Cells death is a key process that is necessary for the maintenance of tissues, and the removal of dangerous or unwanted cells. Apoptosis is one of the best-characterized types of programmed cell death. Membrane blebbing, caspase activation, chromatin condensation, and DNA fragmentation are all hallmarks of apoptosis. The Drosophila ovary is a powerful system to study programmed cell death because this system uses both apoptotic and non-apoptotic mechanisms. During mid-oogenesis, starvation cues reproducibly induce an apoptotic program and in late oogenesis, non-apoptotic programmed cell death occurs developmentally. Upon apoptotic cell death, follicle cells act as non-professional phagocytes to clear the debris. The molecular mechanisms that govern the communication between apoptotic cells and non-professional phagocytes in this system, however, are understudied. We have found that Draper, an engulfment receptor, is required for engulfment by follicle cells in the ovary. Interestingly, when Draper is overexpressed in follicle cells, the germline undergoes programmed cell death. In an effort to understand the underpinnings of engulfment receptor-induced cell death, we sought to characterize the type of cell death and signaling pathways involved in Draper-mediated germline cell death in the Drosophila ovary. Because Draper loss of function mutants elicit defects during cell death in late oogenesis, some of the key regulators of engulfment receptor mediated cell death may function normally during non-apoptotic cell death.