The Hippo signaling pathway regulates organ size and tissue homeostasis in diverse species from Drosophila to mammals. This pathway comprises several tumor suppressors acting in a kinase cascade that ultimately phosphorylates the oncoprotein Yorkie (Yki) or its mammalian counterpart YAP/TAZ. Much of the recent research on Hippo signaling has focused on identifying upstream inputs into the Hippo kinase cascade, elucidating the mechanisms of Yki/YAP/TAZ in transcriptional regulation, and developing small molecule probes and inhibitors targeting the Hippo pathway. Recent work has also expanded the physiological function of Hippo signaling to many biological processes beyond growth control. I will present recent progress in these areas at the GSA meeting.