PgmNr W4184: Miro and dynein localize mitochondria in the intestine.

Authors:
T. Inoue; H. L. Chua; H. Y. Cheng; Y. Shen


Institutes
National University of Singapore, Singapore, SG.


Keyword: Transportation of intracellular components

Abstract:

We are studying the role of Miro, an atypical small GTPase, in localization of intestinal mitochondria. In the wild-type, intestinal mitochondria are enriched near the apical surface of intestinal cells. We found that a mutation in miro-1 disrupts this localization such that the distribution is more even across the intestinal cell. Using RNAi, we also found that components of the dynein motor protein are involved in this localization. We are carrying out additional experiments to identify other regulators of intestinal mitochondrial localization.



Wormbase Genetic Index
1. miro-1