PgmNr D1143: Cellular senescence and oxidative stress are aging mechanisms that depend on genetic background.

Authors:
P. Bejo; F. Capobianco; J. Parker


Institutes
SUNY Plattsburgh, Plattsburgh, NY.


Keyword: physiology of adult organs

Abstract:

Cellular senescence (CS) is a state of metabolically active cells that experience an irreversible growth arrest upon some type of stress. Recently CS has been tied to age-related diseases (Zhu et al, 2015). Physiological aging is also associated with increased levels of ROS, but it is not understood how senescence and oxidative stress react to induce aging. We assessed the effect of senolytic drugs (that selectively kill senescent cells) on the longevity of wild-type Drosophila melanogaster. In our study, we show that a combination of senolytics (Dasatinib and Quercetin) increase the lifespan of one wild-type line Drosophila melanogaster, with no effect on the other. Previous experiments of our lab show a difference in oxidative stress response between these two genetic backgrounds. We are now using this combination of senolytic drugs and paraquat treatment to understand the relationship between oxidative stress and CS on physiological aging.