PgmNr M5028: Analysis of odor identification in 3xTg-AD mice.

Authors:
Lisa S. Webb; Stephen Fink; Quinton Pace; Rachel Schendzielos; Nazifa Khan; Benjamin Genovese; Katie Whitcomb; Emma Croushore; Harold J. Grau; Darlene A. Mitrano


Institutes
Christopher Newport University, Newport News, VA.


Abstract:

Alzheimer’s Disease (AD) is a progressive neurodegenerative disease affecting a significant and growing proportion of the elderly population.  There are several mouse models exhibiting a variety of AD phenotypes on a multiple genetic backgrounds available to study AD.  The model we use is the B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax (3xTg-AD) mouse, a triple transgenic model that develops both the amyloid-b plaques and neurofibrillary (tau) tangles.  Our study aims to provide more information regarding the various cognitive and biochemical characteristics of the 3xTg-AD model compared to the background and parental strains.  Here we report our preliminary data buried food tests examining olfactory effects, specifically the ability to identify (rather than discriminate between) odors.