited by DAF-7 signaling, show decreased expression of odr-10; moreover, daf-5 males show no increase in odr-10 expression in response to starvation. Likewise, loss of the insulin receptor daf-2 results in increased odr-10 expression in males and daf-16 mutant males do not upregulate odr-10 upon starvation. These findings suggest the TGFβ and insulin-like signaling pathways regulate feeding-state-mediated changes in odr-10 expression in a sex-dependent manner. The apparent sensitivity of males to these signals suggests that the sex determination pathway intersects with TGFβ and insulin-like signaling to bring about state-dependent changes in odr-10 expression and behavior.