Genomic patterns of variation offer powerful insights into the selective conditions that existed in the past. Previous studies highlight the role of rapidly evolving sex and reproductive genes in population divergence and subsequent isolation. Yet whether these highly diverged genes represent population-specific (i.e., local) adapted functional networks is not well understood. Here, we compare the functional landscape of adaptive change across protein-coding genes involved in various aspects of male and female reproduction between two populations of D. melanogaster, an ancestral African population (Gambia) and a more recently derived North American population (Raleigh NC). .