This poster will present an update on the development of zebrafishbrain.org and is intended to invoke a discussion on the best way forward for neuroanatomical atlasing resources for the zebrafish. Our objective with zebrafishbrain.org has been to create a web-based repository to communicate – in a user-friendly manner – information about the zebrafish brain.
Zebrafishbrain.org consists of annotated 2D projections of confocal data from transgenic and immunohistochemically stained larval zebrafish specimens. Many of these annotated images have also been incorporated into image and video-enriched tutorials about particular structures in the brain. The annotations and tutorials follow the standard ontology provided by ZFIN.org.
Recently, several brain data-registration systems have been independently developed by other groups and most are directed towards mapping expression or activity data to common anatomical frameworks.
We believe it is timely for these various resources to be brought together using one or few standardised approaches to ease the analysis of future anatomical, neuronal activity, and gene expression datasets. We present here some ideas about how best to achieve this through strengthening links between these disparate resources.
In addition, we will also present ideas about how best to generate high-throughput neuronal morphology data for incorporation into a standardised framework in order to build circuit information.