- Session Chairs:
- Fernando Pardo-Manuel de Villena, UNC Chapel Hill
- Linda Siracusa, Hackensack Meridian School of Medicine at Seton Hall University
538A
2:00 pm
No more paywalls: cost-benefit analysis across scRNA-seq platforms reveals biological insight is reproducible at low sequencing depths. Kathryn McClelland, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK/NIH)
882C
2:15 pm
Control of target gene specificity in Wnt signaling by transcription factor interactions. Aravindabharathi Ramakrishnan, University of Michigan, Ann Arbor
2217C
2:30 pm
Evolutionary genomics of centromeric satellites in House Mice (Mus). Uma Arora, The Jackson Laboratory
2:45 pm
Reference quality mouse genomes reveal complete strain-specific haplotypes and novel functional loci. Mohab Helmy, EMBL-EBI
887B
3:00 pm
Divergence in KRAB zinc finger proteins is associated with pluripotency spectrum in mouse embryonic stem cells. Candice Byers, The Jackson Laboratory
531C
3:15 pm
Replicability and reproducibility of genetic analysis between different studies using identical Collaborative Cross inbred mice. Yanwei Cai, UNC CHAPEL HILL
3:30 pm
Proteomics reveals the role of translational regulation in ES cells. Selcan Aydin, The Jackson Laboratory for Mouse Genetics
563B
3:45 pm
Super-Mendelian inheritance mediated by CRISPR–Cas9 in the female mouse germline. Hannah Grunwald, University of California San Diego
2103C
4:00 pm
Gene Editing ELANE in Human Hematopoietic Stem and Progenitor Cells Reveals Variant Pathogenicity and Therapeutic Strategies for Severe Congenital Neutropenia. Shuquan Rao, Boston Childrens Hospital
4:15 pm
Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression. Danfeng Cai, Howard Hughes Medical Institute
4:30 pm
Mouse models predict drug combinations to target oncogenes and tumor suppressors. Tyler Peat, National Institutes of Health, National Cancer Institute
573C
4:45 pm
A GxE QTL on Chromosome 15 underlies susceptibility to air pollution-induced lung injury in mice. Adelaide Tovar, The University of North Carolina at Chapel Hill
5:00 pm
Exploring the Genetic Basis for Atrioventricular Septal Defects in Down Syndrome. Yicong Li, Johns Hopkins University School of Medicine
5:15 pm
Elevated canonical WNT signalling disrupts heart development and may underlie cases of human Heterotaxy. Kristen Barratt, The Australian National University
- Session Chairs:
- Denise Montell, University of California, Santa Barbara
- Mark Johnston, University of Colorado and Editor in Chief of GENETICS
Welcome and opening remarks
Cellular Biographies: Reconstructing zebrafish development. Alex Schier, Harvard University
Detecting and Correcting Errors in Mitosis. Sue Biggins, Fred Hutchinson Cancer Research Center
2019 Elizabeth Jones Award for Excellence in Education. Bruce Weir, University of Washington
2019 George Beadle Award. Michael Snyder, Stanford University
Haystack to needle: moving from quantitative to developmental genetics of a reproductive trait. Cassandra Extavour, Harvard University
How can biology and breeding contribute to improving food systems and climate change? Ed Buckler, Cornell University
- Session Chair:
- Jessica Feldman, Stanford University
7
1:30 pm
Different paths to the same cell type. Karolina Mizeracka, Boston Children's Hospital
8
1:45 pm
The role of cell cycle in invasive differentiation behavior of the C. elegans anchor cell. Taylor Medwig-Kinney, Stony Brook University
9
2:00 pm
Single-zygote analysis of protein quantitation reveals high robustness of cell polarisation and asymmetric division to perturbations in PAR protein abundance. Nelio Rodrigues, Francis Crick Institute
10
2:15 pm
PAR polarity proteins direct intracellular tube expansion through apical recruitment of the exocyst complex. Joshua Abrams, NYU School of Medicine
11
2:30 pm
Multi-tissue patterning drives anterior morphogenesis in the C. elegans embryo. Alisa Piekny, Concordia University
- Session Chair:
- Lynn Cooley, Yale University
12
1:30 pm
Meiotic drive and satellite DNA in Drosophila melanogaster. Amanda Larracuente, University of Rochester
13
2:00 pm
GCNA preserves genome integrity and fertility across species. Michael Buszczak, UT Southwestern Medical Center
14
2:30 pm
Larry Sandler Award Presentation. Barbara Mellone
15
2:35 pm
Larry Sandler Award Talk. Balint Kacsoh, Perelman School of Medicine, University of Pennsylvania
16
3:00 pm
Active genetics comes alive. Ethan Bier, Univ California, San Diego
- Session Chair:
- Emily Davenport, Pennsylvania State University
17
1:30 pm
Generation of a robust and clinically-relevant mouse model of Cerebral Cavernous Malformations. Douglas Marchuk, Duke University
18
1:45 pm
ZNF423 patient variants, truncations, and in-frame deletions in mice define an allele and domain-dependent series of midline brain abnormalities. Bruce Hamilton, UC San Diego
19
2:00 pm
Mouse models of an undiagnosed pediatric neurodegenerative disorder. Jay Vivian, University of Kansas Medical Center
20
2:15 pm
Analyzing Hematology by Complete Blood Count in a Genetically Diverse Mouse Population: Changes with Age and Impacts on Mortality Risk. Andrew Deighan, Jackson Laboratory
- Session Chair:
- Dmitri Petrov, Stanford University
21
1:30 pm
The Genomic Landscape of Neanderthal Ancestry in Modern Humans. Arun Sethuraman, California State University San Marcos
22
1:45 pm
Fast estimation of effective migration surfaces. Joseph Marcus, University of Chicago
23
2:00 pm
Reconstructing spatio-temporal patterns of admixture in human history using present-day and ancient genomes. Manjusha Chintalapati, University of California, Berkeley
24
2:15 pm
Recurrent Collection of Drosophila melanogaster from Wild African Environments and Genomic Insights into Species History. John Pool, University of Wisconsin - Madison
- Session Chair:
- Jing Yang, University of Illinois
25
1:30 pm
GEO Data, Human Disease, and Phenotypes on Xenbase: New Tools and Features. Malcolm Fisher, Xenbase (CCHMC)
26
1:45 pm
A genome editing laboratory course for undergrads using CRISPR in butterflies and frogs. Arnaud Martin, George Washington Univ-DC
27
2:00 pm
Differential embryonic gene activation across the subgenomes of Xenopus laevis. Wesley Phelps, University of Pittsburgh
- Session Chairs:
- Helle Ulrich, IMB, Mainz, Germany
- Michael Polymenis, Texas A&M University
28
1:30 pm
Introduction of Nancy Kleckner for the Yeast Genetics Meeting Lifetime Achievement Award. Eric Alani, Cornell University
29
1:35 pm
Meiotic and Mitotic Chromosomes. Nancy Kleckner, Harvard University
30
2:00 pm
GLOE-Seq – a new genomic tool to map replication patterns and DNA lesions with nucleotide resolution. Helle Ulrich, Institute of Molecular Biology gGmbH (IMB)
31
2:15 pm
Systemic Aneuploidization of the Yeast Genome. Lydia Heasley, Colorado State University
32
2:30 pm
Multiple origins of large insertions at chromosomal breaks. Yang Yu, Baylor College of Medicine
33
2:45 pm
Translational control of methionine and serine metabolic pathways underpin the paralog-specific phenotypes of Rpl22 ribosomal protein mutants in cell division and replicative longevity. Michael Polymenis, Texas A&M Univ
- Session Chairs:
- Christian Mosimann, University of Colorado Anschutz Medical Campus
- Mary Mullins, University of Pennsylvania
34
1:30 pm
foxm1 is required for cardiomyocyte proliferation after zebrafish cardiac injury. Daniel Zuppo, University of Pittsburgh
35
1:45 pm
Enhancers and the uneven distribution of regenerative capacities in vertebrates. Wei Wang, Stowers Institute for Medical Research
36
2:00 pm
Robo2 and Type-IV Collagen function in a common molecular pathway to promote target-specific axon regeneration. Patti Murphy, University of Pennsylvania
37
2:15 pm
Characterizing mechanisms of conserved skin appendage formation at single-cell resolution. Lauren Saunders, University of Washington
38
2:30 pm
Single-cell transcriptomic analysis of embryonic vasculogenesis identifies the conversion of Etv2-deficient vascular progenitors into skeletal muscle. Saulius Sumanas, Cincinnati Children's Hospital Medical Center
39
2:45 pm
MicroRNA-mediated control of developmental lymphangiogenesis. Brant Weinstein, NIC HD, NIH
40
3:00 pm
Investigating interactions between the actin and microtubule networks in the yolk cell during zebrafish morphogenesis. Haoyu Wan, University of Toronto
41
3:15 pm
Ectopic kcnh2a slows niche-to-mesenchyme transitions to prolong fin outgrowth and disrupt organ scaling of longfin zebrafish. Kryn Stankunas, University of Oregon
- Session Chair:
- Jordan Ward, University of California, Santa Cruz
42
3:45 pm
Lineage-specific analysis of proliferation-differentiation control in C. elegans. Sander van den Heuvel
43
4:15 pm
Cultivating relationships: genetics and genomics microbiome form and function. Buck Samuel, Baylor College of Medicine
44
4:30 pm
Bicistonic tagging and severing (BiTS): a new gene editing tool in C. elegans using endogenous trans-splicing pathways. Ryan Littlefield, University of South Alabama
45
4:45 pm
Dietary serine enhances chemotherapeutic toxicity through altering the metabolism of the microbiota. Wenfan Ke, The University of Virginia
46
5:00 pm
Rapid Self-Selecting and Clone Free Integration of Transgenes into Engineered CRISPR Safe Harbor Locations in C. elegans. Megan Moerdyk-Schauwecker, University of Oregon
47
5:15 pm
Driving with caution: lessons learned from TIR1 promoters and TIR1 receptor function. Michael Martinez, Stony Brook University
- Session Chair:
- Steve Munger, The Jackson Laboratory
48
3:45 pm
Genome-wide identification and analysis of single nucleotide variants disrupting RNA structure and function. Zhengqing Ouyang, University of Massachusetts Amherst
49
4:00 pm
Structure and function of SWI/SNF complexes is regulated by RNA interactions. Jesse Raab, University of North Carolina at Chapel Hill
50
4:15 pm
Mechanism of monoallelic expression and allelic rheostat role of DNA methylation. Alexander Gimelbrant, Dana-Farber Cancer Institute
- Session Chair:
- Daniel Matute, UNC Chapel Hill
51
3:45 pm
Simultaneous Quantification of mRNA and Protein Levels in Single Cells Reveals Trans-acting Genetic Variation. Christian Brion, University of Minnesota
52
4:00 pm
A mutagenesis survey of a developmental enhancer using automation and robotics reveals constraints on evolvability. Timothy Fuqua, EMBL Heidelberg
53
4:15 pm
From Codons to Ecology – Using Codon Optimization as a Proxy for Gene Expression to Identify Ecologically Adapted Metabolic Pathways. Abigail LaBella, Vanderbilt University
54
4:30 pm
Massively parallel identification of cis-regulatory variants in yeast promoters. Frank Albert, University of Minnesota
55
4:45 pm
Quantifying absolute changes in transcription and translation over 22 years of bacterial adaptation. Premal Shah, Rutgers University
56
5:00 pm
Changes throughout a Genetic Network Mask the Contribution of Hox Gene Evolution. Yang Liu, Johns Hopkins University
- Session Chair:
- Amy Sater, University of Houston
57
3:45 pm
Importance innate-like T cells in tolerance versus resistance to virus and mycobacteria in Xenopus. Jacques Robert, University of Rochester Medical Center
58
4:00 pm
Xenopus tropicalis mutation in the transcription factor six3 reveals its key role in controlling the eye gene regulatory network. Robert Grainger, University of Virginia
59
4:15 pm
The mechanisms of neural crest defects in DDX3X syndrome and related genetic diseases. Shuo Wei, University of Delaware
60
4:30 pm
Modeling Li-Fraumeni Mutations in Xenopus laevis. Amisheila Kinua, Rice University
61
4:45 pm
The CLEAR consortium: elucidating the genetic and cellular basis of trachea-esophageal birth defects. Nicole Edwards, Cincinnati Children's Hospital Medical Center | Center for Stem Cell and Organoid Medicine (CuSTOM)
- Session Chair:
- Anne Spang, University of Basel
62
3:45 pm
Introduction of Doug Koshland for the Lee Hartwell lecture. Phil Hieter, University of British Columbia
63
3:50 pm
Lee Hartwell Lecture: Higher order chromosome structure in yeast, an informative oxymoron then and now. Douglas Koshland
64
4:15 pm
Control of the nucleo-cytoplasmic localization of the yeast mRNA decapping complex. Anne Spang, University of Basel
65
4:30 pm
A stress response allows highly mutated eukaryotic cells to survive and proliferate. Rebecca Zabinsky, Stanford University
66
4:45 pm
ER stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress. Guillaume Thibault, Nanyang Technological University
67
5:00 pm
Generating new orthogonal tRNA and aminoacyl-tRNA synthase pairs in yeast to engineer translation. Stephanie Zimmerman, University of Washington
- Session Chairs:
- Adam Miller, University of Oregon
- Celia Shiau, University of North Carolina at Chapel Hill
68
3:45 pm
Retinoic acid organizes the vagus motor topographic map via spatiotemporal regulation of Hgf/Met signaling. Adam Isabella, Fred Hutchinson Cancer Research Center
69
4:00 pm
The autism- and epilepsy-associated gene Neurobeachin regulates electrical synapse formation via interactions with an intracellular synaptic scaffold. Anne Martin, University of Oregon
70
4:15 pm
Identifying proteins that bind Hmx3a and testing their roles in spinal cord development. William Haws, Syracuse University
71
4:30 pm
Inflammatory signaling regulates neurofibromin 1 (nf1)-dependent habituation learning in larval zebrafish. Andrew Miller, University of Wisconsin-Madison
72
4:45 pm
Dolk regulates motor behaviors through the episodic ataxia-associated protein Kv1.1. Joy Meserve, University of Pennsylvania
73
5:00 pm
Fishing for function in the evolutionary gene pool: a zebrafish model for human-specific duplicated gene SRGAP2. Jose Uribe-Salazar, University of California, Davis
74
5:15 pm
E4bp4-2b/Nfil3-2b contributes to circadian regulation by repressing cryptochrome1aa and period2 expression via the D-box enhancer. Han Wang, Soochow University
370
5:30 pm
Abnormal neuronal positioning affects circuit function in zebrafish. Emilia Asante, University of Missouri
- Session Chair:
- Kailene Simon, Atalanta Therapeutics
75
3:45 pm
Fungal genetics and automated strain engineering at Zymergen. Kenneth Bruno, Zymergen Inc
76
4:05 pm
Making the most of our molecules - a computational framework for unified germplasm characterization and inference. Eli Rodgers-Melnick, Corteva Agriscience
77
4:25 pm
High Yield and Robust Saccharomyces cerevisiae Strains for Biofuel Industry. Celia Payen, DuPont
78
4:45 pm
Divalent siRNA Scaffold for Robust Gene Modulation in the Central Nervous System. Julia Alterman, University of Massachusetts Medical School
79
5:05 pm
NemaMetrix: cutting-edge genome editing and phenotyping tools in C. elegans and zebrafish and how we've targeted parasitic worms. Janis Weeks, NemaMetrix Inc.
This session will highlight some exciting discoveries that advanced from basic research to the marketplace. Attendees will hear how discoveries involving genetic technologies that originated in academic labs moved through the industry pipeline for product development and practical application. This session will consist of five 20-minute talks from industry professionals, followed by a panel discussion featuring the speakers.
- Session Chair:
- Hugo Bellen, Baylor College of Medicine
80
10:00 am
2020 Beadle Award. Julie Ahringer, University of Cambridge
81
10:05 am
2020 Morgan Medal. Gerald Fink, MIT
82
10:10 am
2020 GSA Medal. Bonnie Bassler, HHMI/Princeton University
- Session Chair:
- Maitreya Dunham, University of Washington, Seattle
Tracking SARS-CoV-2 using real-time phylogenetics with nextstrain. Richard Neher, Biozentrum, University of Basel
Getting to community surveillance for COVID-19. Lea Starita, Brotman Baty Advanced Technology Lab, University of Washington
Discussion
- Session Chair:
- Jeffrey Ross-Ibarra, University of California, Davis
107
11:30 am
Negative selection on complex traits limits genetic risk prediction accuracy between populations. Arun Durvasula, UCLA
108
11:45 am
Comprehensive dissection of complex traits using a panel of 250,000 barcoded diploid yeast segregants. Takeshi Matsui, Stanford
109
12:00 pm
Latent phenotypic complexity of adaptation in a single environment. Grant Kinsler, Stanford University
110
12:15 pm
Resolving the genetic basis of simple and complex traits using outbred Hybrid Swarm mapping populations. Cory Weller, National Institutes of Health
111
12:30 pm
Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping. Kerry Geiler-Samerotte, Arizona State University
- Session Chair:
- Nadia Singh, University of Oregon
96
11:30 am
Inclusive PhD admissions: An evidence-based self-education process for faculty, staff and trainees. Scott Barolo, University of Michigan Medical School
97
11:45 am
The Diversity Preview Weekend: A graduate student-led initiative to promote diversity, equity and inclusion in higher education. Andrea Darby, Cornell University
98
12:00 pm
Bridging Worlds for Diversity and Inclusion: Social Science with Biology Education Research Through the iEMBER Network. Gary McDowell, Lightoller LLC
99
12:15 pm
Inclusion of cultural dietary practices in genetics research diversifies the scientific workforce and addresses health disparities. Jennifer Alexander, Fox Chase Cancer Center
100
12:30 pm
For Us, By Us, but Not All of Us: building our own Indigenous biobank as a better way to ensure research equity. Krystal Tsosie, Native BioData Consortium
- Session Chair:
- Karen Arndt, University of Pittsburgh
85
11:30 am
RSC readies the quiescent genome for rapid hypertranscription. Christine Cucinotta, Fred Hutchinson Cancer Research Center
86
11:45 am
How cell size controls genome activation and orchestrates fate decisions. Hui Chen, University of Pennsylvania
87
12:00 pm
Quantitative analysis of transcription factor binding and expression using calling cards reporter arrays. Jiayue Liu, Washington University in St. Louis
88
12:15 pm
Transcription rate modulation by network-level feedback promotes robust patterning outcomes. Shawn Little, Univ. of Pennsylvania Perelman School of Medicine
89
12:30 pm
Shadow enhancers can suppress input transcription factor noise through distinct regulatory logic. Rachel Waymack, University of California, Irvine
- Session Chairs:
- Kari Lenhart, Drexel University
- Kellee Siegfried, University of Massachusetts
90
11:30 am
Stem cell niche exit in C. elegans via orientation and segregation of daughter cells by a cryptic cell outside the niche. Kacy Gordon, UNC Chapel Hill
91
11:45 am
Sex-specific ecdysone signaling is established by Doublesex to regulate gonad stem cell niche development. Lydia Grmai, Johns Hopkins University
92
12:00 pm
Axon-like projections direct the self-renewal versus differentation cell fate decision in Follicle Stem Cells of the Drosophila ovary. Alana O'Reilly, Fox Chase Cancer Center
93
12:15 pm
Novel LOTUS-domain proteins recruit C. elegans Vasa to germ granules and are essential for developmental switches in the germline. Patricia Giselle Cipriani, New York University
94
12:30 pm
Courtship is a two-way conversation: Yeast mating as a model of cell-cell communication. Manuella Clark-Cotton, Duke University
95
12:45 pm
GCNA interacts with Spartan and Topoisomerase II to regulate genome stability. Michelle Carmell, Wellesley College
- Session Chair:
- Clare Smith, Duke University
101
11:30 am
A muscle-to-oenocyte Pvf1 signaling axis protects against obesity. Arpan Ghosh, Harvard Medical School
102
11:45 am
Tell me how to go: The migration mechanisms of cell dissemination in vivo. Alejandra Cabrera, University of Washington
103
12:00 pm
Multidisciplinary Analysis of patient-specific genetic interactions reveal a role for Megalin / LRP2 in Hypoplastic Left Heart Syndrome. Georg Vogler, Sanford Burnham Prebys Medical Discovery Institute
104
12:15 pm
Investigating stage dependent immune tolerance to heterologous cells for the purpose of creating humanized zebrafish. Anna Zdunek, Georgetown University
105
12:30 pm
The C. elegans model organism screening center for the NIH Undiagnosed Disease Network. Tim Schedl, Washington University School of Medicine
106
12:45 pm
SCO-spondin defects and neuroinflammation identified as conserved mechanisms driving severe spine deformity across genetic models of idiopathic scoliosis. Chloe Rose, The Hospital for Sick Children
- Session Chair:
- Jessica Feldman, Stanford University
131
1:30 pm
Visualizing the metazoan proliferation-differentiation decision in vivo. Rebecca Adikes, Stony Brook University
132
1:45 pm
NudC phosphorylation silences dynein to promote anterograde cargo transport in axons. Katie Drerup, NICHD
133
2:00 pm
RNA nucleates phase separation of glycolysis enzymes in yeast in hypoxia. Gregory Fuller, Johns Hopkins University
134
2:15 pm
Degron-tagged reporters probe membrane topology and enable the specific labelling of membrane-wrapped structures. Ann Wehman, Univ Wuerzburg
135
2:30 pm
Cell competition regulates tissue growth and tumorigenesis via non-autonomous induction of autophagy. Rina Nagata, Kyoto University
- Session Chair:
- Miler Lee, University of Pittsburgh
118
1:30 pm
Systematic humanization of yeast processes to understand human biology and disease. Aashiq Kachroo, Concordia University
119
1:45 pm
MAGIC: Mosaic Analysis by gRNA-Induced Crossing Over. Sarah Allen, Cornell University
120
2:00 pm
A Multiplexed CRISPR Screen for Essential microRNA-Target Interactions in C. elegans. Bing Yang, NIH/NIDDK
121
2:15 pm
CRISPR-Cas13d induces efficient mRNA knock-down in animal embryos. Gopal Kushawah, Stowers institute for medical research
122
2:30 pm
A Catalog of Polymorphic SINEC_Cf Insertions in the Dog Genome. Jessica Choi, La Sierra University
- Session Chairs:
- Rob Ward, University of Kansas
- Julie Hall, Lincoln Memorial University
- Nicole Green, University of Iowa
126
1:30 pm
Undergraduate Platform Keynote Address. Elaine Fuchs, Rockefeller University
127
2:00 pm
Characterizing protein aggregates in NUAK mutants using the Drosophila muscle tissue model. Marta Stetsiv, Kansas State University
128
2:15 pm
Alternative mec-2 isoforms exhibit neuron type-specific expression and function. Canyon Calovich-Benne, Southern Methodist University
129
2:30 pm
Distinguishing Between Self and Foreign siRNA in the C. elegans Germline. Diljeet Kaur, Rutgers University
130
2:45 pm
PRISM-stop targeted integration in aquaporin1a1 and 1a2 reveals a requirement during vascular morphogenesis. Jacklyn Levey, Iowa State University
- Session Chair:
- Bret Payseur, University of Wisconsin at Madison
112
1:30 pm
Introduction to James Crow. Bret Payseur
113
1:45 pm
Natural selection on the Arabidopsis thaliana genome in present and future climates. Moises Exposito-Alonso, Carnegie Institution for Science, Stanford University
114
2:00 pm
Quantifying selection on heritable variation in human complex traits. Yuval Simons, Stanford University
115
2:15 pm
Recombination, variance in genetic relatedness, and selection against introgressed DNA. Carl Veller, Harvard University
116
2:30 pm
Predicted shifts in dominance increase the likelihood of soft selective sweeps. Pavitra Muralidhar, Harvard University
117
2:45 pm
Adaptive evolution at a meiosis gene mediates species differences in the rate and patterning of recombination. Cara Brand, University of Pennsylvania
- Session Chair:
- Mary Mullins, University of Pennsylvania
123
1:30 pm
Overview. Mary Mullins, University of Pennsylvania
124
1:40 pm
Institute and Study Section Assignments. Sharon Gubanich, NIH/CSR
125
1:55 pm
The Ins and Outs of NIH Peer Review. Lystranne Maynard-Smith, NIH
- Session Chair:
- Matthew Olson, National Science Foundation
137
2:30 pm
NSF BIO’s COVID-19 response and funding opportunities. Joanne Tornow and Joanna Shisler, NSF
139
2:40 pm
Overview of NIH Extramural Response to COVID-19 Pandemic. Michael Lauer and Jodi Black, NIH
- Session Chair:
- Florian Steiner, University of Geneva
141
3:45 pm
The Argonaut NRDE-3 and MET-2 redundantly target SET-25 to full length transposable elements. Susan Gasser
142
4:15 pm
Regulation of alternative splicing in tissues and distinct neuronal subtypes in C. elegans. John Calarco, University of Toronto
143
4:30 pm
A temporally regulated switch from non-canonical to canonical Wnt signaling stops QR descendant migration through a Slt/Robo and RGA-9/RhoGAP dependent mechanism. Erik Schild, Hubrecht Institute
144
4:45 pm
Repressive H3K9me2 protects lifespan against the transgenerational burden of germline transcription in C. elegans . Teresa Lee, Emory University
145
5:00 pm
In vivo regulation of an X-specific condensin’s binding dynamics in C. elegans. Sevinc Ercan, New York University
146
5:15 pm
A neuronal thermostat controls membrane fluidity in C. elegans. Laetitia Chauve, babraham institute
- Session Chairs:
- Nancy Bonini, University of Penn
- Heinrich Jasper, Buck Institute/Genentech
- Lindsey Goodman, Baylor College of Medicine
147
3:45 pm
Epithelial homeostatic mechanisms prevent tumorous overgrowth by causing the extrusion of RasV12 expressing clones. Jamie Lahvic, University of California, Berkeley
148
4:00 pm
Polyploidy in the adult Drosophila brain. Shyama Nandakumar, University of Michigan
149
4:15 pm
A Drosophila model of Kras/Lkb1 tumorigenesis uncovers oncogenic Kras levels as a key determinate in malignant transformation. Melissa Gilbert-Ross, Emory University School of Medicine
150
4:30 pm
Resolving the contribution of the microbiome in aging. Arvind Shukla, National Institutes of Health
151
4:45 pm
YAP/TAZ transcription co-activators create therapeutic vulnerability in EGFR mutant glioblastoma. Renee Read, Emory University School of Medicine
152
5:00 pm
Tumors kill hosts through inflammatory disruption of the blood-brain barrier in Drosophila. Jung Kim, University of California, Berkeley
153
5:15 pm
Occluding Junction Modulation in Aging and Disease. Anna Salazar, Christopher Newport University
154
5:30 pm
The insulin-like peptide Dilp6 is a key factor to inhibit growth in Drosophila in response to Toll signaling. Miyuki Suzawa, University of Virginia
- Session Chairs:
- Melissa Harrison, University of Wisconsin
- Daniel McKay, UNC Chapel Hill
- Brent Graveley, University of Connecticut
- Stein Aerts, VIB
155
3:45 pm
OVO-B, but not OVO-A, is required for female germ cell viability and has downstream targets in addition to otu in the female germline. Leif Benner, National Institutes of Health
156
4:00 pm
Genome activation and transcriptome diversity: A dual sex-specific role for the Drosophila Clamp protein in splicing and transcription during early embryonic development. Mukulika Ray, Brown University
157
4:15 pm
Tissue-specific chromatin occupancy by the pioneer factor Zelda in Drosophila melanogaster. Elizabeth Larson, University of Wisconsin at Madison
158
4:30 pm
Sex-dependent and sex-independent controls of size variation in natural populations. Hirokazu Okada, ETH Zurich
159
4:45 pm
A functional investigation of conserved cryptic peptides encoded by smORFs identifies two novel mitochondrial components. Justin Bosch, Harvard Medical School
160
5:00 pm
Evolutionary conservation and divergence of 3D genome organization in Drosophila. Nicole Torosin, University
161
5:15 pm
Transcribing loci in close proximity do not share a Pol II hub. Shao-Kuei Huang, New York University
- Session Chair:
- Michelle Southard-Smith, Vanderbilt University Medical Center
162
3:45 pm
Modeling gene x treatment effects in the Collaborative Cross and other replicable multiparent populations. William Valdar, University of North Carolina at Chapel Hill
163
4:00 pm
Genetic dissection of initial cocaine sensitivity and behavioral sensitization using the Collaborative Cross and Diversity Outbred mouse populations. Sarah Schoenrock, University of North Carolina at Chapel Hill
164
4:15 pm
the genetic architecture of insulin secretion. Gary Churchill, The Jackson Laboratory
165
4:30 pm
Controlling phenotypic variability and reproducibility through characterization and stable control of the microbiome in mouse models. James Amos-Landgraf, University of Missouri
- Session Chair:
- Felicity Jones, Friedrich Miescher Laboratory of the Max Planck Society
166
3:45 pm
A chromosomal inversion underlies forest adaptations in deer mice. Olivia Meyerson, Harvard University
167
4:00 pm
RNAi pathways repress reprogramming of C. elegans germ cells during heat stress. Alicia Rogers, University of Southern California
168
4:15 pm
The making of the monarch: A constrained adaptive path to toxin resistance. Marianthi Karageorgi, UC Berkeley
169
4:30 pm
Human isolates of S. cerevisiae: colonization, pathogenicity, and in-host microevolution viewed through domestication history. Walter Pfliegler, University of Debrecen
170
4:45 pm
Learning the properties of adaptive regions with functional data analysis. Mehreen Mughal, Pennsylvania State University
171
5:00 pm
Genome-wide association study (GWAS) of bleaching tolerance in a Great Barrier Reef coral. Zach Fuller, Columbia
- Session Chair:
- Jacques Robert, University of Rochester
172
3:45 pm
Deep cytoplasmic sorting during Xenopus oocyte-to-embryo transition. Jing Yang, University of Illinois
173
4:00 pm
A Spatial Gradient of Cell Size Controls Genome Activation and Contributes to Vertebrate Early Development. Wenchao Qian, University of Pennsylvania
174
4:15 pm
Functional analysis of Noggin-like genes. Prashath Karunaraj, University of Otago
- Session Chairs:
- Brenda Andrews, University of Toronto
- Benoit Kornmann, University of Oxford
175
3:45 pm
Introduction of Michael Snyder for the Winge-Lindegren Address. Michael Knop, University of Heidelberg
176
3:50 pm
Winge-Lindegren Address given by Mike Snyder, Stanford Univeristy. Michael Snyder, Stanford Univeristy
177
4:35 pm
A high throughput method to assay mutation rate: Determining the pathogenicity of Msh2 variants associated with Lynch syndrome. Anja Ollodart, University of Washington
178
4:50 pm
Onyx: A benchtop platform for massively parallel editing of the yeast genome. Nandini Krishnamurthy, Inscripta
- Session Chairs:
- David Grunwald, University of Utah
- Brian Ciruna, The Hospital for Sick Children, Toronto, ON
179
3:45 pm
Optimization of a high-throughput platform for the morphological and behavioral characterization of zebrafish larvae. Megan Dennis, University of California Davis
180
4:00 pm
NTR 2.0: an improved nitroreductase targeted cell ablation system. Jeff Mumm, Johns Hopkins University
181
4:15 pm
A Comparison of CRISPR/Cas9-Based Methods for Creating Amino Acid Substitutions in Zebrafish. Yvonne Rosario, NIH
182
4:30 pm
pGTAG and pPRISM: Two expanded tool sets for using short regions of homology for precise DNA integration at CRISPR/Cas9 cut sites. Jeffrey Essner, Iowa State University
183
4:45 pm
Chemoptogenetic Induction of Neuronal Mitochondrial Damage in vivo. Binxuan Jiao, University of Pittsburgh
184
5:00 pm
Defining zebrafish oogonial stem cells and their somatic cell niche at single-cell resolution. Bruce Draper, University of California, Davis
185
5:15 pm
scRNAseq developmental trajectories to investigate differentiation. Jeffrey Farrell, National Institute of Child and Human Development
186
5:30 pm
Zebrafish CRISPR screening validates and classifies a set of novel candidate genes for human congenital heart defects. Lisa Maves, Seattle Children's Research Institute
- Session Chair:
- Denise Montell, University of California, Santa Barbara
187
10:00 am
2019 Thomas Hunt Morgan Medal. Dan Hartl, Harvard University
188
10:05 am
2020 Edward Novitski Prize. Welcome Bender, Harvard Medical School
189
10:10 am
2020 Elizabeth Jones Award for Excellence in Education. Seth Bordenstein, Vanderbilt University
- Session Chair:
- Denise Montell, University of California Santa Barbara
190
10:30 am
GSA Welcome. Denise Montell, University of California Santa Barbara
191
10:31 am
Gruber Foundation Welcome. A. Sarah Hreha, The Gruber Foundation
192
10:33 am
Presentation of 2020 Gruber Foundation Genetics Prize. Allan Spradling, Carnegie Institution/HHMI
193
10:36 am
Quorum-sensing communication: from viruses to bacteria to eukaryotes. Bonnie Bassler, HHMI/Princeton University
- Session Chairs:
- Lindsey Barske, Cincinnati Children's Hospital Medical Center
- Jing Yang, University of Illinois
194
11:30 am
Dynamic self-generation of FGF morphogen gradients by cytonemes during Drosophila tracheal patterning. Lijuan Du, University of Maryland
195
11:45 am
The BMP signaling gradient is interpreted as concentration thresholds during dorsal-ventral patterning of the embryonic axis. Hannah Greenfeld, University of Pennsylvania
196
12:00 pm
Localized and tissue-wide gene expression changes during regeneration of Drosophila imaginal discs revealed by single-cell analysis. Melanie Worley, Univ California, Berkeley
197
12:15 pm
Epithelial integrity monitoring via ligand-receptor segregation ensures malignant cell elimination. Geert de Vreede, Univ California, Berkeley
198
12:30 pm
Cell competition as a selection against aneuploid cells. Nicholas Baker, Albert Einstein Col Med
199
12:45 pm
Genetic basis and evolutionary context for structural color shift in the Buckeye butterfly (Junonia coenia). Rachel Thayer, University of California, Berkeley
- Session Chair:
- Kerri Kinghorn, University College London
207
11:30 am
Probing the Mechanism of ROS-induced Lipid Droplet formation and Implications for Alzheimer’s disease. Matthew Moulton, Baylor College of Medicine
208
11:45 am
Single Cell Transcriptomics Reveals Misregulated Cellular and Molecular Networks in a Mouse Model of Fragile X Syndrome. Elisa Donnard, University of Massachusetts Medical School
209
12:00 pm
Downregulation of innate immunity suppresses seizures in prickle mutants. Krishna Madhav Nukala, University of Iowa
210
12:15 pm
Creating and Understanding Next-Generation Mouse Models of Alzheimer’s Disease. Gregory Carter, The Jackson Laboratory
211
12:30 pm
Genome-wide discovery of human-gene toxicity modifiers of α-synuclein. Ishita Haider, Wright State University
368
12:45 pm
TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+. Thomas Lloyd, Johns Hopkins School of Medicine
- Session Chair:
- C. Brandon Ogbunu, Brown University
218
11:30 am
Attacks on genetic privacy via uploads to genealogical databases. Michael Edge, UC Davis
219
11:45 am
A Drosophila telomere protein evolves adaptively to contain telomeric retrotransposons. Mia Levine, University of Pennsylvania
220
12:00 pm
Identifying sites under positive selection on viral proteins. Jonathan Mah, University of Washington
221
12:15 pm
Mutualistic interactions shape adaptation in a model yeast-algae community. Sandeep Venkataram, University of California, San Diego
222
12:30 pm
Most cancers carry a substantial deleterious load due to Hill-Robertson interference. Susanne Tilk, Stanford University
- Session Chair:
- Aashiq Kachroo, Concordia University
212
11:30 am
Large-scale phenotypic profiling of yeast subcellular compartments using high-content screening at single-cell resolution. Mojca Mattiazzi Usaj, University of Toronto
213
11:45 am
The design and assembly of synthetic yeast chromosome VIII. Stephanie Lauer, NYU Langone
214
12:00 pm
Quantifying material tissue properties in cellularizing Drosophila embryo using soft bendable cantilevers. Konstantin Doubrovinski, UT Southwestern
215
12:15 pm
Mapping cell types and gene regulatory networks in the developing Drosophila brain using single-cell transcriptomics and epigenomics. Jasper Janssens, VIB-KU Leuven Center for Brain & Disease Research
216
12:30 pm
Light-dependent spatiotemporal control of gene expression a la carte: from discrete patterns to emoji-like shapes. Lorena de Mena, University of Florida
217
12:45 pm
Defining the Geometry of Life Across Model Organisms as a Unifying Framework for Computational Phenomics. Keith Cheng, Penn State Col Med
- Session Chairs:
- Justin DiAngelo, Penn State Berks
- Te-Wen Lo, Ithaca College
- Jenny Knight, Univ of Colorado, Boulder
200
11:30 am
Bear Hair Snares & DNA: Impact of Collaborative Instruction on Molecular Genetics and Mammalogy Students. Julie Hall, Lincoln Memorial University
201
11:45 am
Promoting learning and learner -centered teaching of genetics and bioinformatics with the Assessment Evaluation Rubric. Rochelle Tractenberg, Georgetown University and the Collaborative for Research on Outcomes and -Metrics
202
12:00 pm
The Genomics Education Alliance: scalable, sustainable Infrastructure for undergraduate course-based research experiences. Jason Williams, Cold Spring Harbor Laboratory
203
12:15 pm
Crowd-sourcing CRISPR: A course-based research project to investigate the impact of chromatin environment on double-strand break repair while enhancing student learning. Rebecca Burgess, Stevenson University
204
12:30 pm
The Pipeline CURE: an iterative approach to introduce all students to research throughout a biology curriculum. Teresa Lee, Emory University
205
12:45 pm
Performance-Enhanced Biology: an interdisciplinary and inter-institutional experiment in science literacy and communication. Luke Ziegler, Bemidji State
- Session Chair:
- Julie Claycomb, University of Toronto
235
1:40 pm
Unraveling the influence of sequence features and position on uORF activity using massively parallel reporter systems and machine learning. Joel McManus, Carnegie Mellon University
236
1:55 pm
Codon usage bias in a complex multicellular organism: one size does not fit all. Scott Allen, Duke University
237
2:10 pm
The splicing factor SFPQ represses the formation of cryptic last exons. Pat Gordon, King's College London
238
2:25 pm
Splicing takes place as RNA polymerase II transcribes past recursive and canonical splice sites in the developing Drosophila embryo. Rui Gonçalo Martinho, University of Aveiro
239
2:40 pm
mRNAs targeted by silencing small RNAs accumulate in P granules. John Paul Ouyang, Johns Hopkins University School of Medicine
240
2:55 pm
Functional evolution of noncoding RNA for mammalian dosage compensation. Sha Sun, Univ California, Irvine
241
3:10 pm
RNA abasic sites in yeast and human cells. Vivian Cheung, HHMI
- Session Chair:
- Brian Calvi, Indiana University, Bloomington
248
1:40 pm
Evolutionarily conserved pathways prevent mislocalization of CENP-A and chromosomal instability (CIN) in yeast and human cells. Munira Basrai, NCI/NIH
249
1:55 pm
Rif1 functions in a tissue-specific manner to control replication timing through its PP1-binding motif. Jared Nordman, Vanderbilt University
250
2:10 pm
Evidence of pervasive DNA replication mediated class of CNVs. Pieter Spealman, New York University
251
2:25 pm
Polymerase theta protects against detrimental mitotic recombination. Juan Carvajal-Garcia, University of Nroth Carolina at Chapel Hill
252
2:40 pm
Chromatin modifiers alter repair/rejection outcomes during homologous recombination in S. cerevisiae. beata mackenroth, Cornell University
253
2:55 pm
Regulation of sister chromatid repair maintains genomic integrity during meiosis. Erik Toraason, University of Oregon
254
3:10 pm
The meiosis-specific cohesin subunit Rad21l1 is required for oogenesis but is dispensible for spermatogenisis in zebrafish. Sean Burgess, Univ California, Davis
255
3:25 pm
Delineation of the SUMO-Modified Proteome Reveals Regulatory Functions Throughout Meiosis. Neil Hunter, Univ California, Davis / HHMI
- Session Chairs:
- Julie Dallman, University of Miami
- Max Heiman, Harvard University
242
1:40 pm
The primary cilia gene Ttc21b modulates forebrain and orofacial development as a crucial ciliopathy gene. Rolf Stottmann, Cincinnati Children's Hospital Medical Center
243
1:55 pm
Unique homeobox codes delineate all neuron classes of the nematode Caenorhabditis elegans. Molly Reilly, Columbia University
244
2:10 pm
Axonal initial segment-like regions are localized distal to the intersection of dendrites and axons in active Drosophila neurons. Thomas Ravenscroft, Baylor College of Medicine
245
2:25 pm
Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring. Ferdi Ridvan Kiral, Free University Berlin
246
2:40 pm
Neuropeptide VF Neurons Promote Sleep via the Serotonergic Raphe. Daniel Lee, California Institute of Technology
247
2:55 pm
Feedback between sensorimotor and neuromodulatory circuits enables flexible selection of behavioral states in C. elegans. Steven Flavell, Massachusetts Institute of Technology
- Session Chair:
- Kelley Harris, University of Washington
223
1:40 pm
Temperature-dependent phenotypic effects of house fly proto-Y chromosomes explain the maintenance of polygenic sex determination in natural populations. Kiran Adhikari, University of Houston
224
1:55 pm
Gene-by-diet interactions modulate the landscape of transcriptional response of individual fruit flies. Luisa Pallares, Princeton University
225
2:10 pm
Sign inversion in selection on modifier mutations. Yevgeniy Raynes, Brown University
226
2:25 pm
Goldilocks and the Three Genotypes: Characterizing the Prevalence of Overdominance for Adaptive Mutations that Arise in Diploids. Vivian Chen, Stanford University
227
2:40 pm
Evolutionary modification of dominance reversal under seasonal antagonism. Evgeny Brud, University of Pennsylvania
- Session Chairs:
- Shinya Yamamoto, Baylor College of Medicine
- Andy Golden, NIH
- Koichi Kawakami, NIG-Japan
228
1:40 pm
The essential role of model organisms for functional studies of genes and variants linked to human diseases. Ada Hamosh, John Hopkins University
229
1:55 pm
Solving difficult to diagnose diseases using flies and zebrafish: the Model Organisms Screening Centers of the Undiagnosed Diseases Network. Hugo Bellen, Neurological Research Institute
230
2:10 pm
The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes for Rare Diseases to Functional Characterization Research in Model Organisms. Phil Hieter, University of British Columbia
231
2:25 pm
Leveraging the International Mouse Phenotyping Consortium in collaborative research. Lauryl Nutter, The Hospital for Sick Children
232
2:40 pm
Modeling rare monogenic human diseases in C. elegans. Andy Golden, NIDDK/NIH
233
2:55 pm
A model organism-based drug discovery pipeline for amyotrophic lateral sclerosis. Alex Parker, CRCHUM, University of Montreal
234
3:10 pm
Strategies and resources to facilitate direct collaborations between clinicians and model organism researchers on a global scale. Shinya Yamamoto, Baylor College of Medicine
- Session Chair:
- Sasha Levy, Stanford University
270
3:45 pm
A distinct class of condensin II sites are required to establish long-range interactions between distal heterochromatic sites following mitotic exit. Randi Isenhart, University of Pennsylvania
271
4:00 pm
Functional Analysis of the Mysterious Germline-Restricted Chromosome in Zebra Finch (Taeniopygia guttata). Kathryn Asalone, American University
272
4:15 pm
DeepArk: sequence-based models of cis-regulatory logic for model organisms. Evan Cofer, Princeton University
273
4:30 pm
Biological Robustness: genetic compensation and transcriptional adaptation. Didier Stainier, Max Planck Institute for Heart and Lung Research
274
4:45 pm
The dynamics of global acetylation remodeling during the yeast heat shock response. Jeff Lewis, University of Arkansas
275
5:00 pm
Disome profiling reveals genome-wide targets of ribosome quality control. Nicholas Guydosh, NIDDK/NIH
276
5:15 pm
A large accessory protein interactome is rewired across environments. Sasha Levy, Stanford University
- Session Chair:
- Teresa Gunn, McLaughlin Research Institute
262
3:45 pm
Single cell sequencing the lateral plate mesoderm origins of mesothelial membranes. Christian Mosimann, University of Colorado School of Medicine
263
4:00 pm
Regulation of blood cell transdifferentiation by oxygen sensing neurons through atypical guanylyl cyclases. Katja Brückner, University of California San Francisco
264
4:15 pm
Molecular regulation of vascular smooth muscle cell recruitment to arteries during development. Amber Stratman, Washington University School of Medicine
265
4:30 pm
The sexy heart: sex-specific differences during mouse cardiac development. Nora Engel, Temple University
266
4:45 pm
Endocardial cell dynamics, modulated by cardiac function and Acvrl1a signaling, shape the cardiac outflow tract. Pragya Sidhwani, University of California, San Diego
267
5:00 pm
Cholinergic nerve dependent regeneration in the gut. Afroditi Petsakou, Harvard Medical School
268
5:15 pm
A role for PAR polarity proteins in microtubule reorganization as intestinal epithelial cells divide. Maria Sallee, Stanford University
269
5:30 pm
An abundant quiescent stem cell population protects principal cells from kidney stones in adult Drosophila Malpighian tubules. Chenhui Wang, Carnegie Institution for Science
- Session Chairs:
- Amanda Amodeo, Princeton University
- Sally Horne-Badovinac, University of Chicago
277
3:45 pm
Patched regulates lipid homeostasis by controlling cellular cholesterol levels. Anne Spang, University of Basel
278
4:00 pm
Pla2g12b affects serum cholesterol levels via the lipoprotein biogenesis pathway. James Thierer, Carnegie Institution for Science
279
4:15 pm
ERM-1 phosphorylation and NRFL-1 redundantly control lumen formation in the C. elegans intestine in concert with the Ste20-like kinase GCK-4. Mike Boxem, Utrecht University
280
4:30 pm
Connecting the lamin dots: Lmnl3 orchestrates chromosome segregation and replication timing during zebrafish cleavage stages. Dana Klatt Shaw, Washington University in St. Louis
281
4:45 pm
Ire1 Phosphorylates Pumilio to protect XBP1 mRNA from RIDD. Fatima Cairrao, ITQB-UNL
282
5:00 pm
Phenomic screen implicates the yeast lysine acetyltransferase NuA4 in regulation of glycogen synthesis and mitochondrial morphology through the PKA inhibitor Bcy1. Elizabeth Walden, University of Ottawa
283
5:15 pm
Translational induction of ATF4 mRNA during Integrated Stress Response requires noncanonical initiation factors eIF2D and DENR. Hyung Don Ryoo, New York University SoM
284
5:30 pm
α-Arrestins Regulate Autophagy. Allyson O'Donnell, University of Pittsburgh
- Session Chair:
- Emily B. Josephs, Michigan State University
256
3:45 pm
Characterizing strong adaptation in an admixed population over 20 generations. Amy Goldberg, Duke University
257
4:00 pm
Decoding wheat adaptation by genus-level population sequencing. Fei Lu, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
258
4:15 pm
The genomic basis of adaptation in a ninety year long barley experiment. Daniel Koenig, University of California Riverside
259
4:30 pm
The strength and pattern of natural selection on rice gene expression. Simon Groen, New York University
260
4:45 pm
Fitness and environmental patterns in maize landraces identify beneficial alleles at single gene resolution. Daniel Gates, UC Davis
261
5:00 pm
A full-likelihood method to disentangle selection on genetically-correlated traits using whole-genome genealogies. Aaron Stern, UC Berkeley
- Session Chair:
- Terry Magnuson, University of North Carolina, Chapel Hill
Stem Cells In Silence, Action and Cancer. Elaine Fuchs, Rockefeller University
2020 Morgan Medal. David Botstein, Calico Labs
A liquid-like organelle at the root of motile ciliopathy. John Wallingford, University of Texas, Austin
- Session Chair:
- Diana Chu, San Francisco State University
288
11:00 am
Lessons learned from a genetic law-breaker. Diane Shakes
289
11:30 am
mRNA localization is linked to translation regulation in the Caenorhabditis elegans germ lineage. Dylan Parker, Colorado State University
290
11:45 am
DNA damage repair is altered in aging C. elegans oocytes. Victoria Adler, University of Oregon
291
12:00 pm
SPE-36 is an EGF-motif containing secreted sperm protein required for fertilization in C. elegans. Amber Krauchunas, Rutgers University
292
12:15 pm
DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence. E Hubbard, New York Univ Sch Medicine
293
12:30 pm
Effects of Polyploidy in C. elegans. Mara Schvarzstein, City University of New York, Brooklyn College and The Graduate Center
- Session Chairs:
- Mary Baylies, MSKCC
- Nic Tapon, Francis Crick Institute
- Melanie Worley, UC Berkeley
294
11:00 am
Intercellular feedback in the growing Drosophila germline cluster. Caroline Doherty, Princeton University
295
11:15 am
A new conserved modulator of immune cell tissue invasion induces a metabolic program through concerted shifts in transcription and translation. Daria Siekhaus, Institute of Science and Technology Austria
296
11:30 am
Positioning a stem cell niche during organogenesis. Lauren Anllo, University of Pennsylvania
297
11:45 am
Ecdysone dependent maturation of the epithelial barrier limits Dilp8 signaling in Drosophila wing imaginal discs. Danielle DaCrema, University of Virginia
298
12:00 pm
The Integrity of the mitotic nuclear lamina is required for stem cell maintenance. Tingting Duan, University of Iowa
299
12:15 pm
Cells with loss-of-heterozygosity after exposure to ionizing radiation in Drosophila are culled by p53-dependent and p53-independent mechanisms. TinTin Su, University of Colorado
300
12:30 pm
Rescue of a missing heart: The role of ribosomal proteins in congenital heart disease. Tanja Nielsen, Sanford Burnham Prebys Medical Research Institute
- Session Chairs:
- Bassem Hassan, ICM Paris
- Robin Hiesinger, Freie U Berlin
- Kate O'Connor-Giles, Brown University
- Giorgio Gilestro, Imperial College London
- Leif Benner, NIH/NIDDK
301
11:00 am
Non-autonomous regulation of Drosophila neuroblast proliferation via glia lipid mediated hedgehog signalling. Qian Dong, The University of Melbourne
302
11:15 am
Walking and Singing: Closed-loop modulation of Drosophila song. Osama Ahmed, Princeton University
303
11:30 am
Proteomics of protein trafficking by in vivo tissue-specific labeling. Ilia Droujinine, Harvard Medical School
304
11:45 am
Microbiome High-throughput Screening System in Drosophila: an Opportunity to Understand Colonization. Maria Jaime, Carnegie Science
- Session Chair:
- Molly Schumer, Stanford University
305
11:00 am
Assembly of a young vertebrate Y chromosome reveals convergent signatures of sex chromosome evolution. Catherine Peichel, University of Bern
306
11:15 am
A supernumerary chromosome produces a 0W/00 sex determination system in a cichlid fish. Erin Peterson, NC State University
307
11:30 am
Odorant receptor tuning contributes to the evolution of sexual signaling in perfume-collecting orchid bees. Philipp Brand, Rockefeller University
308
11:45 am
The selective forces and genetic basis of mating interactions that contribute to the rapid evolution of reproductive isolation. Dean Castillo, University of Utah
309
12:00 pm
Repeated evolution of circadian clock dysregulation in cavefish populations. Katya Mack, Stanford University
310
12:15 pm
The genetics of reproductive isolation through host switching in experimentally evolved pigeon lice (Columbicola columbae). James Baldwin-Brown, University of Utah
- Session Chair:
- John Pringle, Stanford University
311
11:00 am
Towards a systematic map of the functional role of protein phosphorylation. Bede Busby, European Molecular Biology Laboratory
312
11:15 am
Species-wide survey of background-dependent phenotype across yeast natural populations. Jing Hou, University of Toronto
313
11:30 am
Gene regulatory network reconstruction using single-cell RNA sequencing of barcoded genotypes in diverse environments. David Gresham, New York University
314
11:45 am
Connecting novel rare disease gene discoveries to functional characterization research in yeast and other model organisms. Phil Hieter, University of British Columbia
315
12:00 pm
Introduction of Jonathan Weissman for the Ira Herskowitz Presentation. Orna Cohen-Fix, NIH/NIDDK
316
12:05 pm
Ira Herskowitz Award Presentation. Jonathan Weissman, University of California, San Francisco
- Session Chairs:
- Qing Deng, Purdue University
- George Eisenhoffer, MD Anderson Cancer Center
317
11:00 am
The recycling endosome protein Rab25 coordinates actomyosin network maintenance, mitosis and cytokinesis to regulate epithelial tissue spreading in the zebrafish gastrula. Morley Willoughby, University of Toronto
318
11:15 am
Dynamic actomyosin pulses induce visco-elastic heterogeneity to drive epithelial cell extrusion. Youmna Atieh, The University of Texas MD Anderson Cancer Center
319
11:30 am
Genetic analysis of ileal identity in the zebrafish intestine. Jia Wen, Duke University
320
11:45 am
Regulation of protrusive behavior during collective cell migration. Hannah Olson, Oregon Health and Science University
321
12:00 pm
Studying meningeal development and function using the zebrafish. Marina Venero Galanternik, National Institutes of Health
74
12:15 pm
E4bp4-2b/Nfil3-2b contributes to circadian regulation by repressing cryptochrome1aa and period2 expression via the D-box enhancer. Han Wang, Soochow University
- Session Chair:
- Richard Poole, University College London
322
1:30 pm
Homeobox gene encode neuronal cell type diversity. Oliver Hobert
323
2:00 pm
Embryo to mother signal to clean up molecular garbage-transgenerational proteostasis adjustment via exopher production. Sangeena Salam, Rutgers University
324
2:15 pm
Retrograde extension as a general mechanism of sensory dendrite development. Maxwell Heiman, Boston Children's Hospital
325
2:30 pm
FKH-7/FOXP regulates sensory neuron function during developmental decision-making. Cynthia Chai, California Institute of Technology
326
2:45 pm
Distinct mechanisms regulate presynaptic release of functionally similar insulin/IGF-like proteins in C. elegans sensory neurons. Tali Gidalevitz, Drexel University
327
3:00 pm
Sensory cilia as the Achilles heel of nematodes when attacked by carnivorous mushrooms. Yen-Ping Hsueh, Academia Sinica
- Session Chairs:
- Melissa Harrison, U Wisconsin
- Daniel McKay, UNC Chapel Hill
- Jeff Sekelsky, UNC Chapel Hill
- Astrid Haase, NIH/NIDDK
- Evan Dewey, UNC Chapel Hill
328
1:30 pm
Ecdysone Signaling Shapes Tissue Regeneration in Wing Discs through Regulation of Wingless Expression. Faith Karanja, University of Virginia
329
1:45 pm
The temporal transcription factor E93 controls enhancer competency during Drosophila wing development. Matthew Niederhuber, University of North Carolina
330
2:00 pm
The transcription factor M1BP targets CP190 to chromatin to regulate transcription and chromatin insulator activity. Indira Bag, NIH
331
2:15 pm
Coordinate regulation of salivary gland form and function by ribbon during tubulogenesis. Rajprasad Loganathan, Johns Hopkins University
332
2:30 pm
Ribosomal DNA-specific retrotransposons maintain unstable ribosomal DNA repeats in the Drosophila male germline. Jonathan Nelson, University of Michigan
333
2:45 pm
Targeted de novo centromere formation in Drosophila reveals plasticity and maintenance potential of CENP-A chromatin. Barbara Mellone, University of Connecticut
334
3:00 pm
Gazing into the CRISPR crystal ball – experimental and computational analysis of Cas9-induced alternative end-joining in Drosophila. Mitch McVey, Tufts University
- Session Chairs:
- Matt Sieber, UT Southwestern
- Savraj Grewal, University of Calgary
- Heidi Bretscher, University of Minnesota
335
1:30 pm
Adipose mitochondrial metabolism couples nutrients to systemic insulin signaling and growth. Shrivani Pirahas, University of Calgary
336
1:45 pm
Clu bliss particles respond to nutritional regulation in Drosophila germ cells. Kelsey Sheard, Uniformed Services University
337
2:00 pm
A rapidly evolving actin-related protein monitors sperm quality in Drosophila. Courtney Schroeder, Fred Hutchinson Cancer Research Center
338
2:15 pm
CDK-regulated phase separation seeded by histone genes ensures precise growth and function of Histone Locus Bodies. Robert Duronio, University of North Carolina
339
2:30 pm
Optogenetic dissection of signaling crosstalk in the early embryo. Sarah McFann, Princeton University
340
2:45 pm
Regulation of Mitochondrial Network Organization in Muscles. Prasanna Katti, National Institutes of Health
341
3:00 pm
A CSN-SDR-PLIN2 axis regulates lipid droplet size via affecting Brummer ATGL lipase. Xun Huang, IGDB, CAS
- Session Chair:
- Martin Hrabe de Angelis, Helmholtz Zentrum Munich GmbH
342
1:30 pm
Efficient and effective curriculum development and training for biological sciences. Sue McClatchy, The Jackson Laboratory
343
1:45 pm
The mouse Gene Expression Database (GXD): fostering insights into the molecular mechanisms of development and disease. Constance Smith, The Jackson Laboratory
344
2:00 pm
Completing the GENCODE gene catalogue for the mouse reference genome. Jane Loveland, EMBL-EBI
345
2:15 pm
Disease Portals at RGD: Access to Consolidated Disease-Related Data and Tools Across Species. Jennifer Smith, Medical College of Wisconsin
369
2:30 pm
Combined transient ablation and single cell RNA sequencing reveals the development of medullary thymic epithelial cells. Kristen Wells, Stanford University School of Medicine
2:45 pm
International Mammalian Genome Society Trainee Awards. Linda Siracusa, IMGS President
- Session Chair:
- Dmitri Petrov, Stanford University
346
1:30 pm
Announcement of the James F Crow Early Career Researcher Award . Bret Payseur
347
1:45 pm
Selection against archaic DNA in human regulatory regions. Kelley Harris, University of Washington
348
2:00 pm
Natural hybridization reveals incompatible alleles causing melanoma in swordtail fish. Molly Schumer, Stanford
349
2:15 pm
The role of local adaptation in shaping GxE. Emily Josephs, Michigan State University
350
2:30 pm
Evolution of the essential gap gene giant causes hybrid inviability in Drosophila. Daniel Matute, University of North Carolina, Chapel Hill
351
2:45 pm
The epistatic norm of reaction. Brandon Ogbunu, Brown University
367
3:00 pm
Chromatin and epigenomic variation reveals the gene regulatory landscape of adaptive divergence in sticklebacks. Felicity Jones, Friedrich Miescher Laboratory of Max Planck Society
- Session Chairs:
- Kerry Bloom, University of North Carolina, Chapel Hill
- Jodi Nunnari, University of California, Davis
352
1:30 pm
A non-canonical Hippo pathway regulates spindle disassembly and cytokinesis during meiosis II in Saccaromyces cerevisiae. Linda Huang, University Massachusetts Boston
353
1:45 pm
Measuring load-bearing interactions between the Dam1 complex and its multiple binding sites in the Ndc80 complex. Rachel Flores, University of Washington
354
2:00 pm
Spatial segregation of repair pathways within the pericentromere. Kerry Bloom, University of North Carolina at Chapel Hill
355
2:15 pm
Ubiquitin hydrolase regulation of membrane scission by ESCRT-III. Greg Odorizzi, University of Colorado
356
2:30 pm
Comprehensive protein architecture of the yeast epigenome at high resolution. Frank Pugh, Penn State University
357
2:45 pm
SGD Update. Mike Cherry, Stanford University
- Session Chairs:
- Charles Kaufman, Washington University School of Medicine
- Zhaoxia Sun, Yale University School of Medicine
358
1:30 pm
Enteroendocrine cells sense gut bacteria and activate a gut-brain pathway. Lihua Ye, Duke University
359
1:45 pm
A Novel Model of Retinal Ganglion Cell Death and Regeneration in Zebrafish. Kevin Emmerich, Johns Hopkins University School of Medicine
360
2:00 pm
Building the Vertebrate Codex using the Gene Breaking Protein Trap Library. Noriko Ichino, Mayo Clinic
361
2:15 pm
The Reissner Fiber is Highly Dynamic in vivo and Controls Morphogenesis of the Spine. Ryan Gray, Univeristy of Texas at Austin - Dell Medical School
362
2:30 pm
Analysis of craniosynostosis risk factors in zebrafish. Xuan He, Boston University
363
2:45 pm
NMDA receptor dependent nervous system functions. Howard Sirotkin, Stony Brook University
- Session Chair:
- Hugo Bellen, Baylor College of Medicine
The generation of neural diversity. Claude Desplan, New York University
Selective interference and the evolution of sex. Sarah Otto, University of British Columbia
Spatial patterning of meiotic recombination. Abby Dernburg, University of CA, Berkeley
Break