MicroRNAs (miRNAs) are a highly conserved class of non-coding RNAs that regulate essential cellular events such as proliferation and differentiation. The Caenorhabditis elegans (C. elegans) animal model provides a unique opportunity to determine how distinct groups of miRNAs, such as those belonging to the lin-4 and let-7 families, function in overlapping signaling networks during post-embryonic development. lin-4 and let-7 are well characterized and direct cell fate determination in C. elegans during the larval transitions and act as key regulators of temporal gene expression. Additional lin-4 and let-7 family members display overlapping expression patterns in the developing hypodermis and reproductive system in nematodes, and we hypothesize that combinations of miRNAs across these families (and sharing little sequence homology to one another) control common developmental events. Our deletion studies indicated that the lin-4 homologue, miR-237, and the let-7 family members, miR-48 and miR-84, function together likely with chromatin remodeling genes to direct cell cycle progression in the germline as well as formation of the egg-laying structures. Our work also suggested that members within the lin-4 miRNA family, namely lin-4 and mir-237, which share a common “miRNA seed”, functionally compensate when tested in a lin-4 loss-of-function in vivo rescue assay. These studies may provide insight into why mammalian homologues for lin-4 and let-7 are often targeted in a wide range of human cancers.