Epistatic interactions underlie foundational problems in evolutionary biology: the role of history and chance in determining the outcomes of evolution, the relative difficulties of evolving different complex adaptations, and the evolution of sex and recombination. To characterize the general patterns of epistasis produced by adaptation, we evolved 20 replicate populations of 36 different yeast gene deletion mutants and measured the epistasis between the initial gene deletions and the mutations acquired in the course of adaptation. We found that rates of adaptation were genotype dependent and sought to explain this result in terms of the measured epistatic effects.