Psychotropic agents are a loosely defined group of drugs which affect consciousness through pharmacological action on the nervous system. Current psychotropic agents act as anxiolytics, antidepressants, hallucinogens and anesthetics. These compounds may reduce anxiety, relieve pain, and compensate for mental irregularities, but are also responsible for serious complications, including paralysis and death. The discovery of novel psychotropic agents which exhibit high potency and low toxicity remain in high demand. The present study aims to identify the psychotropic potential of novel organic compounds such as quinolone derived trifluoromethyl alcohols and 4-Methylcyclohexanemethanol (MCHM). The behavioral screening of MCHM and quinolone compounds revealed specific defects in motor activity of zebrafish larvae (5 dpf). Our data show that zebrafish larvae treated with MCHM and quinolone derivatives exhibit a reduction in motor activity in lower concentration (1-10uM) exposure. However, at higher concentrations (25uM) it results in loss of balance and failure to respond to touch. The reduction in motor activity is reversible and specific without any toxicity. Simple pharmacokinetic studies reveal that the effects were very rapid, sustained for the entire duration of exposure and reversible up to 72 hours without any toxicity. Further studies with ionic indicators such as CoroNa Green (labels Na+) and DiH-MEQ (labels Cl-) on larvae indicate that these compounds specifically block sodium channels on the mitochondria rich cells at 72 hpf. Therefore, our studies have identified some specific and novel organic compounds with profound and specific pharmacological activity. We are currently characterizing other neuroactivity mechanisms of these compounds such as their ability to modulate other ionic transport channels.