PgmNr Z6273: Atrazine Affects Cartilage and Heart Development in Zebrafish (Danio rerio).

Authors:
C. S. Lassiter; B. S. Walker


Institutes
Roanoke College, Salem, VA.


Abstract:

Atrazine is a commonly used herbicide that has been implicated as an endocrine disrupting compound. Atrazine's role in cartilage and bone formation has yet to be established. Craniofacial cartilage and bone deformities account for a large number of birth defects in the United States.  Zebrafish treated with 1 µM atrazine had gross morphological defects in their cartilage at 5 days post fertilization, while embryos treated with concentrations below 1 µM had cartilage elements with increasingly wide angles, resulting in a shorter, fatter face with increasing atrazine concentration. Further investigations into the heart rate and hatch rate of larvae revealed atrazine leads to increased heart rates and decreased hatch rates in embryonic zebrafish. Future experiments into the effects of atrazine on bone need to be performed in order to gain a better understanding of the overall effects of this chemical.