Humans cannot regenerate lost or damaged appendages and organs, with all of their complexity, whereas several ectothermic organisms, such as salamanders and teleost fishes, can. After severe cutaneous injuries resulting from burns or other trauma, humans develop discolored scars due to the failure of melanocytes to regenerate at the pre-wound density; such discoloration of scar tissue can be psychologically debilitating even after the acute injury has healed. By contrast, zebrafish can regenerate their melanocyte complement perfectly, even after full-thickness skin wounds. Here, we use high resolution imaging with photo-convertible fluorophores to document the dynamics of individual melanocyte progenitors as they migrate into the wound and populate regenerative tissue, as well as assess roles for candidate pathways in these events. Understanding melanocyte stem cell behavior in an organism that does not develop discolored scars may suggest novel ways to stimulate pigment regeneration in human patients.