The calcium ion (Ca2+) is a second messenger known to have important roles in regulating physiological processes such as proliferation, apoptosis and cell differentiation. However, how the spatiotemporal properties of Ca2+ transients reflect the underlying physiological state of tissues is still poorly understood. Here we use an established model system of an epithelial tissue, the Drosophila wing imaginal disc, to investigate how tissue properties impact the propagation of Ca2+ transients in simple epithelia. We recently observed oscillatory waves in cultured larval wing discs. A computational model of Ca2+ signaling was developed to explain these oscillatory Ca2+ waves. The computational model predicts that modulating the variance of phospholipase C (PLC) activity leads to multiple signaling regimes that transition from quiescence to coordinated long range waves at the tissue scale to noisy locally uncoordinated Ca2+ transients. As validation of this prediction we confirmed that these predicted regimes can be recapitulated experimentally through manipulating levels of serum-based stimulation. Imposing a pattern of Ca2+ signaling kinetics also explains relative differences in Ca2+ signaling frequencies between the anterior and posterior compartment of the wing disc. This model provides an important basis to computationally test mechanisms of Ca2+ regulation and function in organ development and homeostasis.