Alzheimer’s Disease (AD) is an age-dependent neurodegenerative disease pathologically characterized by the formation of amyloid plaques and neurofibrillary tangles. Amyloid Beta 1-42 (Aβ1-42) has been shown to be the most likely peptide to form these plaques that ultimately inhibit neuronal communication and induce neuronal death. Drosophila melanogaster is a model organism that has been used to study numerous neurodegenerative diseases including AD, Parkinson’s disease, and ALS. In this study, a Drosophila melanogaster strain expressing human Amyloid Beta 1-42 transgene has been used as an experimental group and a genetically matched line (00C) has served as the control. Previous research has indicated that both exercise and heat shock can increase the lifespan and health span of Drosophila melanogaster. Both Aβ1-42 and 00C strains of Drosophila melanogaster were exercised and heat shocked, each strain was exercised five days a week for three weeks, and heat shocked at 37˚C for twenty minutes twice a week for three weeks. Survival and climbing assays along with heart rate measurements were used to assess lifespan and health span. The survival, climbing, and heart rate assays indicated that exercise and heat shocking the 00C strain improved its lifespan and health span compared to untreated controls while in the Aβ1-42 strain, exercise and heat shock resulted in decreased lifespan, deteriorated health span, and resulted in the impairment of their cognitive capacity compared to the negative control. We’ve found that exercising and heat shocking the 00C strain improved their cognitive and motor functions and thus increased their lifespan and health span. However, exercising and heat shocking the Aβ 1-42 strain resulted in decreased cognitive ability, and motor function, and as such did not benefit their health span. At this point, it is not clear why the Aβ1-42 flies did not benefit from the treatments, as did their matched controls. Future studies will include heart tissue analysis to identify if other biomarkers associated with heart function were compromised.