PgmNr Y3003: How TORC controls growth through metabolism.

Authors:
J. Chen


Institutes
UT Southwestern Medical Center at Dallas, Dallas, TX.


Keyword: Cell Cycle/Growth Control/Metabolism

Abstract:

Nitrogen permease regulator 2 (Npr2) is a conserved negative regulator of target of rapamycin complex 1 (TORC1), which promotes cell growth and proliferation in nutrient-sufficient conditions. Npr2 forms a complex with Npr3 and Iml1, and can function as a GTPase activating protein (GAP) complex for the small GTPases important for TORC1 function. Npr2 is frequently deleted or mutated in cancers, suggesting it plays a critical role in cell growth control. Interestingly, yeast cells lacking Npr2 (npr2∆) can grow faster or slower than wild type in a manner dependent on the growth medium. We dissected the metabolic changes that occur in npr2∆ cells under these different nutrient environments, which has revealed the consequences of deregulated TORC1 signaling in different contexts. These findings have started to help us understand what TORC1 is really doing to cellular metabolism to reciprocally regulate cell growth and autophagy.



Yeast Database Genetic Index
1. gene symbol: Npr2; systematic name: YEL062W