PgmNr M290: Xist RNA, its interactome, and consequences of their disruption in vivo.

Authors:
Jeannie Lee ¹ ; Lin Yang ¹ ; James Kirby ²

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Institutes
1) HHMI, Harvard Medical School, Massachusetts Gen Hosp, Boston, MA; 2) Beth Israel - Deaconess Medical Center, Harvard Medical Schoo, Boston, MA.

Abstract:

Epigenetic regulation often occurs at the interface between RNA and chromatin. Long noncoding RNAs (lncRNAs) have a special role in epigenetic regulation because they are able to serve as barcodes that target protein complexes to specific genomic addresses. The inactive X chromosome serves as an excellent model by which to investigate the function of lncRNA.  My presentation will focus on how lncRNAs collaborate with protein factors to regulate X-chromosome counting, allelic choice, and the spread of silencing along the inactive X chromosome. I will also discuss the consequences of losing those interactions in the context of development.