Abuse and addiction to psychostimulants like cocaine and methamphetamine present a worldwide health issue. Drosophila melanogaster presents a model system to identify genetic and transcriptional networks that underlie variation in effects of drug exposure that can serve as a blueprint for subsequent studies on humans. We have derived an outbred advanced intercross population (AIP) from 37 of the sequenced inbred wild-derived lines of the Drosophila melanogaster Genetic Reference Panel (DGRP). The lines are maximally genetically divergent, have minimal residual heterozygosity, are not segregating for common inversions and are not infected with Wolbachia pipientis. We assessed voluntary consumption of 4% sucrose, 4% sucrose + 1 µg/µL cocaine and 4% sucrose + 0.3 µg/µL methamphetamine among 11 of the 37 DGRP lines that were parents of the AIP. We found significant variation among the lines, in both sexes, for consumption of both drugs, with estimates of broad sense heritability for cocaine consumption of H2 = 0.57 (females) and 0.63 (males) and for methamphetamine consumption of H2 = 0.45 (females) and 0.39 (males). Thus, there is genetic variation in the DGRP lines used to construct the AIP for voluntary drug consumption. Further, several DGRP lines consume over twice as much drug + sucrose as sucrose alone, and this phenomenon is both sex- and drug-specific. We will present data from extreme quantitative trait locus genome wide association mapping of cocaine and methamphetamine consumption using the AIP.