Ginkgo biloba extract (GBE), which is rich in antioxidants is often used as an alternative treatment to postpone the development of Alzheimer’s disease (AD) symptoms, but little is known regarding its protective mechanisms. The nematode, Caenorhabditis elegans, is a valuable tool for studying AD because it expresses an APP ortholog, apl-1, which has been implicated in the insulin signaling pathway and in larval development. Our study was two-fold. 1) We examined the touch withdrawal response of C. elegans strains overexpressing apl-1 that were GBE treated and untreated. An eyelash was used to gently tap on the posterior and anterior ends of the nematodes to determine habituation and memory. 2) RNA sequencing was used to determine the expression level of genes affected by GBE in both wild type (N2) and mutant strains. Total RNA was extracted using the Purelink© RNA Mini Kit, while libraries and sequencing were performed at the New York Genome Center. By combining these phenotypic and genotypic methods, we expect to identify genes and mutations responsible for molting and memory defects in this important model species.