All Plenary & Platform Sessions Listing
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Wednesday, July 13 7:00 PM – 9:00 PM
Grand Ballroom 8A
Plenary Session 1: Germline Dynamics
| Co-Moderators: | Joshua Bembenek, University of TN, Knoxville, and Hannah Seidel, University of WI and Eastern Michigan University |
Theme: Stem Cell, Regeneration and Germline
W397 - 7:00 Domestication of C. elegans Sperm. Michael Miller.
W398 - 7:40 Visualization and quantification of the transcriptional response to GLP-1/Notch signaling in the germline stem cell niche. Judith Kimble.
W399 - 8:05 Dynein subunit DLC-1 promotes localization and function of stem cell regulator FBF-2 in C. elegans. Xiaobo Wang.
W400 - 8:30 After extrusion, the second polar body is internalized via receptor-mediated phagocytosis in C. elegans embryos. Ann Wehman.
Wednesday, July 13 7:00 PM – 9:00 PM
Palms Ballroom Canary 2
Ciliate Genomics: Genome Structure and Organization
| Moderator: | Laura Landweber, Princeton University, NJ and Columbia University, NY |
Theme: Genomics and Gene Regulation
C13 - 7:00 Maintenance and loss of duplicated genes by dosage subfunctionalization in Paramecium. Jean-Francois Pierre Gout.
C14 - 7:30 De-Novo sequencing of the Paramecium tetraurelia macronucleolar (MAC) genome using Pacific Biosciences single molecule long reads for improvement of genome assembly and annotation. Rafal Woycicki.
C15 - 7:45 Comparative genomics in the ciliate genus Paramecium. Georgi Marinov.
C16 - 8:00 Programmed retention of germline-limited genes in Oxytricha trifallax. Richard Miller.
C17 - 8:15 Cell Cycle Transcriptome Analysis in the Binucleated Ciliate, Tetrahymena thermophila. Linying Zhang.
C18 - 8:30 RNA-seq analysis of stress response to silver nanoparticles in Tetrahymena thermophila. Angela Piersanti.
C19 - 8:45 Preliminary analysis on genome and transcriptome data of two species of karyorelictids, Loxodes sp. and Trachelocercidae sp. (Ciliophora, Karyorelictea). Ying Yan.
Wednesday, July 13 7:00 PM – 9:00 PM
Palms Ballroom Royal
Opening General Session
| Moderator: | Susan Celniker, Lawrence Berkely National Laboratory, CA |
Presentations:
- 7:00 Welcome and Opening Remarks. 7:00 Welcome and Opening Remarks. Susan Celniker 7:10 Remembering Bill Gelbart. Thom Kaufman . Susan Celniker.
- 7:10 Remembering Bill Gelbart. Thom Kaufman.
D76 - 7:15 Image Award Presentation. Michelle Arbeitman.
D77 - 7:20 Presentation of Larry Sandler Award and Lecture. Daniella Drummond-Barbosa.
D78 - 7:25 Larry Sandler Award Winner.
D79 - 7:55 Discovery of the Homeobox Panel featuring Matthew Scott, Michael Levine and William McGinnis. Moderator Cassandra Extavour.
Wednesday, July 13 7:00 PM – 9:00 PM
Crystal Ballroom G1
International Resources
| Moderator: | Thomas Keane, Sanger Institute, Cambridge, UK |
Theme: New Technology and Resources
Presentations:
M251 - 7:00 Building the first comprehensive functional catalogue of a mammalian genome. Martin Hrabé de Angelis.
M252 - 7:15 Large-scale discovery of embryonic lethal phenotypes in mice. Stephen Murray.
M254 - 7:30 The DMDD programme: an online database of embryonic lethal mouse gene mutations. Jacqui White.
M255 - 7:45 GENCODE: using new technologies to improve reference mouse genome annotation. Mark Thomas.
M256 - 8:00 Trainee Talk.
M257 - 8:15 Trainee Talk.
M661 - 8:30 Trainee Talk.
M258 - 8:45 Beyond the spreadsheet. Kenneth Manly.
Wednesday, July 13 7:00 PM – 9:00 PM
Crystal Ballroom J1, K-L
PEQG Keynote 1
| Moderator: | Michael Lynch, Indiana University, Bloomington |
Theme: Evolution and Quantitative Biology
Presentations:
P315 - 7:00 Evolution of gene expression: from mutation to polymorphism to divergence. Patricia Wittkopp.
P316 - 7:30 The hidden complexity of Mendelian inheritance in natural populations. Joseph Schacherer.
P317 - 7:45 Parallel Gene Expression Differences between Low and High Latitude Populations of two Drosophila species. Li Zhao.
P318 - 8:00 Trans regulatory architecture of genetic transcriptome variation from 1,000 yeast individuals. Frank Albert.
P319 - 8:15 The genomic basis of environmental adaptation in house mice. Megan Phifer-Rixey.
P320 - 8:30 Parallel selective sweeps of selfish Segregation Distorter complexes in African and European Drosophila melanogaster populations. Amanda Larracuente.
P321 - 8:45 Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross. Ian Ehrenreich.
Wednesday, July 13 7:00 PM – 9:00 PM
Crystal Ballroom G2
Winge-Lindegren Address by Rodney Rothstein and The Dynamic Genome Scientific Session
| Moderator: | Gavin Sherlock, Stanford University, CA |
Theme: Genomics and Gene Regulation
Y463 - 7:00 Winge-Lindegren Address. Rodney Rothstein.
Y464 - 7:30 Using Experimental Evolution To Engineer A Low Flocculation Yeast Strain. Elyse Hope.
Y465 - 7:45 Ploidy tug-of-war: evolutionary and genetic environments influence the rate of ploidy drive in a human fungal pathogen. Meleah Hickman.
Y466 - 8:00 Mechanism of non-genetic heterogeneity in yeast growth rate and stress resistance. Shuang Li.
Y467 - 8:15 The concerted function of the Shu complex and the Rad51 paralogs in Rad51 presynaptic assembly. Kara Bernstein.
Y468 - 8:30 Genome-wide detection of genomic fluctuations in Saccharomyces cerevisiae. Kim Palacios Flores.
Wednesday, July 13 7:00 PM – 9:00 PM
Grand Ballroom 7A
Regeneration and Stem Cells
| Moderator: | Richard Dorsky, University of Utah |
Theme: Stem Cell, Regeneration and Germline
Z531 - 7:00 Modulation of tissue repair by regeneration enhancer elements. Junsu Kang.
Z532 - 7:15 A screen for epigenetic regulators reveals a requirement for Ing4 in HSC specification and function. Katie Kathrein.
Z533 - 7:30 Zebrafish T cells mediate organ-specific regenerative programs . Kazu Kikuchi.
Z534 - 7:45 Production of medaka individuals derived from cryopreserved spermatogonia by allogenic transplantation. Shinsuke Seki.
Z535 - 8:00 Zebrafish heart regeneration requires alleviation of cardiomyocyte genomic stress by BMP signaling. Gilbert Weidinger.
Z536 - 8:15 Autophagy Activation via FGF Signaling Regulates Cytoplasmic Remodeling of Regenerating Adult Zebrafish Myocytes. Alon Kahana.
- 8:30 Four and a Half LIM Domains 1b (Fhl1b) Is Essential for Regulating the Liver versus Pancreas Fate Decision and for beta-Cell Regeneration. Chong Shin.
Thursday, July 14 7:45 AM – 10:00 AM
Palms Ballroom Sago/Sabal/Royal
Genetics and Determinants of Health Joint Plenary Session
| Moderator: | Lynn Cooley, Yale University |
Presentations:
- 7:45 Welcome, Stan Fields, University of Washington, Seattle, GSA President.
- 7:50 Opening Remarks, Phil Hieter, University of British Columbia and Jeannie Lee, Harvard University, TAGC Organizers.
J1 - 8:00 Translating Zebrafish Development to the Clinic. Leonard Zon.
J2 - 8:30 Using Drosophila to unravel the mysteries of sleep: when, why and how. Amita Sehgal.
J3 - 9:00 New insights into the pathogenesis and treatment of Marfan syndrome and other presentations of thoracic aortic aneurysm. Harry Dietz.
J4 - 9:30 Accelerating Insights from Basic Genetics. Francis Collins.
Thursday, July 14 10:30 AM – 12:30 PM
Grand Ballroom 8A
Genomics, Gene Regulation and Technology
| Co-Moderators: | Harold Smith, NIH/NIDDK, Bethesda, MD, and Julie Ahringer, University of Cambridge, United Kingdom |
Theme: New Technology and Resources
W401 - 10:30 X-specific targeting of the C. elegans dosage compensation complex. Sevinc Ercan.
W402 - 10:45 Properties and activities of enhancers and promoters. Chiara Cerrato.
W403 - 11:00 Quantitative analysis of context-dependent regulation by the Wnt pathway at single cell resolution. John Murray.
W404 - 11:15 ShootingStar: Real-Time Tracking and Optical Manipulation of Single Cells in Development. Pavak Shah.
W405 - 11:30 Tissue-specific analysis of nuclear organization through development of a novel FLP/Frt-based toolkit for spatiotemporal control of gene expression. Peter Askjaer.
W406 - 11:45 Systematic engineering of a temperature-optimized Gal4/UAS system for transcriptional control of gene expression in Caenorhabditis elegans. Jonathan Liu.
W407 - 12:00 Longevity and its transgenerational inheritance is enabled by H3K9 methylation. Teresa Lee.
W408 - 12:15 CRISPR-mediated synthetic genetic analysis reveals genetic interactions among RNA binding proteins affecting fitness and lifespan. Adam Norris.
Thursday, July 14 10:30 AM – 12:30 PM
Palms Ballroom Canary 2
Programmed DNA Rearrangement I
| Co-Moderators: | Eric Meyer, IBENS, Paris, France, and Mireille Betemier, I2BC, Gif-sur-Yvette, France |
Theme: Stem Cell, Regeneration and Germline
C20 - 10:30 Genome Rearrangement and Organization in Oxytricha: A Complex Epigenome. Laura Landweber.
C21 - 11:00 Novel genetic manipulation approaches to investigate development-specific genes in Oxytricha trifallax. Derek Clay.
C22 - 11:15 The prevalence of paralogous macronuclear DNA fragments aid in the formation of scrambled genes in Oxytricha trifallax. Jonathan Burns.
C23 - 11:30 Domesticated piggyBac transposases and DNA repair factors work hand in hand during programmed rearrangements in Paramecium. Mireille Betermier.
C24 - 12:00 SDCP, a novel Paramecium protein involved in macronuclear development during autogamy. Aditi Singh.
C25 - 12:15 A mutagenesis screen based on mating-type switch reveals a small subset of IESs enriched in a 5-bp motif. Simran Bhullar.
Thursday, July 14 10:30 AM – 12:30 PM
Palms Ballroom Sago/Sabal/Royal
Drosophila Plenary Session I
| Moderator: | David Bilder, University of California, Berkeley |
Presentations:
D80 - 10:30 Organizing the contraction that changes tissue shape. Adam Martin.
D81 - 11:00 Hox Transcription Factors and their Cell type-specific Role in Development. Ingrid Lohmann.
D82 - 11:30 Modelling Intellectual Disability Disorders in Drosophila - from Genes to Functional Modules and Clinical Applications. Annette Schenck.
D83 - 12:00 Hippo Signaling in Growth Control and Beyond. Doujia Pan.
Thursday, July 14 10:30 AM – 12:30 PM
Crystal Ballroom G1
Comparative Genomics, Computational Methods and Evolution
| Co-Moderators: | Steve Munger, Jackson Laboratory, Bar Harbor, ME, and Clement Chow, The University of Utah, Salt Lake City |
Theme: Evolution and Quantitative Biology
Presentations:
M259 - 10:30 Good dad, bad dad: the genetic basis of parental care Hopi Hoekstra.
M260 - 11:00 Accumulation and detection of germline spontaneous mutations in C57BL/6JJcl inbred mouse strain. Yoichi Gondo.
M261 - 11:15 Discovery, assembly, and annotation of subspecies specific haplotypes in classical and wild-derived mouse strains. Jingtao Li.
M262 - 11:30 Post-translational mechanisms buffer protein abundance against transcriptional variation. Gary Churchill.
M263 - 11:45 Trainee Talk.
M264 - 12:00 Trainee Talk.
M265 - 12:15 Multiple mouse reference genomes defines subspecies specific haplotypes and novel coding sequences. Thomas Keane.
Thursday, July 14 10:30 AM – 12:30 PM
Crystal Ballroom J1, K-L
Natural Selection and Adaptation
| Moderator: | Dmitri Petrov, Stanford University, CA |
Theme: Evolution and Quantitative Biology
Presentations:
P322 - 10:30 Genome-wide selection component analysis in a wild pedigreed population of the Florida Scrub-Jay. Andrew Clark.
P323 - 10:45 Drosophila melanogaster-specific genes rapidly evolved strong fitness effects. Nicholas VanKuren.
P324 - 11:00 Examining the effects of natural selection on linked neutral divergence. Tanya Phung.
P325 - 11:15 Genome-wide signals of adaptation in mammals and the arms race with viruses. David Enard.
P326 - 11:30 Evolution of gene expression in giant island mice. Mark Nolte.
P327 - 11:45 Does the Y-chromosome facilitate sexual dimorphic evolution or constrain autosomal evolution? Ian Kutch.
P328 - 12:00 The antibiotic-independent evolution of antibiotic resistance. Ruth Hershberg.
P329 - 12:15 Dynamics and feasibility of CRISPR/Cas9-mediated gene drives in natural populations. Philipp Messer.
Thursday, July 14 10:30 AM – 12:30 PM
Crystal Ballroom G2
Post-Transcriptional Gene Regulation
| Moderator: | Audrey Gasch, University of WI, Madison |
Theme: Genomics and Gene Regulation
Y469 - 10:30 A cradle-to-grave analysis of cis-regulatory variation in yeast. Jennifer Andrie.
Y470 - 10:45 Msn2 regulates cellular response and growth to stress through modulation of its localization and DNA binding. Vasudha Bharatula.
Y471 - 11:00 Stress-dependent transcriptome changes serve to reallocate translational capacity during stress acclimation. Yi-Hsuan Ho.
Y472 - 11:15 Genetic factors controlling accelerated mRNA degradation during a nitrogen upshift. Darach Miller.
Y473 - 11:30 P bodies regulate the rewiring of a transcription network by controlling the expression of the YOX1 repressor during DNA replication stress. Raphael Loll-Krippleber.
Y474 - 11:45 Gene control by prion-like conformations of intrinsically disordered proteins. Daniel Jarosz.
Y475 - 12:00 Parallel pathways for export of tRNAs from the nucleus to the cytoplasm. Anita Hopper.
Y476 - 12:15 Yeast telomerase and RNase P/MRP: when two different worlds come together. Nancy Laterreur.
Thursday, July 14 10:30 AM – 12:30 PM
Grand Ballroom 7A
Early Development and Morphogenesis
| Moderator: | Ashley Bruce, University of Toronto, Canada |
Theme: Development and Morphogenesis
Z539 - 10:30 A Meiotic-Vegetal Center Couples Oocyte Polarization with Meiosis. Yaniv Elkouby.
Z540 - 10:45 Investigating the function of the yolk cell microtubules during zebrafish epiboly. Ashley Bruce.
Z541 - 11:00 Myo1D, an unconventional myosin regulates kupffer’s vesicle lumenogenesis in zebrafish. Manush Saydmohammed.
Z542 - 11:15 Combinatorial signaling interactions pattern the dorsal-ventral mesodermal axis by controlling bHLH transcription factor activity. Benjamin Martin.
Z543 - 11:30 Functional conservation of the zebrafish germ plasm organizer Bucky ball and Drosophila Oskar. Pritesh Krishnakumar.
Z544 - 11:45 Fibroblast growth factor 24 is required for early somatic gonad development in zebrafish. Dena Leerberg.
Z545 - 12:00 Wnt signaling regulates progenitor cell identity and collective cell migration in the lateral line. Hillary McGraw.
Z546 - 12:15 Migratory neural crest is required for patterning and morphogenesis of the embryonic optic cup. Chase Bryan.
Thursday, July 14 10:30 AM – 12:30 PM
Grand Ballroom 7B
Neural Circuits, Neurophysiology and Behavior
| Moderator: | Alex Schier, Harvard University, MA |
Theme: Neuroscience, Systems to Molecules
Z547 - 10:30 Neuronal connectivity analysis of wild-type and mutant zebrafish with transsynaptic virus and 3D brain mapping. Manxiu Ma.
Z548 - 10:45 Assembling the MET complex in sensory hair cells: Tomt regulates the trafficking of Tmc proteins to the site of mechanotransduction. Timothy Erickson.
Z549 - 11:00 Asymmetric activation of the dorsal habenulae correlates with larval recovery from electric shock. Erik Duboué.
Z550 - 11:15 Linking function to cell type in the optic flow responsive circuit in zebrafish larva. Anna Kramer.
Z551 - 11:30 A forward genetic screen identifies the G-protein coupled calcium receptor CaSR as a regulator of simple decision-making. Roshan Jain.
Z552 - 11:45 Feeding state modulates behavioral choice and processing of prey stimuli in the zebrafish tectum. Alessandro Filosa.
Z553 - 12:00 Impact of circadian protein Period2 on glucocorticoid signaling and depression regulation. Mingyong Wang.
Z554 - 12:15 Visualizing Inhibitory Structural Synaptic Plasticity During Day and Night. Idan Elbaz.
Thursday, July 14 4:00 PM – 6:00 PM
Grand Ballroom 8A
Intracellular Organelles, Trafficking, and the Cytoskeleton
| Co-Moderators: | Anne Spang, University of Basel, Switzerland, and Martin Srayko, University of Alberta, Canada |
Theme: Intracellular Dynamics
W409 - 4:00 Investigating the role of microtubule minus-end proteins in noncentrosomal microtubule organization during epithelial development. Taylor Skokan.
W410 - 4:15 Cytoskeletal elements function together to move larval P-cell nuclei through constricted spaces. Courtney Bone.
W411 - 4:30 Mitochondria localize to injured axons to support regeneration. Sungmin Han.
W412 - 4:45 C.elegans as a model to study extracellular vesicle biology, dynamics and function. Jyothi Akella.
W413 - 5:00 The TspanC8 tetraspanins TSP-12 and TSP-14 function through the ADAM10 protease SUP-17 to promote BMP signaling in C. elegans. Lin Wang.
W414 - 5:15 Conserved NEKL/MLT protein network controls molting in C. elegans. Vladimir Lazetic.
W415 - 5:30 The catalytic activity of twitchin’s kinase domain inhibits muscle activity. Guy Benian.
W416 - 5:45 Modeling cerebral cavernous malformations in C. elegans. Brent Derry.
Thursday, July 14 4:00 PM – 6:00 PM
Palms Ballroom Canary 2
Evolution and Population Biology
| Moderator: | Jean-Francois Gout, Indiana University, Bloomington |
Theme: Evolution and Quantitative Biology
C26 - 4:00 Transposable elements as vehicles of gene movement and duplication within and between eukaryotes. Ellen Pritham.
C27 - 4:30 Evolution of internal eliminated sequences in Paramecium. Diamantis Sellis.
C28 - 4:45 Population genomics of Paramecium species. Parul Johri.
C29 - 5:00 Transcriptome analysis in the Antarctic ciliate Euplotes focardii: molecular basis of cold adaptation and insights regarding the potential impact of climate change. Cristina Miceli.
C30 - 5:30 Comparison of adaptive mechanism between sexual and asexual reproduction in Tetrahymena thermophila based on the experimental evolutionary genomics. Wei Miao.
C31 - 5:45 Diversities of endosymbiotic Rickettsia in the fish parasite Ichthyophthirius multifiliis. Kassandra Zaila.
Thursday, July 14 4:00 PM – 6:00 PM
Palms Ballroom Sago
Cell Division and Growth Control
| Co-Moderators: | Erika Bach, New York University , and Terry Orr-Weaver, Whitehead Inst, MIT, and Kari Barla, University of Chicago |
Theme: Intracellular Dynamics
D84 - 4:00 Centrosomes and the Spindle Assembly Checkpoint cooperatively ensure proper growth and organization of the developing fly brain by promoting genome stability and viability of neural stem cells. John Poulton.
D85 - 4:15 The GATOR2 Complex Uses TORC1 Dependent and Independent Pathways to Regulate Cellular Metabolism. Mary Lilly.
D86 - 4:30 Vamana couples Fat signaling to the Hippo pathway. Jyoti Misra.
D87 - 4:45 Genetic regulation of cell-fate plasticity in Drosophila imaginal discs. Melanie Worley.
D88 - 5:00 Oxidative Stress in Oocytes During Mid-Prophase Induces Premature Loss of Cohesion and Chromosome Segregation Errors. Adrienne Perkins.
D89 - 5:15 Yorkie, a transcriptional co-activator that regulates growth, also functions at the cell cortex to promote cytoskeletal tension. Jiajie Xu.
D90 - 5:30 Notch signaling promotes cell proliferation and controls cell identity in developing imaginal ring cells. Sheng-An Yang.
D91 - 5:45 Regulating the regulator of cell cycle, Xpd. RISHITA NAG.
Thursday, July 14 4:00 PM – 6:00 PM
Palms Ballroom Sabal
Neural Development
| Co-Moderators: | Ron Davis, The Scripps Research Inst, and Krystyna Keleman, HHMI Janelia Research Campus, and Yang Wu, HHMI Janelia Research Campus |
Theme: Neuroscience, Systems to Molecules
D92 - 4:00 Formin3 regulates dendritic architecture via microtubule stabilization and is required for somatosensory nociceptive behavior. Ravi Das.
D93 - 4:15 Heparan sulfate proteoglycans promote dendritic growth of Drosophila sensory neurons through receptor protein tyrosine phosphatase Ptp69D. Amy Poe.
D94 - 4:30 nejire-mediated transcriptional regulation of dendritic growth and arborization complexity. Sarah Clark.
D95 - 4:45 A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity. Scott Barish.
D96 - 5:00 Developmental programs and olfactory receptor signaling in structural and functional development of fruitless positive olfactory neurons. PELIN VOLKAN.
D97 - 5:15 Inhibition of mitochondrial calcium entry in mushroom body neurons during pupariation causes memory impairment and neuronal structural defects in adult flies. Ilaria Drago.
D98 - 5:30 Syncrip regulates prospero stability during neuroblasts division and differentiation. Lu Yang.
D99 - 5:45 Spontaneous grooming and other activity phenotypes resulting from Neurofibromin loss of function in Drosophila. Lanikea King.
Thursday, July 14 4:00 PM – 6:00 PM
Palms Ballroom Royal
Organogenesis and Gametogenesis
| Co-Moderators: | Mark Van Doren, Johns Hopkins University, and Erika Matunis, Johns Hopkins Medicine, and Pradeep Bhaskar, Johns Hopkins University |
Theme: Stem Cell, Regeneration and Germline
D100 - 4:00 Mediator subunit skuld is required sex specifically for ovary development. Hina Sultana.
D101 - 4:15 Neuropeptide-dependent control of female germline stem cell proliferation after mating in Drosophila melanogaster. Tomotsune Ameku.
D102 - 4:30 Electron Transport Chain Remodeling by GSK3 during Oogenesis Connects Nutrient State to Reproduction. Matt Sieber.
D103 - 4:45 The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication. Yi Zhang.
D104 - 5:00 Signaling through the G-protein-coupled receptor Rickets is important for polarity, detachment, and migration of the border cells in Drosophila. LAUREN ANLLO.
D105 - 5:15 A mutation in fat2 uncouples tissue elongation from global tissue rotation in Drosophila. Franziska Aurich.
D106 - 5:30 Steroid signaling in mature follicles is essential for Drosophila ovulation. Elizabeth Knapp.
D107 - 5:45 Identification and characterization of an “insect epididymis”. Timothy Karr.
Thursday, July 14 4:00 PM – 6:00 PM
Crystal Ballroom G1
Development
| Moderator: | Bill Pavan, NIH, Bethesda, MD |
Theme: Development and Morphogenesis
M266 - 4:00 Symmetry breaking and self-organization in mouse development. Takashi Hiiragi.
M267 - 4:30 A SUMO-Ubiquitin Relay Recruits Proteasomes to Chromosome Axes to Regulate Meiotic Recombination. Neil Hunter.
M268 - 4:45 SMC5/6 complex is required for the formation of bivalent chromosomes capable of segregation during meiosis I in oocytes. Grace Hwang.
M269 - 5:00 Imaging how Transcription Factors Bind DNA to Control Cell Fate in Living Mouse Embryos. Nicolas Plachta.
M270 - 5:15 Maternally provided KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally. Jadiel Wasson.
M271 - 5:30 A Forward Genetics Approach to Discover Modifiers of Developmental Phenotypes. Krista Geister.
M272 - 5:45 ER stress-induced remodeling of placental mRNA and small RNA expression networks. Clement Chow.
Thursday, July 14 4:00 PM – 6:00 PM
Crystal Ballroom J1
James F. Crow Symposium
| Moderator: | Bret Payseur, University of Wisconsin |
Theme: Evolution and Quantitative Biology
- 4:00 Introduction. Bret Payseur.
P330 - 4:15 Legacy of James Crow. Daniel Hartl.
P331 - 4:30 Estimating Jacquard's general model of relatedness from population genomic data. Matthew S. Ackerman.
P332 - 4:45 Dynamics of seasonal adaptation in Drosophila melanogaster. Emily Behrman.
P333 - 5:00 The fragile Y hypothesis: The role of Y aneuploidy in the evolution of sex chromosomes and genome architecture. Heath Blackmon.
P334 - 5:15 Using network theory to infer and analyze population structure from genetic data. Gili Greenbaum.
P335 - 5:30 Molecular variation across populations of a widespread North American firefly reveals selection on luciferase but not opsins. Sarah Sander.
P336 - 5:45 Fitness pleiotropy and the phenotypic basis of adaptation in experimentally evolving yeast. Sandeep Venkataram.
Thursday, July 14 4:00 PM – 6:00 PM
Crystal Ballroom G2
Epigenetics and Transcriptional Regulation
| Moderator: | Lorraine Pillus, University of CA, San Diego |
Theme: Genomics and Gene Regulation
Y477 - 4:00 Coordinated regulation of heterochromatin inheritance by Daf1/Dpb4 complex. Fei Li.
Y478 - 4:15 The Replication Kinase Cdc7 Marks Histones to Regulate Biosynthesis Genes. Patrick Grant.
Y479 - 4:30 An oncometabolite disrupts epigenetic processes and increases gene silencing in Saccharomyces cerevisiae. Ryan Janke.
Y480 - 4:45 Mechanistic insight into the role of the Paf1 complex in histone modification. S. Branden Van Oss.
Y481 - 5:00 Protein abundance control by non-coding antisense transcription. Florian Huber.
Y482 - 5:15 Promoter scanning during transcription initiation in Saccharomyces cerevisiae: Pol II in the “shooting gallery”. Craig Kaplan.
Thursday, July 14 4:00 PM – 6:00 PM
Grand Ballroom 7A
Cardiac Development
| Moderator: | Deborah Yelon, University of CA, San Diego |
Theme: Development and Morphogenesis
Z555 - 4:00 Identifying novel regulators of early cardiac development in zebrafish using single-cell mRNA-seq and ATAC-seq. Xuefei Yuan.
Z556 - 4:15 PDGF signaling directs cardiomyocyte movement toward the midline during heart tube assembly. Deborah Yelon.
Z557 - 4:30 Convergence of FGF and Nodal signals on the actin cytoskeleton controls cardiac cell migration in zebrafish. Meagan Grant.
Z558 - 4:45 Cardiomyocyte fusion in zabrafish. Suphansa Sawamiphak.
Z559 - 5:00 HDAC1 repression of retinoic acid-responsive genes promotes second heart field development. Yuntao Charlie Song.
Z560 - 5:15 Epigenetic control of zebrafish cardiogenesis by TET2/3. Yahui Lan.
Z561 - 5:30 Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium. Matthew Foglia.
Z562 - 5:45 Spatiotemporal regulation of cell size and nuclear content during regeneration of the epicardium. Jingli Cao.
Thursday, July 14 4:00 PM – 6:00 PM
Grand Ballroom 7B
Gene Regulation and RNA Biology
| Moderator: | Joan Heath, Walter and Eliza Hall Institute of Medical Research, Australia |
Theme: Genomics and Gene Regulation
Z563 - 4:00 The zebrafish embryo mRNA interactome reveals distinct roles for hnRNP A1 during the maternal to zygotic transition. Karla Neugebauer.
Z564 - 4:15 Clearance of maternal mRNAs via 3′-end uridylation in vertebrate embryos. Hyeshik Chang.
Z565 - 4:30 Testing the in vivo consequences of splicing and transcriptional crosstalk. Adriana De La Garza.
Z566 - 4:45 Longterm Regulation of Zebrafish Behavior by Maternal Rest/NRSF is Mediated by snap25a/b. Howard Sirotkin.
Z567 - 5:00 TFAP2A drives melanocyte gene expression in parallel with MITF. Hannah Seberg.
Z568 - 5:15 Tet-mediated DNA hydroxymethylation is required for retinal neurogenesis. Pawat Seritrakul.
Z569 - 5:30 Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells. Colin Lickwar.
Z570 - 5:45 Constructing gene regulatory networks underlying fate specification of multipotent progenitors in the zebrafish neural crest. Kleio Petratou.
Thursday, July 14 7:45 PM – 9:45 PM
Grand Ballroom 8A
Plenary Session 2: Systems Biology
| Co-Moderators: | Esther Zanin, The Ludgwig-Maximilians University of Munich, Germany, and Jun Takayama, RIKEN, Kobe, Japan |
Theme: Genomics and Gene Regulation
Presentations:
W417 - 7:45 A regulatory map of the C.elegans nervous system. Oliver Hobert.
W418 - 8:25 Single-cell C. elegans transcriptomics: Deciphering the expression of all genes in all cells throughout development. Itai Yanai.
W419 - 8:50 A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Mike Boxem.
W420 - 9:15 Caenorhabditis Genetics Center (CGC). Aric Daul.
Thursday, July 14 7:45 PM – 9:45 PM
Palms Ballroom Canary 2
Genome Stability and Dynamics
| Co-Moderators: | Jeff Kapler, Texas A&M University, College Station, and Josh Smith, Missouri State University, Springfield |
Theme: Genomics and Gene Regulation
C32 - 7:45 Genetic and epigenetic control of DNA replication in Tetrahymena thermophila. Geoffrey Kapler.
C33 - 8:15 Beyond condensation: novel roles for condensin in the polyploid somatic nucleus of Tetrahymena thermophila. Rachel Howard-Till.
C34 - 8:45 Repair of a fragile site in the mating type genes using an episomal template in Tetrahymena. Marcella Cervantes.
C35 - 9:00 Identification and Characterization of Tetrahymena thermophila Snf2/Swi2 ATPase Homologs involved in DNA Repair. Andrew Morin.
C36 - 9:30 Interplay between the Homologs Rad51 and Dmc1 in Cell Division, Sexual Reproduction, and Homologous Recombination Repair. Amaal Abulibdeh.
Thursday, July 14 7:45 PM – 9:45 PM
Palms Ballroom Sago
Cell Cycle and Cell Death
| Co-Moderators: | Arash Bashirullah, Univ. of Wisconsin- Madison, and Sarah Siegrist, University of Virginia, and Conor Sipe, University of Virginia |
Theme: Intracellular Dynamics
D108 - 7:45 An autonomous requirement of the lysosomal nuclease DNaseII in a caspase-independent primordial germ cell death in the Drosophila embryo. Lama Tarayrah.
D109 - 8:00 Move or Die: Linking caspases and cell migration and invasion in Drosophila. Eli Arama.
D110 - 8:15 Lysosome activity controls nurse cell death non-autonomously. Albert Mondragon.
D111 - 8:30 Programmed necrosis control germ cell homeostasis during Drosophila spermatogenesis. Bertrand Mollereau.
D112 - 8:45 Regulation of cell size by variant cell cycles. Terry Orr-Weaver.
D113 - 9:00 An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways. Hatem Elif Kamber Kaya.
D114 - 9:15 The Drosophila TNF Eiger activates Dronc-dependent necrosis when apoptosis is blocked. Mingli Li.
D115 - 9:30 Enhancer of Polycomb represses transcription of Cyclin B during male germ cell differentiation. Lijuan Feng.
Thursday, July 14 7:45 PM – 9:45 PM
Palms Ballroom Sabal
Evolution and Quantitative Genetics I
| Co-Moderators: | Marta Wayne, University of Florida, and Anthony Long, Univ. of California, Irvine, and Sharon Greenblum, Stanford University |
Theme: Evolution and Quantitative Biology
D116 - 7:45 Towards a Genetic Understanding of Behavior Evolution: An Ion-channel Gene Causes Natural Courtship Song Variation in Drosophila. Yun Ding.
D117 - 8:00 A delicate balance of mating preference in Drosophila melanogaster. Akihiko Yamamoto.
D118 - 8:15 Mechanism of hybrid incompatibility between two subspecies of Drosophila pseudoobscura. Christopher Large.
D119 - 8:30 Recurrent changes to pdm3 drive convergent evolution of female-limited polymorphism in the Drosophila montium subgroup. Emily Delaney.
D120 - 8:45 Evolution of the Sex Peptide Network: Lineage-specific adaptive evolution and gene duplication. Meaghan McGeary.
D121 - 9:00 Investigating the female’s role in sperm competition in Drosophila melanogaster. Simone White.
D122 - 9:15 Missing variation revealed by deep sequencing of individuals in a population of D. simulans. Sarah Signor.
D123 - 9:30 Mutational patterns in Drosophila melanogaster. Zoe June Assaf.
Thursday, July 14 7:45 PM – 9:45 PM
Palms Ballroom Royal
Pattern Formation
| Co-Moderators: | Ana Busturia, Centro de Biología Molecular Severo Ochoa, and Liz Gavis, Princeton University, and Mo Weng, Princeton University |
Theme: Development and Morphogenesis
D124 - 7:45 Cell fate transformations in sine oculis eye-specific LOF mutants obscures direct regulatory interactions within the retinal determination network. Bonnie Weasner.
D125 - 8:00 Genome-wide analyses of Hox target genes in Drosophila melanogaster. Narendra Singh.
D126 - 8:15 Manipulating fate with light – an optogenetics tool to understand Bcd function. Anqi Huang.
D127 - 8:30 Regulation of Dpp signaling by O-linked glycosylation. Matthew Moulton.
D128 - 8:45 A Transcription Factor code controlling serial specification of muscle identities in Drosophila . Alain Vincent.
D129 - 9:00 Tracking morphogens down: Uncovering the Dpp morphogen gradient. Pablo Sánchez Bosch.
D130 - 9:15 Flies have 11 abdominal segments (as suggested by the bithorax complex). Welcome Bender.
D131 - 9:30 Spatial patterning of the Drosophila ventral epithelium is important for proper tissue shape. Natalie Heer.
Thursday, July 14 7:45 PM – 9:45 PM
Crystal Ballroom G1
Translational and Systems Genetics
| Moderator: | Fernando Pardo Manuel de Villena, UNC, Chapel Hill, NC |
Theme: Neuroscience, Systems to Molecules
M273 - 7:45 Verne Chapman Lecture: Mendel 2.0, revisiting the determinants of inheritance and the origins of phenotypic variation. Joseph Nadeau.
M274 - 8:45 A suppressor screen in Mecp2 mice reveals pathways for Rett syndrome pathogenesis. Monica Justice.
M275 - 9:00 Systems Genetics Approach toward Understanding Regulation of MECP2 Expression in the Brain. Lucy Williams.
M276 - 9:15 Conserved and tissue-specific effects of natural genetic variation on transcript and protein abundance. Steven Munger.
M277 - 9:30 Discovering novel susceptibility genes for aggressive prostate cancer using an integrated, systems-based cross-species strategy. Jean Winter.
Thursday, July 14 7:45 PM – 9:45 PM
Crystal Ballroom J1, K-L
PEQG Keynote 2
| Moderator: | Lauren McIntyre, University of Florida, Gainesville |
Theme: Evolution and Quantitative Biology
P337 - 7:45 Systems genetics for industry: combining QTL mapping, GWAS and RNA sequencing to improve bone strength in laying hens. Dirk Jan de Koning.
P338 - 8:15 Effect of Genetic Architecture and Sample Size on the Accuracy of Genomic Prediction of Complex Traits. Fabio Morgante.
P339 - 8:30 A Powerful Yeast Mapping Panel for Complex Trait Genetics. Daniel Skelly.
P340 - 8:45 Using haplotype-based models for genomic predictions in crossbred animals and multiple breeds. Jared Decker.
P341 - 9:00 Dissection of complex traits in sorghum for the sustainable production of fuels and chemicals. Wilfred Vermerris.
P342 - 9:15 Rediscovering the Diallel: How inbred and F1 data can be used to define, model and estimate heritability of both ordinary and treatment-response traits. William Valdar.
P343 - 9:30 A New Trait Mapping Method for Drosophila Reveals Oligogenic Adaptation from Standing Genetic Variation. John Pool.
Thursday, July 14 7:45 PM – 9:45 PM
Crystal Ballroom G2
Lee Hartwell Lecture: Susan Gasser and Scientific Session: Tackling Human Disease Using Yeast
| Moderator: | Kara Dolinski, Princeton University, NJ |
Theme: Neuroscience, Systems to Molecules
Y483 - 7:45 Lee Hartwell Lecture. From Yeast to Worms and Beyond: Folding Dynamic Chromatin. Susan Gasser.
Y484 - 8:15 Pathway transplantation into yeast as a model for human disease. Neta Agmon.
Y485 - 8:30 Genetic and environmental backgrounds constrain the course of evolutionary rescue by compensatory mutations. Véronique Hamel.
Y486 - 8:45 The genomic repercussions of RAD5 overexpression. Robert Reid.
Y487 - 9:00 Functional characterization of human gene alleles using inter-species genetic approaches. Quan Zhong.
Y488 - 9:15 Genome-Wide Analysis in Yeast to Identify Molecular Targets Promoting Readthrough. Mert Icyuz.
Y489 - 9:30 Systematic functional analysis of resistance-conferring mutations. Lai Wong.
Thursday, July 14 7:45 PM – 9:45 PM
Grand Ballroom 7A
Neurobiology
| Moderator: | Teresa Nicolson, Oregon Health and Science University, OR |
Theme: Neuroscience, Systems to Molecules
Z571 - 7:45 Emergence of Patterned Activity in the Developing Zebrafish Spinal Cord. Yinan Wan.
Z572 - 8:00 Automated 3D cellular-resolution phenotyping of whole zebrafish with in situ RNA probe libraries. Yuelong Wu.
Z573 - 8:15 A conserved role for Lef1-mediated Wnt signaling in hypothalamic neurogenesis and anxiety. Yuanyuan Xie.
Z574 - 8:30 Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish. Mayssa Mokalled.
Z575 - 8:45 Light-dependent regulation of sleep/wake states by prokineticin 2 in zebrafish. David Prober.
Z576 - 9:00 A forward genetic screen identifies Huntingtin-interacting protein 14 as an in vivo regulator of zebrafish habituation learning. Jessica Nelson.
Z577 - 9:15 Larval zebrafish show individual left/right bias in movement direction during local light-search behavior. Eric Horstick.
Z578 - 9:30 Neuro-taxonomy: Towards a complete parts list of the zebrafish central nervous system. Herwig Baier.
Friday, July 15 8:00 AM – 9:30 AM
Grand Ballroom 8A
Aging and Cell Death
| Co-Moderators: | Javier Apfeld, Northeastern University, Boston, MA, and Jane Hubbard, New York University School of Medicine |
Theme: Disease Models and Aging
W421 - 8:00 Genetic Background and Experimental Reproducibility Play Critical Roles in Identifying Chemical Compounds with Robust Positive Effects on Longevity. Mark Lucanic.
W422 - 8:15 The neuroendocrine peptide DAF-7/TGF-β is a key regulator of dietary restriction in C. elegans. Marissa Fletcher.
W423 - 8:30 dbl-1/TGF-β and daf-12/NHR signaling mediate cell-nonautonomous effects of daf-16/FOXO on starvation-induced developmental arrest. Rebecca Kaplan.
W424 - 8:45 Fasting protects against proteostasis defects induced by hypoxia. Nicole Iranon.
W425 - 9:00 Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans. Sean Curran.
W426 - 9:15 RAB-35 coordinates the engulfment and degradation of apoptotic cell corpses. Ryan Haley.
Friday, July 15 8:00 AM – 9:30 AM
Palms Ballroom Canary 2
Programmed DNA Rearrangement II
| Moderator: | Mariusz Nowacki, University of Bern, Switzerland |
Theme: Stem Cell, Regeneration and Germline
C37 - 8:00 Both maternal and paternal scnRNAs can target excision of transposon-derived sequences during Paramecium development. Eric Meyer.
C38 - 8:30 Analysis of development-specific Piwi proteins in Paramecium. Dominique Furrer.
C39 - 8:45 Regulation of DNA elimination boundaries requires novel DNA-binding proteins that define heterochromatin domains. Douglas Chalker.
C40 - 9:15 Transiently maintained somatic chromosomes of Tetrahymena contain development-specific genes. Yifan Liu.
Friday, July 15 8:00 AM – 9:30 AM
Palms Ballroom Sago
Cell Biology and Cytoskeleton
| Co-Moderators: | Nasser Rusan, National Institutes of Health, and Rodrigo Fernandez-Gonzalez, Univ. of Toronto, and Todd Schoborg , National Heart, Lung, and Blood Institute, NIH |
Theme: Intracellular Dynamics
D132 - 8:00 An actomyosin-Arf-GEF negative feedback loop for tissue plasticity. Junior West.
D133 - 8:15 E-Cadherin decrease transmits proliferative-dependent forces via actin-myosin flows. Diana Pinheiro.
D134 - 8:30 A gradient of Rac activity determines protrusion form and position in a 3-dimensional epithelial sheet. Marios Georgiou.
D135 - 8:45 A STRIPAK-like complex regulates axonal transport of autophagosomes and dense core vesicles by modulating PP2A activity. Amanda Neisch.
D136 - 9:00 Centrosomal proteins are required for autophagy to maintain neural homeostasis. Yiming Zheng.
D137 - 9:15 Centrosome-pole cohesion requires Abnormal Spindle and Calmodulin to ensure proper centrosome inheritance in neural stem cells but is dispensable for brain size. Todd Schoborg.
Friday, July 15 8:00 AM – 9:30 AM
Palms Ballroom Sabal
Evolution and Quantitative Genetics II
| Co-Moderators: | Marta Wayne, University of Florida, and Anthony Long, Univ. of California, Irvine, and Sharon Greenblum, Stanford University |
Theme: Evolution and Quantitative Biology
D138 - 8:00 Local Adaptation and the Establishment of Inversions in Natural Populations of Drosophila pseudoobscura Through the Indirect Effects of Suppressed Recombination. Zach Fuller.
D139 - 8:15 Cis-regulatory basis of expression divergence between recent gene duplicates. Kohtaro Tanaka.
D140 - 8:30 Beyond the tip of the iceberg: New Drosophila reference genomes reveal novel structural variants. Mahul Chakraborty.
D141 - 8:45 Functional and evolutionary consequences of epigenetically silenced transposable elements in euchromatin. Grace Lee.
D142 - 9:00 Co-evolution within the nuclear branch of the Drosophila piRNA pathway. Swapnil Parhad.
D143 - 9:15 Lineage-specific rapid gains of satellite DNA in Drosophila. Kevin Wei.
Friday, July 15 8:00 AM – 9:30 AM
Palms Ballroom Royal
Chromatin and Epigenetics
| Co-Moderators: | Gary Karpen, Lawrence Berkeley Natl. Laboratory, and Amanda Larracuente, Univ. of Rochester, and Aniek Janssen, lbnl |
Theme: Genomics and Gene Regulation
D144 - 8:00 Repetitious elements drive silencing in the Drosophila melanogaster genome through heterochromatin formation. Sarah Elgin.
D145 - 8:15 Establishment and maintenance of heritable patterns of chromatin structure during early embryogenesis. Shelby Blythe.
D146 - 8:30 Deciphering double strand break repair in heterochromatin and euchromatin using an in vivo Drosophila model. Aniek Janssen.
D147 - 8:45 The Drosophila Y chromosome acts as a heterochromatin sink and contributes to sex-specific aging. Emily Brown.
D148 - 9:00 Progenitor expansion and competence are controlled by Lsd1, PRC2 and non-coding RNAs. Ming-Chia Lee.
D149 - 9:15 A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan. Stephen Helfand.
Friday, July 15 8:00 AM – 9:30 AM
Crystal Ballroom G1
Technological Innovations
| Moderator: | Francois Spitz, Institute Pasteur, Paris, France |
Theme: New Technology and Resources
M253 - 8:00 3D image analysis of embryonic lethal mutations: An IMPC/KOMP2 resource. Mary Dickinson.
M278 Unused program number
M279 - 8:30 A Cross-Species Novel Genetic Cell Ablation Technology Involving CD59 and Intermedilysin. Elizabeth Bryda.
M280 - 8:45 RNAi and CRISPR/Cas9 based In Vivo Models for Drug Discovery. Prem Premsrirut.
M281 - 9:00 CRISPR/Cas9 Genome Editing Pipeline for Mice and Rats. Thom Saunders.
M282 - 9:15 Easy-(Isi)-CRISPR; a method to efficiently knock-in long DNA inserts. Channabasavaiah Gurumurthy.
Friday, July 15 8:00 AM – 9:30 AM
Crystal Ballroom J1, K-L
Cryptic Variation and Robustness
| Moderator: | Bret Payseur, University of Wisconsin, Madison |
Theme: Evolution and Quantitative Biology
P344 - 8:00 The genomic architecture of interactions between natural polymorphisms and environments in yeast growth. Xinzhu Wei.
P345 - 8:15 How to make drug resistance evolution “difficult”: a lesson on epistasis and robustness in malaria parasites. Thanat Chookajorn.
P346 - 8:30 Investigating cryptic genetic variation through position effect variegation in a panel of Drosophila melanogaster inbred lines. Joyce Kao.
P347 - 8:45 The cost of noise in biochemical reactions and the evolutionary limits of cellular robustness. J. David Van Dyken.
P348 - 9:00 Selection transforms the genetic landscape of Hsp90-interacting variation. Kerry Geiler-Samerotte.
P349 - 9:15 Genetic and cellular architecture of parentally biased seed size determinants. Jonathan Fitz Gerald.
Friday, July 15 8:00 AM – 9:30 AM
Crystal Ballroom G2
Division and Development
| Moderator: | Yona Kassir, Technion Institute, Haifa, Israel |
Theme: Neuroscience, Systems to Molecules
Y490 - 8:00 A trade-off between invasion and sexual reproduction is mediated by the DNA-binding mechanism of a conserved transcription factor. Michael Dorrity.
Y491 - 8:15 Meiotic Crossing Over Requires Attenuation of an Intrinsic Degron in the MutS Homolog Msh4. Neil Hunter.
Y492 - 8:30 The ascus persists after post-germination budding and influences bud-vs-mate decisions in S. cerevisiae. Michael McMurray.
Y493 - 8:45 Kar4p regulates meiosis at both the transcriptional and translational levels. Mark Rose.
Y494 - 9:00 A cytokinesis checkpoint. Eric Weiss.
Y495 - 9:15 The CWI Pathway Regulates Cell Wall Degradation During Mating. Allison Hall.
Friday, July 15 8:00 AM – 9:30 AM
Grand Ballroom 7A
Models of Human Disease
| Moderator: | James Amatruda, University of Texas Southwestern Medical Center |
Theme: Disease Models and Aging
Z579 - 8:00 Identifying roles for Pbx factors in heart development and congenital heart defects using zebrafish genome engineering. Lisa Maves.
Z580 - 8:15 An essential splice site mutation in flt1 protects against early-stage atherosclerosis in zebrafish larvae. Marcel den Hoed.
Z581 - 8:30 Mutations in COL22A1 cause a loss of vascular integrity that result in intracranial aneurysms. Quynh Ton.
Z582 - 8:45 Cure modeling human genetic skeletal muscle disorders. Noriko Umemoto.
Z583 - 9:00 Fmrp interacts with Adar and regulates RNA editing, synaptic density and locomotor activity in zebrafish. Adi Shamay-Ramot.
Z584 - 9:15 Pyruvate carboxylase functions in astrocytes to regulate habituation learning. Marc Wolman.
Friday, July 15 8:00 AM – 9:30 AM
Grand Ballroom 7B
Evolution
| Moderator: | James Lister, Virginia Commonwealth University |
Theme: Evolution and Quantitative Biology
Z585 - 8:00 Introgression in Zebrafish and related species was mediated by genome structure. Braedan McCluskey.
Z586 - 8:15 Regulation of actinodin1 in embryonic fins via tissue-specific cis-acting regulatory elements: a potential mechanism for the loss of these genes during the fin-to-limb transition. Robert Lalonde.
Z587 - 8:30 The MITF family member tfec functions in zebrafish neural crest pigment cell fate diversification. James Lister.
Z588 - 8:45 Evolutionary Conservation of Tcf12 and Twist1 Function in Coronal Suture Development. Camilla Teng.
Z589 - 9:00 Fish synovial joints as new models for joint development and disease. Joanna Smeeton.
Z590 - 9:15 Cavefish evolution as a natural model for metabolic diseases. Nicolas Rohner.
Friday, July 15 10:00 AM – 12:00 NOON
Grand Ballroom 8A
Cell Cycle, Cell Division, Cytokinesis
| Moderator: | Mi Hye Song, Oakland University, MI |
Theme: Intracellular Dynamics
W427 - 10:00 Hemicentin regulates Anillin to promote cytokinesis in Caenorhabditis elegans germ cells. Yu Chung Tse.
W428 - 10:15 ATX-2, The C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics. Michael Stubenvoll.
W429 - 10:30 Developing quantitative resource for computational analysis from images of C. elegans embryogenesis in a public database Phenobank. Yukako Tohsato.
W430 - 10:45 PAR polarity proteins promote enhanced spindle assembly checkpoint activity in germline blastomeres. Abigail Gerhold.
Friday, July 15 10:00 AM – 12:00 NOON
Palms Ballroom Canary 2
Chromatin Structure and Chromatin Modification
| Co-Moderators: | Martin Simon, Saarland University, Germany, and Sean Taverna, John's Hopkins University, MD |
Theme: Genomics and Gene Regulation
- 10:00 Session Introduction.
C41 - 10:15 Cell cycle control of histone methyltransferase TXR1 levels is required for proper DNA replication in Tetrahymena. Shan Gao.
C42 - 10:30 Functional analysis of the Ibd1 protein in Terahymena thermophila. Alejandro Saettone.
C43 - 10:45 GCN5, ESA1, and CHD1: More Than Just Transcription Regulators? Joshua Smith.
C44 - 11:00 MAC-specific Chromatin Remodelers bind a Zinc Finger Protein and Diverse RNAs throughout the Tetrahymena Life Cycle. Eva DeRango-Adem.
C45 - 11:15 Homology dependent heterochromatin formation by trans acting RNAi in Paramecium tetraurelia. Martin Simon.
C46 - 11:30 The Enhancer of zeste like protein Ezl1 is required for scnRNA selection and transcriptional repression of transposon-derived sequences in Paramecium tetraurelia. Andrea Frapporti.
C47 - 11:45 Proteomic Characterization of Tetrahymena thermophila Chromatin Assembly Proteins. Jyoti Garg.
Friday, July 15 10:00 AM – 12:00 NOON
Palms Ballroom Sago
Physiology, Organismal Growth and Aging
| Co-Moderators: | Ting Xie, Stowers Institute for Medical Research, and Jason Tennessen, Indiana University Bloomington, and Matt Sieber, Carnegie Institute for Science |
Theme: Development and Morphogenesis
D150 - 10:00 The sexual identity of adult intestinal stem cells controls organ size and plasticity. Bruno Hudry.
D151 - 10:15 Mechanisms underlying sexually dimorphic growth. Annick Sawala.
D152 - 10:30 Body weight dependent autophagy induction mediates metamorphic timing control under nutrient restriction in Drosophila. Xueyang Pan.
D153 - 10:45 A SANT-like domain-containing protein regulates lipid droplet size. Xun Huang.
D154 - 11:00 Identification and Characterization of a Novel Gene that Regulates Mitochondrial DNA Replication. Jessica Tang.
D155 - 11:15 Circadian mutants lacking either period or timeless have an extended longevity phenotype due to altered mitochondrial function. Michele Shirasu-Hiza.
D156 - 11:30 Histidine metabolism perturbations inhibit neural tumours dependent on Myc-mediated dedifferentiation. Francesca Froldi.
D157 - 11:45 Ecology of the gut microbiome determines fly health. William Ludington.
Friday, July 15 10:00 AM – 12:00 NOON
Palms Ballroom Sabal
Techniques and Resources
| Co-Moderators: | Norbert Perrimon, Harvard Medical School, and Kate O'Connor-Giles, Univ. of Wisconsin- Madison, and Benjamin Housden , Harvard Medical School |
Theme: New Technology and Resources
D158 - 10:00 Genome-wide spatial-temporal gene expression pattern prediction in Drosophila melanogaster embryonic development. Jian Zhou.
D159 - 10:15 Measuring exercise in Drosophila: Characterization of the Rotating Exercise Quantification System (R.E.Q.S.). Louis Watanabe.
D160 - 10:30 Features and Applications of FlyCircuit Database – From Fluorescent Images to the Drosophila Connectome. Chi-Tin Shih.
D161 - 10:45 High-speed imaging of neural spiking and dendritic dynamics in awake flies with a fluorescent voltage sensor. Cheng Huang.
D162 - 11:00 Effective knockdown of Drosophila long noncoding RNAs by CRISPR interference. Ji-Long Liu.
D163 - 11:15 Optimized synthetic lethal screening approaches for drug target discovery in Drosophila. Benjamin Housden.
D164 - 11:30 CRISPR/Cas9-based tools for in vivo transcriptional activation and repression in Drosophila. Ben Ewen-Campen.
D165 - 11:45 A novel 96 well system for housing, manipulating and feeding flies. Maria Jaime.
Friday, July 15 10:00 AM – 12:00 NOON
Palms Ballroom Royal
RNA Biology
| Co-Moderators: | Howard Lipshitz, Univ. of Toronto, and Ben Brown, Lawrence Berkeley Natl. Laboratory, and John Laver, University of Toronto |
Theme: Genomics and Gene Regulation
D166 - 10:00 Neuronal 3'UTR extension: ELAV links Pol II pausing to alternative polyadenylation. Valerie Hilgers.
D167 - 10:15 Mutant rescue by inhibition of nonsense mediated decay. Mark Metzstein.
D168 - 10:30 The Drosophila hnRNP F/H homolog, Glorund, Uses Two Distinct RNA Binding Modes to Differentially Regulate its Targets. Elizabeth Gavis.
D169 - 10:45 The TREX complex suppresses piRNA precursor splicing and promotes assembly of piRNA cluster heterochromatin. GEN ZHANG.
D170 - 11:00 From egg to adult: piRNA-mediated silencing throughout germline development in Drosophila melanogaster. Pauline Marie.
D171 - 11:15 Nano-exons in Drosophila. Stephen Mount.
D172 - 11:30 Identifying genetic modifiers of FUS toxicity in a drosophila model of ALS. Udai Pandey.
D173 - 11:45 A high-throughput pipeline for the production of synthetic antibodies for analysis of ribonucleoprotein complexes. John Laver.
Friday, July 15 10:00 AM – 12:00 NOON
Crystal Ballroom G1
Human Disease Models 1
| Moderator: | Monica Justice, Sickkids, Toronto, Ontario, Canada |
Theme: Disease Models and Aging
M283 - 10:00 Modeling the Gene: Maternal environment interaction in neurodevelopmental disorders. Freda Miller.
M284 - 10:30 An inducible dominant negative allele of Sox10 models neurocristopathy deficits characteristic of PCWH patients. Michelle Southard-Smith.
M285 - 10:45 Alpha-synuclein, the cause of Parkinson's disease, has a vital function in aged mice. Deborah Cabin.
M286 - 11:00 Aberrant DNA binding by mutant (E339D) KLF1 induces upregulation of embryonic β-globin in adult mice. Danitza Nebor.
M287 - 11:15 Mutations in beta spectrin protect mice from malaria by increasing parasite susceptibility to clearance. Gaetan Burgio.
M288 - 11:30 Interaction of BRCA2 and PALB2 is essential for genome stability. Suzanne Hartford.
M289 - 11:45 Pathophysiological responses to dietary patterns differ with genetic backgrounds. William Barrington.
Friday, July 15 10:00 AM – 12:00 NOON
Crystal Ballroom J1, K-L
Mutation and Recombination
| Moderator: | Michael Lynch, Indiana University, Bloomington |
Theme: Evolution and Quantitative Biology
P350 - 10:00 An X×Y genetic interaction mediates global crossover frequency in house mice. Beth Dumont.
P351 - 10:15 CRISPR-directed mitotic recombination enables genetic mapping without crosses. Meru Sadhu.
P352 - 10:30 Genetic analysis of an intermediate phenotype for recombination rate variation. Richard Wang.
P353 - 10:45 Replication timing generates conserved base-substitution mutation rates in concurrently replicated regions of mismatch repair deficient bacterial genomes. Vaughn Cooper.
P354 - 11:00 Decomposing intra-genomic heterogeneity in mutation bias in coding sequences. Cedric Landerer.
P355 - 11:15 Transposon-induced genome rearrangements in maize: mechanisms and genetic impacts. Thomas Peterson.
P356 - 11:30 Evidence for the interspecies transfer of a driving X chromosome. Christopher Leonard.
P357 - 11:45 The mutational structure of metabolism in Caenorhabditis elegans. Charles Baer.
Friday, July 15 10:00 AM – 12:00 NOON
Crystal Ballroom G2
YGM Lifetime Achievement Award: James Broach and Scientific Session Stress Sensing and Damage Control
| Moderator: | Oliver Kerscher, The College of William and Mary, Williamsburg, VA |
Theme: Neuroscience, Systems to Molecules
Y496 - 10:00 "Flipping the Switch": ROS-induced degradation of Med13 by SCFGrr1 mediates mitochondrial fragmentation and cell death. David Stieg.
Y497 - 10:15 Protein sequestration after genotoxic stress regulates splicing. Peter Stirling.
Y498 - 10:30 The DNA damage checkpoint targets the exoribonuclease, Xrn1, in response to damage. Jessica Lao.
Y499 - 10:45 The lysine acetyltransferase NuA4 regulates glucose-deprived stress granule formation through cellular acetyl-CoA levels. Sylvain Huard.
Y500 - 11:00 The Quick and the Dead: Single-cell Demography at the Yeast Thermal Limit. Paul Magwene.
Y501 - 11:15 The RSC complex functions to maintain ploidy in Saccharomyces cerevisiae. Tina Sing.
Y502 - 11:30 Yeast Genetics Meeting Lifetime Achievement Award. James Broach.
Friday, July 15 10:00 AM – 12:00 NOON
Grand Ballroom 1-2
Emerging Technologies - Imaging
| Moderator: | Kristen Kwan, University of Utah |
Theme: New Technology and Resources
Z591 - 10:00 in toto imaging of osteoblast cell cycle dynamics in regenerating zebrafish scales. Ben Cox.
Z592 - 10:15 Plasticity & Robustness in Gastrulation: Siamese Zebrafish. Antonio Ortiz.
Z593 - 10:30 Spatiotemporal regulation of metalloprotease activity in DV patterning. Francesca Tuazon.
Z594 - 10:45 Automated approaches to sample handling and high-throughput behavioral screening of zebrafish. Ravindra Peravali.
Z595 - 11:00 Quantitative in vivo optical tomography of cancer progression and vasculature development in adult zebrafish. Nicola Lockwood.
Z596 - 11:15 Pancellular, whole-organism tissue microCT as a basis for organismal phenomics. Keith Cheng.
Z597 - 11:30 Automated Segmentation and Morphological Characterization of Neuronal Cell Nuclei in Synchrotron MicroCT Images of Whole Zebrafish. Yifu Ding.
Z598 - 11:45 Diverse structures and functions of pharyngeal teeth in teleost (zebrafish, medaka, carp, snowflake moray) live-imaged by synchrotron X-ray cinematography. Kohei Hatta.
Friday, July 15 10:00 AM – 12:00 NOON
Grand Ballroom 7B
Signaling
| Moderator: | Anming Meng, Tsinghua University, China |
Theme: Disease Models and Aging
Z599 - 10:00 Calcium signalling mediated by tmem33 is essential for endothelial tip cell function during angiogenesis in zebrafish. Aaron Savage.
Z600 - 10:15 Lgr6 Is A Wnt Target That Promotes Support Cell Proliferation In The Regenerating Lateral Line Neuromast. Jonathan Kniss.
Z601 - 10:30 In vivo ranking of RASopathy MEK1 variants using functional assays in zebrafish and Drosophila. Granton Jindal.
Z602 - 10:45 Hedgehog Signaling in Choroid Fissure Formation and Coloboma. Hannah Gordon.
Z603 - 11:00 The role of the Nkd EF-hand in modulating Wnt signaling outputs. Autumn Marsden.
Z604 - 11:15 Glycolysis meets Fgf signaling: The glycolytic enzyme PGK1 is required non-autonomously for Fgf-dependent specification of otic neurons in zebrafish. Bruce Riley.
Z605 - 11:30 Shh promotes direct interactions between epidermal cells and osteoblast progenitors to shape regenerated zebrafish bone. Kryn Stankunas.
Z606 - 11:45 A genetic mechanism to sense and respond to enhanced cellular sphingosine levels during development. Todd Evans.
Friday, July 15 10:00 AM – 12:00 NOON
Grand Ballroom 7A
Organogenesis (Mesoderm, Endoderm, Ectoderm)
| Moderator: | Iain Drummond, MGH/Harvard Medical School, MA |
Theme: Development and Morphogenesis
Z607 - 10:00 Developmental origin of muscle-associated fibroblasts. Peng Huang.
Z608 - 10:15 Hepatic nuclear receptor 4 alpha mediates microbial control of host gene expression in the zebrafish digestive tract. James Davison.
Z609 - 10:30 Deciphering the role of Isl1 in enteroendocrine cell differentiation. Marianne Voz.
Z610 - 10:45 Liver-enriched gene 1, a glycosylated secretory protein, binds to FGFR and mediates an anti-stress pathway to protect liver development in zebrafish. Jinrong Peng.
Z611 - 11:00 Macrophages mediate the repair of brain vascular rupture through direct physical adhesion and mechanical traction. Lingfei Luo.
Z612 - 11:15 Wnt signaling is required for adult zebrafish kidney regeneration. Caramai Kamei.
Z613 - 11:30 Gain-of-function mutations of mau/DrAqp3a influence zebrafish pigment pattern formation through the tissue environment. Anastasia Eskova.
Z614 - 11:45 Evidence for ECM-Sema3d interactions controlling skeletal regeneration in the fin. M. Kathryn Iovine.
Friday, July 15 11:00 AM – 12:00 NOON
Grand Ballroom 8A
Cell Polarity and Cell Fate
| Moderator: | Geraldine Seydoux, Johns Hopkins University, Baltimore, MD |
Theme: Intracellular Dynamics
W431 - 11:00 The balance of PAR polarity dictates cellular division patterning. Yen Wei Lim.
W432 - 11:15 Unraveling cell polarity dynamics with single-cell biochemistry. Daniel Dickinson.
W433 - 11:30 A Critical Role for Lipid Synthesis and Polyunsaturated Fatty Acids in C. elegans Early Embryonic Development. Jason Watts.
W434 - 11:45 The forkhead transcription factor UNC-130 integrates both BMP and Notch signaling to regulate dorsoventral patterning of the C. elegans postembryonic mesoderm. Qinfang Shen.
Friday, July 15 4:00 PM – 6:00 PM
Grand Ballroom 8A
Cell Patterning and Morphogenesis
| Co-Moderators: | Ronen Zaidel-Bar, National University of Singapore, and Michel Labouesse, IBPS, Paris, France |
Theme: Development and Morphogenesis
W435 - 4:00 VPR-1 MSP domains coordinate reproductive development with striated muscle metabolism. Timothy Cole.
W436 - 4:15 Sensory Activity Maintains Proper Neural Connectivity in C. elegans. Joy Li.
W437 - 4:30 A transient, pre-cuticular apical extracellular matrix defines tiny tube diameter. Jennifer Cohen.
W438 - 4:45 Rotating and elongating embryos: SPIM microscopy reveals how planar polarity could be established during morphogenesis. Xinyi Yang.
W439 - 5:00 UNC-33/CRMP inhibits growth cone protrusion in axon repulsion from UNC-6/netrin. Mahekta Gujar.
W440 - 5:15 WAVE/SCAR promotes alpha-catenin accumulation and junctional maturation in developing C. elegans epithelia. Martha Soto.
W441 - 5:30 Mechanical forces drive neuroblast morphogenesis and are required for epidermal enclosure. Alisa Piekny.
W442 - 5:45 Morphogenic movements and cell signalling events during gland cell and pharyngeal organ development in Caenorhabditis elegans. Jay Kormish.
Friday, July 15 4:00 PM – 6:00 PM
Palms Ballroom Canary 2
Ciliate Signaling Systems: Signal Transduction, Protein Secretion, and Trafficking
| Co-Moderators: | Megan Valentine, University of Vermont, Burlington, and Sabrice Guerrier, Millsaps College, Jackson, MS |
Theme: Intracellular Dynamics
C48 - 4:00 Signaling and Cell Cycle Studies in Tetrahymena thermophila. Ronald Pearlman.
C49 - 4:30 A potential role for TtSNX4 in macronuclear degradation in Tetrahymena thermophila Conjugation. Sabrice Guerrier.
C50 - 4:45 Characterization of the ubiquitin-like modifier Urm1 in the Ciliate Tetrahymena thermophila. Jennifer Copeland.
C51 - 5:00 Early stages of diversification in the Rab GTPase gene family revealed by genomic and functional studies in Paramecium species. Lydia Bright.
C52 - 5:15 The detection of intracellular cAMP fluctuations – a sensitive in vivo assay to investigate signal transduction pathways in Tetrahymena thermophila. Daniel Romero.
C53 - 5:30 Polycystin-2 (Pkd2) and its unexpected role in Mg2+ permeability in Paramecium. Megan Valentine.
C54 - 5:45 Whole genome sequencing of a Tetrahymena mutant reveals that VPS8, a subunit of the CORVET complex, is essential for biogenesis of mucocysts. Daniela Sparvoli.
Friday, July 15 4:00 PM – 6:00 PM
Palms Ballroom Sago
Cell Biology and Signal Transduction
| Co-Moderators: | Margot Quinlan, Univ. of California, Los Angeles, and Lucy O'Brien, Stanford University, and Parthive Patel, German Cancer Research Center (DKFZ) - Center for Molecular Biology, University of Heidelberg (ZMBH) Alliance |
Theme: Intracellular Dynamics
D174 - 4:00 Intercellular Ca2+ transients integrate spatiotemporal morphogenetic patterning in the Drosophila wing imaginal disc. Qinfeng Wu.
D175 - 4:15 Rewiring regulatory feedback in BMP morphogen signaling. Jennifer Gawlik.
D176 - 4:30 Minibrain and Wings apart control organ growth and tissue patterning through downregulation of Capicua. Liu Yang.
D177 - 4:45 Muscle derived TGF-β growth factor Myoglianin regulates size of imaginal wing discs. Ambuj Upadhyay.
D178 - 5:00 The Drosophila tumor suppressor Tid/Alg3 controls TNFR/JNK signaling through glycosylation. Geert de Vreede.
D179 - 5:15 A kinome-wide RNAi screen in Drosophila glia and human GBM models reveals Stk17A drives neoplastic glial proliferation. Joanna Wardwell-Ozgo.
D180 - 5:30 Wnt proteins serve as directional cues for the Par-complex polarity and the Drosophila nervous tissue growth. Shigeki Yoshiura.
D181 - 5:45 Motile stem cells exhibit tissue-level spatial order during homeostasis but not growth of the adult Drosophila midgut. XinXin Du.
Friday, July 15 4:00 PM – 6:00 PM
Palms Ballroom Sabal
Drosophila Models of Human Disease I
| Co-Moderators: | Hugo Bellen, Baylor College of Medicine, and Hannele Ruohola-Baker, University of Washington, and Rebecca Kreipke, University of Washington |
Theme: Disease Models and Aging
D182 - 4:00 Identification of Alzheimer’s disease as a neurodegenerative laminopathy. Bess Frost.
D183 - 4:15 Defects in synaptic vesicle endocytosis are caused by TDP-43 dependent translation inhibition in a Drosophila model of ALS. Alyssa Coyne.
D184 - 4:30 Glial expression of spen confers a Notch-dependent resistance to paraquat. Nathalie Davoust.
D185 - 4:45 The ecdysone and JAK/STAT pathways regulate proper morphogenetic movement of squamous cells by suppressing Notch-induced Broad. Allison Jevitt.
D186 - 5:00 Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic muscle. Nikolay Kandul.
D187 - 5:15 A Drosophila model for XX Gonadal Dysgenesis. Offer Gerlitz.
D188 - 5:30 Mechanism of Ethanol Tolerance: ChIP-seq to identify the signature of ethanol tolerance genes. Nigel Atkinson.
D189 - 5:45 A Drosophila Model of Essential Tremor. Lorraine Clark.
Friday, July 15 4:00 PM – 6:00 PM
Palms Ballroom Royal
Regulation of Gene Expression I
| Co-Moderators: | Julie Zeitlinger, Stowers Institute for Medical Research, and Michele Markstein, University of Massachusetts, and Robin Fropf, Stowers Institute for Medical Research |
Theme: Genomics and Gene Regulation
D190 - 4:00 Modulation of bursting kinetics generates specific gene expression rates in the early embryo. Shawn Little.
D191 - 4:15 A fully synthetic transcriptional enhancer platform for study of regulatory protein function in a multicellular eukaryote. Justin Crocker.
D192 - 4:30 Developmental Regulomes – Resolving Enhancer-Protein Interactions with Temporal and Tissue-Specificity. Robert Zinzen.
D193 - 4:45 Application of ChIP-nexus to map transcription factors during development. Robin Fropf.
D194 - 5:00 Natural variation in binding site affinity controls stochastic gene expression in the fly eye. Caitlin Anderson.
D195 - 5:15 Towards a 4D understanding of chromatin architecture and transcriptional regulation. Hongtao Chen.
D196 - 5:30 Zelda pioneers early enhancers during genome activation. Christine Rushlow.
D197 - 5:45 Highly accurate prediction of early anterior-posterior enhancer sequences from ChIP-seq data. Hamutal Arbel.
Friday, July 15 4:00 PM – 6:00 PM
Crystal Ballroom G1
Epigenetics
| Moderator: | Philippe Soriano, Mt. Sinai Hospital, New York |
Theme: Genomics and Gene Regulation
M290 - 4:00 Xist RNA, its interactome, and consequences of their disruption in vivo. Jeannie Lee.
M291 - 4:30 Allelic imbalance is a prevalent and tissue-specific feature of autosomal and X-linked genes in F1 hybrid mice. Stefan Pinter.
M292 - 4:45 Vive la difference: zooming in on sex-specific differences in mouse embryonic stem cells. Nora Engel.
M293 - 5:00 Genetic control of the epigenetic landscape. Christopher Baker.
M294 - 5:15 Genetic Variation Mediates the Epigenetic Response to Corticosteroids in Mice. Gregory Carter.
M295 - 5:30 EZH2 Isoforms Differentially Regulate the Function of Polycomb Repressive Complex 2. Weipeng Mu.
M296 - 5:45 The function of the histone demethylase KDM1A (LSD1) in Tau mediated neurodegeneration. David Katz.
Friday, July 15 4:00 PM – 6:00 PM
Crystal Ballroom J1, K-L
Molecular Evolution
| Moderator: | Dmitri Petrov, Stanford University, CA |
Theme: Evolution and Quantitative Biology
P358 - 4:00 Ongoing duplicate gene resolution shapes diversified metabolic networks: a functional comparative study of two yeast GALalactose utilization networks. Meihua Kuang.
P359 - 4:15 Young proteins are less ordered, showing preadaptation for de novo gene birth. Benjamin Wilson.
P360 - 4:30 Lineage dynamics in adapting yeast populations. Julia Piper.
P361 - 4:45 Exploration of bioactive peptides from random sequences: an experimental approach to de novo gene evolution. Rafik Neme.
P362 - 5:00 Molecular evolution and population dynamics of herbicide resistance in Amaranthus palmeri: rapid proliferation of a highly conserved gene modulated by population structure. Amy Lawton-Rauh.
P363 - 5:15 Secreted Proteins evade the Expression – Rate Anticorrelation. Felix Feyertag.
P364 - 5:30 The fitness landscape of a tRNA gene. Chuan Li.
P365 - 5:45 The Critical Functions Encoded by Synonymous Sites. Heather Machado.
Friday, July 15 4:00 PM – 6:00 PM
Crystal Ballroom G2
Yeast Evolution in and out of the Lab
| Moderator: | Helen Murphy, The College of William and Mary, Williamsburg, VA |
Theme: Neuroscience, Systems to Molecules
Y503 - 4:00 A comprehensive genotype-fitness map of adaptation-driving mutations in yeast. Barbara Dunn.
Y504 - 4:15 Extrachromosomal Circular DNA – A Key Player in Creation of Copy Number Variation? Henrik Møller.
Y505 - 4:30 Deciphering common principles governing gene replaceability in yeast. Aashiq Kachroo.
Y506 - 4:45 The 1002 yeast genomes project. Joseph Schacherer.
Y507 - 5:00 Integrative Analysis of the Variation in the Regulatory Network Among Strains of Yeast. Rohith Srivas.
Y508 - 5:15 Comparative translatomics reveal a conserved class of noncanonical uORFs in yeast. Joel McManus.
Y509 - 5:30 Mating-type switching in the methylotrophic yeast Hansenula polymorpha is regulated by yeast mating and differentiation pathways. Sara Hanson.
Y510 - 5:45 The 3D organization of the diploid Saccharomyces genome. Seungsoo Kim.
Friday, July 15 4:00 PM – 6:00 PM
Grand Ballroom 7A
Highlighted Talks, International Zebrafish Society Awards Ceremony, announcement of the George Streisinger Award winner and Community Meeting
| Moderator: | Rebecca Burdine, Princeton University, NJ |
Z615 - 4:00 Positional cloning of cloche, a gene that drives endothelial and hematopoietic lineage specification. Didier Stainier.
Z616 - 4:30 IZFS Chi-Bin Chien Award - Molecular asymmetry at electrical synapses – at the gap and beyond. Adam Miller.
Community Meeting
- 5:00 Conference Announcements.
- 5:15 Resource Center Presentations.
- 5:30 Open Community Discussion.
Friday, July 15 7:30 PM – 9:30 PM
Palms Ballroom Sago/Sabal/Royal
Development and Evolution Joint Plenary Session
| Moderator: | Jeannie Lee, Massachusetts Institute of Technology |
Presentations:
J5 - 7:30 The Fred Kavli Foundation Distinguished Lecture: Flexibility and variability in behavior at the gene-environment interface. Cori Bargmann.
J6 - 8:00 Colinear Hox genes regulation in mammals. Denis Duboule.
J7 - 8:30 Of mice, men and birds: meiotic recombination and its evolution. Molly Przeworski.
J8 - 9:00 Fishing for the secrets of stickleback and human evolution. David Kingsley.
Saturday, July 16 1:45 PM – 3:45 PM
Grand Ballroom 8A
Meiosis, Germ Line Development, and Sex Determination
| Co-Moderators: | Anne Villeneuve, Stanford University School of Medicine, CA, and Christian Eckmann, Martin Luther University, Saale, Germany |
Theme: Stem Cell, Regeneration and Germline
W443 - 1:45 DAF-7/TGFβ signaling in the C. elegans germline stem cell niche. Olga Pekar.
W444 - 2:00 The combined activity of CPB-1CPEB and GLD-3Bic-C opposes FBFPum to prevent the sperm-to-oocyte switch in C. elegans males. Christian Eckmann.
W445 - 2:15 top-2 is required for proper chromosome segregation during male meiosis in C. elegans. Aimee Jaramillo-Lambert.
W446 - 2:30 The t-SNARE syx-7 promotes cytokinesis during sperm meiosis. Kristin Fenker.
W447 - 2:45 Signaling sperm to stop or go: the seminal fluid protease inhibitor SWM-1 regulates C. elegans sperm motility. Daniela Chavez.
W448 - 3:00 The sperm TRP family channel TRP-3 induces a calcium wave in the fertilized oocyte of C. elegans. Jun Takayama.
W449 - 3:15 Maternal MEMI specifies the female meiosis II program in C. elegans. Martin Srayko.
W450 - 3:30 ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in C. elegans. Dustin Updike.
Saturday, July 16 1:45 PM – 3:45 PM
Palms Ballroom Canary 2
Cell Motility: Cilia, Basal Bodies, and Tubulin
| Co-Moderators: | Jacek Gaertig, University of Georgia, Athens, and Anne-Marie Tassin, CNRS, Gif-sur-Yvette, France |
Theme: Intracellular Dynamics
C55 - 1:45 Using Chlamydomonas to understand cilia assembly. Susan Dutcher.
C56 - 2:15 Role of molecular motors and microtubule-binding proteins in cell polarity and regeneration of Stentor. Tatyana Makushok.
C57 - 2:30 Kinome analysis in the giant ciliate Stentor coeruleus. Sarah Reiff.
C58 - 2:45 Forward Genetics in Tetrahymena thermophila by a Modified Pooled Linkage: Identification of Causative Mutations Related to Cell Division and Ciliogenesis. Yuyang Jiang.
C59 - 3:00 Paramecium as a model to study human ciliopathies: study of a transition zone protein, MKS2. Anne-Marie Tassin.
C60 - 3:15 Sfr proteins that transiently localize to the basal bodies during assembly. Mark Winey.
C61 - 3:30 Stabilizing basal bodies to resist asymmetric ciliary forces. Chad Pearson.
Saturday, July 16 1:45 PM – 3:45 PM
Palms Ballroom Sago
Organelles and Trafficking
| Co-Moderators: | Helmut Kramer, UT Southwestern Medical Center, and Amy Kiger, Univ. of Calif., San Diego, and Kari Lenhart, University of Pennsylvania School of Medicine |
Theme: Development and Morphogenesis
D198 - 1:45 ESCRTs and intraluminal vesicles play novel roles in controlling exosome heterogeneity, late endosomal acidification and regulated secretion. Benjamin Kroeger.
D199 - 2:00 Mitophagy is dispensable for axonal maintenance during normal aging in Drosophila. Yanshan Fang.
D200 - 2:15 Endosomal Microautophagy: a genetic model in Drosophila. Anindita Mukherjee.
D201 - 2:30 Mechanisms of rapid, membrane-dependent furrow formation in the early Drosophila embryo. James Blankenship.
D202 - 2:45 The Voltage Gated Chloride Channels CLC-b and CLC-c play critical roles in lifespan and cell viability respectively. Richard Burke.
D203 - 3:00 A screen for systemic growth regulators reveals hobbit, a novel and conserved regulator of insulin secretion. Sarah Neuman.
D204 - 3:15 Spastic paraplegia proteins help model the axonal endoplasmic reticulum network in Drosophila. Cahir O'Kane.
D205 - 3:30 Asymmetric Endoplasmic Reticulum partitioning is dependent on Jagunal in the early Drosophila embryo. Blake Riggs.
Saturday, July 16 1:45 PM – 3:45 PM
Palms Ballroom Sabal
Drosophila Models of Human Disease II
| Co-Moderators: | Hugo Bellen, Baylor College of Medicine, and Hannele Ruohola-Baker, University of Washington, and Hsiao-Tuan Chao , Texas Childrens Hospital, Clinical Care Center |
Theme: Disease Models and Aging
D206 - 1:45 Inhibiting lipid transfer between neurons and glia by modulating lactate levels delays neurodegeneration. Lucy Liu.
D207 - 2:00 Mitochondrial-nuclear incompatibility during oogenesis causes embryonic lethality. Chunyang Zhang.
D208 - 2:15 dSod1 knock-in mutations cause ALS-like phenotypes in Drosophila. Aaron Held.
D209 - 2:30 JmjC demethylases regulate resistance and tolerance to alcohol in Drosophila. Jorge Pinzon.
D210 - 2:45 Loss of Nardilysin, a chaperone for α-Ketoglutarate Dehydrogenase, causes neurodegeneration in flies and humans and promotes mTORC1 activation. Wan Yoon.
D211 - 3:00 A multi-omics strategy for fly models of human disease in exposure biology. James Brown.
D212 - 3:15 Using the DGRP to identify gene networks associated with autism-like behaviors. Lawrence Reiter.
D213 - 3:30 Defects in phagocytosis by glia and immune cells in a Drosophila model of Fragile X syndrome. Michele Shirasu-Hiza.
Saturday, July 16 1:45 PM – 3:45 PM
Palms Ballroom Royal
Gene Expression and Chromatin
| Co-Moderators: | Julie Zeitlinger, Stowers Institute for Medical Research, and Michele Markstein, University of Massachusetts, and David Doupé, Harvard Medical School |
Theme: Genomics and Gene Regulation
D214 - 1:45 Epigenetic control of ribosome biogenesis homeostasis. Jérôme Deraze.
D215 - 2:00 Specialized Ribosomes: eRpL22 paralogue-specific ribosomes translate specific mRNAs in the Drosophila testis. Catherine Mageeney.
D216 - 2:15 Translational compensation of segmental aneuploidy in Drosophila melanogaster. Zhenguo Zhang.
D217 - 2:30 When One Plus One Does Not Equal Two: Some Tandem Gene Duplicates are Overactive. David Loehlin.
D218 - 2:45 A double assurance mechanism controls enhancer-promoter specificity at the hunchback locus. Jia Ling.
D219 - 3:00 Tailless repression sets pair-rule stripes and gap domains. Luiz Andrioli.
D220 - 3:15 Enzymatic modules of the SAGA chromatin-modifying complex play distinct roles in Drosophila gene expression and development. Xuanying Li.
D221 - 3:30 An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1. Scott Barolo.
Saturday, July 16 1:45 PM – 3:45 PM
Crystal Ballroom G1
Cancer and Immunology
| Moderator: | Viive Howell, The University of Sydney, Australia |
Theme: Disease Models and Aging
M297 - 1:45 Engineering the Cancer Genome. Tyler Jacks.
M298 - 2:15 Genetic inhibition of MTOR during thymic Pre-T LBL development delays tumorigenesis and points to the IRF4-CDK6 pathway as a potential target in the treatment of T-ALL/LBL. Beverly Mock.
M299 - 2:30 Adenoma Susceptibility Modulated by Variable Complex Gut Microbiota in a Rat Model of Familial Colon Cancer. Susheel Bhanu Busi.
M300 - 2:45 The aggressive prostate cancer susceptibility gene HIST1H1A is a modulator of androgen receptor signaling and epithelial to mesenchymal transition. Kendra Williams.
M301 - 3:00 Polymorphisms in the Arntl2 promoter affect metastatic susceptibility in estrogen-receptor negative breast cancer. Kent Hunter.
M302 - 3:15 Glioma modeling with MADM, a mouse genetic mosaic system, revealed cell competition as the mechanism that enables inevitable malignant progression. Hui Zong.
M303 - 3:30 Host-pathogen genetic interactions drive outcome to tuberculosis in the Collaborative Cross. Clare Smith.
Saturday, July 16 1:45 PM – 3:45 PM
Crystal Ballroom J1, K-L
Population Genetics
| Moderator: | Lauren McIntyre, University of Florida, Gainesville |
Theme: Evolution and Quantitative Biology
P366 - 1:45 Estimation of Population Phylogeny in an IM framework, with Applications to African Human Hunter Gatherer Populations. Jody Hey.
P367 - 2:00 The genetic diversity of a population experiencing selection. Ivana Cvijovic.
P368 - 2:15 Estimation of effective number of stem cells in Dugesia worms using temporal variance of allele frequencies. Hosseinali Asgharian.
P369 - 2:30 Estimating ages of singletons and other rare alleles. Alexander Platt.
P370 - 2:45 Genetic Interrelationships between Zika Virus, Dengue Virus, Chikungunya Virus and Yellow Fever Virus Strains. Olaitan Awe.
P371 - 3:00 Beneficial mutations improve fitness in a Caenorhabditis elegans line evolved under conditions of extreme genetic drift. Stephen Christy.
P372 - 3:15 Homoploid hybrid speciation in the wild: yeasts do it too. Guillaume Charron.
P373 - 3:30 The correlation across populations of mutation effects on fitness. Ryan Gutenkunst.
Saturday, July 16 1:45 PM – 3:45 PM
Crystal Ballroom G2
Revisiting Classical Genetics with New Technology
| Moderator: | Aimee Dudley, Pacific Northwest Research Institute, Seattle, WA |
Theme: Neuroscience, Systems to Molecules
Y511 - 1:45 A global yeast genetic network maps cellular function. Michael Costanzo.
Y512 - 2:00 A programmable sensor for protein solubility in yeast uncovers ecological prion-switching factors. Gregory Newby.
Y513 - 2:15 Identifying synthetic cytotoxic genetic interactions with DNA damaging therapeutic agents. Xuesong Li.
Y514 - 2:30 High throughput protein-protein interaction sequencing using iSeq. Zhimin Liu.
Y515 - 2:45 Scalable tools for the quantitative analysis of chemical-genetic interactions from sequencing-based chemical-genetic interaction screens. Scott Simpkins.
Y516 - 3:00 One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Uri Weill.
Y517 - 3:15 NGS for "No-pain Genetic Screens": Using transposons and Next-Gen Sequencing to unveil all important yeast loci in one go. Agnes Michel.
Y518 - 3:30 Exploring Functional Genetic Suppression Interactions on a Global Scale. Jolanda van Leeuwen.
Saturday, July 16 1:45 PM – 3:45 PM
Grand Ballroom 7A
Neural Development and Regeneration
| Moderator: | Yevgenya Grinblat, University of WI, Madison |
Theme: Neuroscience, Systems to Molecules
Z617 - 1:45 Cell proliferation and differentiation are controlled by different Fgf downstream targets during sensory hair cell regeneration. Mark Lush.
Z618 - 2:00 Cilia genes play differing roles in hair cells. Tamara Stawicki.
Z619 - 2:15 The Agrin receptor Lrp4 promotes peripheral nerve regeneration through a novel, MuSK-independent pathway. Katherine Gribble.
Z620 - 2:30 pregnancy-associated plasma protein-aa (pappaa) mediates the development and function of distinct retinal circuits. Andrew Miller.
Z621 - 2:45 CachD1 is a novel type I transmembrane protein that regulates the development of habenular asymmetry in zebrafish. Ana Faro.
Z622 - 3:00 New pathways required for zebrafish brain Left-Right asymmetry and bilateral symmetry. Michael Rebagliati.
Z623 - 3:15 Roundabout2 and exotosin-like 3 promote target specific peripheral nerve regeneration in vivo. Patricia Murphy.
Z624 - 3:30 MECP2-IGF1 signaling determines how neural circuits interpret sensory information. Nicholas Santistevan.
Saturday, July 16 1:45 PM – 3:45 PM
Grand Ballroom 7B
Cancer
| Co-Moderators: | Liz Patton, Institute for Genetics and Molecular Medicine, UK, and Rebecca Burdine, Princeton University, NJ |
Theme: Intracellular Dynamics
Z625 - 1:45 Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Andrew Cox.
Z626 - 2:00 Single-cell imaging of normal and malignant cell engraftment into optically clear immune deficient zebrafish. Qin Tang.
Z627 - 2:15 Dynamics of innate immunity guided tumor cell motility in vivo. Minna Roh-Johnson.
Z628 - 2:30 tp53-deficient zebrafish models of Malignant Nerve Sheath Tumor, Leukemia, Angiosarcoma, Rhabdomyosarcoma, and Germ cell tumors. Myron Ignatius.
Z629 - 2:45 Investigating novel non-oncogene targets for cancer therapies. Joan Heath.
Z630 - 3:00 Chemical genetic approach identifies role of proton sensing GPR68 in modulation of migration in melanoma. Charles Williams.
Z631 - 3:15 Zebrafish Pediatric Brain Tumor Modeling for Pre-clinical Drug Screening. Rodney Stewart.
Z632 - 3:30 Dissecting the mechanism of oncogenic glutamate receptor signaling in melanocytes and melanoma. Ana Neto.
Saturday, July 16 4:00 PM – 6:00 PM
Grand Ballroom 8A
RNAi, microRNAs, and Developmental Timing
| Co-Moderators: | Julie Claycomb, University of Toronto, Canada, and Antony Jose, University of Maryland, College Park |
Theme: Genomics and Gene Regulation
W451 - 4:00 Cell-cycle quiescence maintains C. elegans germline stem cells independent of GLP-1/Notch. Hannah Seidel.
W452 - 4:15 Beyond Cell Death: Systematic Analyses of Non-apoptotic CED-3 Caspase Functions in C. elegans. Benjamin Weaver.
W453 - 4:30 Two new genes regulate LIN-28 in the juvenile-to-adult transition. Karin Kiontke.
W454 - 4:45 The Argonaute VSRA-1 Regulates Gene Expression through Multiple Small RNA Pathways. Julie Claycomb.
W455 - 5:00 ALG-5 interacts with a subset of miRNAs to affect male gene expression and fecundity in C. elegans. Taiowa Montgomery.
W456 - 5:15 A continuum of mRNP complexes in embryonic miRNA-mediated silencing. Thomas Duchaine.
W457 - 5:30 Toward an understanding of cooperative miRNA-mediated silencing. Mathieu Flamand.
W458 - 5:45 Germline- and soma-specific mechanisms of heritable epigenetic silencing at an endogenous locus. Olga Minkina.
Saturday, July 16 4:00 PM – 6:00 PM
Palms Ballroom Canary 2
Cell Biology, Morphogenesis, and Development
| Co-Moderators: | Judith Van Houten, University of Vermont, Burlington, and Chad Pearson, University of Colorado Aurora |
Theme: Development and Morphogenesis
C62 - 4:00 Organ sculpting in the Drosophila ovary. David Bilder.
C63 - 4:30 Answer to the Puzzle: Why Paramecium Pawn Mutants Cannot Swim Backward. Judith Van Houten.
C64 - 4:45 Mitochondrial contributions to behavioral and developmental phenotypes in Paramecium tetraurelia. Wade Bell.
C65 - 5:00 Role of Aurora Kinases in Single-Cell Regeneration of Stentor. Athena Lin.
C66 - 5:15 Transcriptional dynamics of single-cell regeneration in the ciliate Stentor coeruleus. Pranidhi Sood.
C67 - 5:30 Quantifying HAP2-mediated cellular fusion in a sexual ciliate. Jennifer Pinello.
C68 - 5:45 The Role of Extracellular Microvesicles During Conjugation in Tetrahymena thermophila. Eric Cole.
Saturday, July 16 4:00 PM – 6:00 PM
Crystal Ballroom G1
Rosa Beddington Lecture
Stem Cells
| Moderator: | Yumiko Saga, National Institute of Genetics, Japan |
Theme: Stem Cell, Regeneration and Germline
M304 - 4:00 Rosa Beddington Lecture: Single cells get together: cell lineage specification & tissue morphogenesis in the early mouse embryo. Anna-Katerina Hadjantonakis.
M305 - 5:00 Snai1 is required for stem cell maintenance in the mouse intestinal epithelium. Helen Abud.
M306 - 5:15 Muscle fiber signaling scales the myogenic stem cell pool. Christoph Lepper.
M307 - 5:30 Plasticity, self-renewal and transcriptional dynamics – How embryonic stem cells stall for time in the decision making process? Joshua Brickman.
Saturday, July 16 4:00 PM – 6:00 PM
Crystal Ballroom J1, K-L
Complex Trait Evolution
| Moderator: | Dmitri Petrov, Stanford University, CA |
Theme: Evolution and Quantitative Biology
P374 - 4:00 An Ion-channel Gene Causes Natural Courtship Song Variation in Drosophila. Yun Ding.
P375 - 4:15 Allelic variation of an EXOCYST subunit switches between distinct root system architectures. Wolfgang Busch.
P376 - 4:30 Large scale splicing QTL analysis of cancer genomes. Kjong-Van Lehmann.
P377 - 4:45 QTL mapping for hitchhiking behavior in C. elegans reveals evolutionary trade-off between dispersal and reproduction. Daehan Lee.
P378 - 5:00 Genetic Analysis of Maize Lines Tolerance to Drought and Soil-Nitrogen Stresses. Bashir Bello.
P379 - 5:15 Systems genetics in Maize: A multilevel analysis of Maize response to Ozone. Lauren McIntyre.
P380 - 5:30 Deep sequencing of whole transcriptomes across the Drosophila Genetic Reference Panel. Logan Everett.
P381 - 5:45 Steps toward reproducible research. Karl Broman.
Saturday, July 16 4:00 PM – 6:00 PM
Grand Ballroom 7A
Models of Human Disease
| Moderator: | Liz Patton, Inst for Genetics and Molecular Medicine, UK |
Theme: Disease Models and Aging
Z633 - 4:00 GDF6-induced BMP signaling promotes melanoma progression by reawakening a pro-survival neural crest identity. Craig Ceol.
Z634 - 4:15 Humanising the zebrafish liver shifts metabolic profiles, improves pharmacokinetics of CYP3A4 substrates and couples with development of fluorescent screening biomarkers. Tom Carney.
Z635 - 4:30 Missing heritability for orofacial clefing identified through dissection of the gene regulatory network governing zebrafish periderm differentiation. Robert Cornell.
Z636 - 4:45 Linking cilia motility and cerebrospinal fluid flow to the etiopathogenesis of adolescent idiopathic scoliosis. Daniel Grimes.
Z637 - 5:00 Macrophage epithelial reprogramming underlies mycobacterial granuloma formation and promotes infection. Mark Cronan.
Z638 - 5:15 Metabolic stress induces Ripk3- and macrophage-dependent β-cell death in a zebrafish model of insulin resistance. Wenbiao Chen.
Z639 - 5:30 Genetically encoded apolipoprotein reporters illuminate lipoprotein dynamics in the larval zebrafish. Steven Farber.
Z640 - 5:45 Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2. Ellen Hoffman.
Saturday, July 16 7:30 PM – 9:30 PM
Grand Ballroom 8A
Plenary Session 3: Development and Disease
| Co-Moderators: | Tamara Mikeladze-Dvali, The Ludwig-Maximilians University of Munich, Germany, and Xantha Karp, Central Michigan University, Mount Pleasant |
Theme: Development and Morphogenesis
Presentations:
W459 - 7:30 The not so simple regulation of a simple cell death. Barbara Conradt.
W460 - 8:10 PP1β controls ZYG-1 levels to ensure precise centrosome doubling. Jyoti Iyer.
W461 - 8:35 Sumoylation and desumoylation in epidermal morphogenesis. Limor Broday.
W462 - 9:00 Conserved TRPA1-Nrf2 signaling mediates reactive alpha-dicarbonyl detoxification relevant for diabetic pathologies. J. Chaudhuri.
Saturday, July 16 7:30 PM – 9:30 PM
Palms Ballroom Canary 2
Community Resources: Current and Future Needs
| Co-Moderators: | Naomi Stover, Bradley University, Peoria, IL, and Doug Chalker, Washington University in St. Louis, MO |
Theme: New Technology and Resources
C69 - 7:30 TetraMine and Web Apollo at Tetrahymena Genome Database. Naomi Stover.
C70 - 7:45 TetraExpress™: A Breakthrough Protein Expression Technology. Janna Bednenko.
C71 - 8:00 Construction of a Gateway fluorescent tagging plasmid system for integration into the btu1-1 locus. Jeremy Tee.
- 8:15 Future of Ciliate Research: opportunities, needs and challenges. Panel discussion with Wei Meio, Naomi Stover, and other representatives from Ciliate Genome Databases, The Tetrahymena Stock Center, and the Tetrahymena Research advisory Board.
Saturday, July 16 7:30 PM – 9:30 PM
Palms Ballroom Sago
Immunity and Pathogenesis
| Co-Moderators: | Nathalie Franc, The Scripps Research Institute, and Pr. Jean-Marc Reichhart, IUF-UdS , and Dali Ma, Institute de Génomique Fonctionnelle de Lyon |
Theme: Disease Models and Aging
D222 - 7:30 Hemocytes as key regulators of respiratory system immunity in adult Drosophila melanogaster. Katja Brückner.
D223 - 7:45 Modulation of occluding junctions alters the hematopoietic stem cell microenvironment to trigger immune activation in Drosophila. Rohan Khadilkar.
D224 - 8:00 The TEAD family transcription factor Scalloped regulates blood progenitor maintenance and proliferation in Drosophila through PDGF/VEGFR receptor (Pvr) signaling. Julian Martinez-Agosto.
D225 - 8:15 Microbial modulation of host lipid metabolism: lessons from Drosophila. Chun Nin (Adam) Wong.
D226 - 8:30 A GWAS Analysis of Genetic Variation in Drosophila melanogaster Pathogen Susceptibility. Jonathan Wang.
D227 - 8:45 Invasion dynamics in the fly gut microbiome. Benjamin Obadia.
D228 - 9:00 Molecular analyses of immune-suppressive virus-like particles from a Drosophila parasitic wasp suggest cell-specific activities and a hybrid biotic particle nature. Mary Ellen Heavner.
D229 - 9:15 Host-produced Eiger/TNF and the bacterial type 4 secretion system enable susceptibility of Drosophila melanogaster to Coxiella burnetii infection. Alan Goodman.
Saturday, July 16 7:30 PM – 9:30 PM
Palms Ballroom Sabal
Neurophysiology and Behavior
| Co-Moderators: | Ron Davis, Scripps Research Institute, and Krystyna Keleman, Janelia Research Campus, HHMI, and Jacob Berry, Scripps Research Institute |
Theme: Neuroscience, Systems to Molecules
D230 - 7:30 Postprandial sleep mechanics in Drosophila. Keith Murphy.
D231 - 7:45 A novel behavioural paradigm of interval timing in Drosophila. Woo Jae Kim.
D232 - 8:00 Scribble Scaffolds a signalosome for active forgetting. Isaac Cervantes Sandoval.
D233 - 8:15 The detection of bitter and sweet compounds by the evolutionarily conserved sweet clade in Drosophila. Arun Kumar.
D234 - 8:30 A peptidergic pathway critical to satiety responses in Drosophila. Soohong Min.
D235 - 8:45 A genetically tractable platform for identifying regulators of acute and chronic pain. Seol Hee Im.
D236 - 9:00 The molecular and cellular basis of pharyngeal taste in Drosophila. Yu-Chieh Chen.
D237 - 9:15 Ionotropic Receptors mediate thermo- and hygro-sensation in Drosophila. Paul Garrity.
Saturday, July 16 7:30 PM – 9:30 PM
Palms Ballroom Royal
Stem Cells
| Co-Moderators: | Tor Erik Rusten, Oslo University Hospital, and Daniela Drummond-Barbosa, Johns Hopkins Bloomberg School of Public Health, and Ming-Chia Lee, Ph.D., Carnegie Institution for Science |
Theme: Stem Cell, Regeneration and Germline
D238 - 7:30 A Potential Role for DNA Replication in Establishing Distinct Epigenomes. Matthew Wooten.
D239 - 7:45 Sensing Respiratory Gases for the Control of the Hematopoietic System. Bumsik Cho.
D240 - 8:00 Opposite temporal gradients of Imp and Syp govern senescence of neural stem cells via distinct effectors. Ching-Po Yang.
D241 - 8:15 A Transcriptional Network Specifies The Intestinal Stem Cell Fate In Drosophila Adult Midgut. Qing Lan.
D242 - 8:30 Niche Appropriation by Drosophila Intestinal Stem Cell Tumors. Parthive Patel.
D243 - 8:45 The niche ligand-receptor directly orients the spindle in Drosophila male germline stem cells. Cuie Chen.
D244 - 9:00 Somatic cell encystment promotes abscission in germline stem cells after a regulated block in cytokinesis. Kari Lenhart.
D245 - 9:15 An intercellular E-cadherin-EGFR relay maintains organ size during renewal by coupling cell division and death. Jackson Liang.
Saturday, July 16 7:30 PM – 9:30 PM
Crystal Ballroom J1, K-L
PEQG Keynote 3
| Moderator: | Bret Payseur, University of Wisconsin, Madison |
Theme: Evolution and Quantitative Biology
Presentations:
P382 - 7:30 Genomics of parallel local adaptation to serpentine and toxic copper mine soils in the wildflower Mimulus. John Willis.
P383 - 8:00 Domestic pigeon's checkered past: a link between color patterning, introgression, and hereditary blindness. Anna Vickrey.
P384 - 8:15 Whole genome sequencing studies of speciation and selection in the Lake Malawi cichlid radiation. Richard Durbin.
P385 - 8:30 How much do chromosomal inversions prevent gene conversion and interspecies gene flow? Katharine Korunes.
P386 - 8:45 Convergent evolution of regulatory regions in flightless birds. Timothy Sackton.
P387 - 9:00 Genomic imprinting and speciation in mammals. Jeffrey Good.
P388 - 9:15 Cryptic genetic variation and the evolution of complex traits. Annalise Paaby.
Saturday, July 16 7:30 PM – 9:30 PM
Crystal Ballroom G2
Ira Herskowitz Award: Lars Steinmetz and Scientific Sesssion Structural and Cellular Organization
| Moderator: | Dan Gottschling, Calico Labs, South San Francisco, CA |
Theme: Neuroscience, Systems to Molecules
Y519 - 7:30 Ira Herskowitz Award. Lars Steinmetz.
Y520 - 8:00 The yeast polo kinase, Cdc5, inhibits cell growth and affects nuclear morphology during a mitotic arrest. Alison Walters.
Y521 - 8:15 Reconstitution of the microtubule nucleation system of Candida albicans. Elmar Schiebel.
Y522 - 8:30 Capture-shrinkage of astral microtubules by budding yeast dynein in cells lacking cortical endoplasmic reticulum tethering proteins Scs2 and Scs22. Wei-Lih Lee.
Y523 - 8:45 Role of the microtubule cytoskeleton in the regulation of Cdc42 dynamics. Marbelys Rodriguez Pino.
Y524 - 9:00 Spindle pole body assembly into the nuclear envelope in budding and fission yeast. Sue Jaspersen.
Y525 - 9:15 Investigating the Role of Septin Phosphorylation in Controlling of Septin Organization at Cytokinesis. Molly McQuilken.
Saturday, July 16 7:30 PM – 9:30 PM
Grand Ballroom 7B
Haematopoiesis and Vascular Biology
| Moderator: | Jill de Jong, The University of Chicago, IL |
Theme: Development and Morphogenesis
Z641 - 7:30 Macrophage-mediated thrombus dissolution is rate limiting during vascular repair. Hilary Clay.
Z642 - 7:45 A story in translation: Phosphoinositide signaling and angiogenesis. Brant Weinstein.
Z643 - 8:00 LSD1-dependent shutdown of etv2 promotes hematopoietic differentiation in hemangioblasts. Makoto Kobayashi.
Z644 - 8:15 foxc1a and foxc1b exhibit distinct compensatory requirements during brain and trunk angiogenesis and haematopoietic stem cell formation in zebrafish. Zhen Jiang.
Z645 - 8:30 Embryonic hematopoiesis in vertebrate somites gives rise to definitive hematopoietic stem cells. Anming Meng.
Z646 - 8:45 RUNX1-independent development of HSC and definitive hematopoiesis in zebrafish. Erica Bresciani.
Z647 - 9:00 TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. Weijun Pan.
Z648 - 9:15 Structural basis of endothelial Adgra2/Reck complex activity during Wnt7-dependent brain angiogenesis and blood-brain barrier formation in zebrafish. Naguissa Bostaille.
Saturday, July 16 7:30 PM – 9:30 PM
Grand Ballroom 7A
Cell Biology and Polarity
| Moderator: | Mary Mullins, Univ. of Pennsylvania |
Theme: Intracellular Dynamics
Z649 - 7:30 Microtubule-actin crosslinking factor (Macf1) Function in Oocyte Polarity and Nuclear Positioning. Matias Escobar-Aguirre.
Z650 - 7:45 Actr10, a component of the dynactin complex, regulates retrograde mitochondrial transport in axons. Catherine Drerup.
Z651 - 8:00 Apoptotic cartilage remodelng requires Kinesin I. Adrian Santos.
Z652 - 8:15 Protocadherin18a organizes notochord formation by regulating E-cadherin-mediated cell migration. Bernadett Bösze.
Z653 - 8:30 RGMa/Neogenin signaling promotes neural convergence by enhancing cell polarity and organizing microtubules. Sharlene Brown.
Z654 - 8:45 Hippo signaling regulates ventricle morphogenesis via Taz-dependent activation of Wnt and Notch signaling. Lyndsay Selland.
Z655 - 9:00 The Joubert syndrome protein INPP5E controls ciliogenesis by regulating phosphoinositides at the apical memebrane. Ying Cao.
Z656 - 9:15 An unexpected influence of the extracellular matrix on cilia function in zebrafish. Ellen LeMosy.
Sunday, July 17 7:55 AM – 8:00 AM
Palms Ballroom Sago/Sabal/Royal
Poster Awards Presentation
| Moderator: | Nancy Bonini, University of Pennsylvania, Philadelphia |
Presentations:
D246 - 7:55 Poster Awards Presentation. Ross Cagan.
Sunday, July 17 8:00 AM – 10:00 AM
Palms Ballroom Canary 2
Ciliates in the Classroom and Undergraduate Ciliate Research Symposium
| Co-Moderators: | Emily Wiley, Claremont McKenna College, and Joshua Smith, Missouri State University |
Theme: New Technology and Resources
Ciliate biologists have a long history of using the model system to engage undergraduates in their science courses. This workshop will serve as a forum for sharing innovative uses of ciliates to foster original inquiry or enhance conceptual learning in undergraduate classrooms.
- 8:00 Discussion - Integration of Research Priorities in to the Classroom.
- 8:30 Gene expression in Paramecium as a response to DNA damage. Rainey Stewart.
C72 - 8:45 Cas9 localization in the binucleated ciliate Tetrahymena thermophila. Kelsey Fryer.
C73 - 9:00 Research and Cloning of Tetrahymena thermophila UBE2S in an Introductory Science Lab. Emily Schmoll.
C74 - 9:15 Characterization of the SIRT2 and SIRT3 homologs in Tetrahymena thermophila. Kyle Cook.
C75 - 9:30 Gene expression changes during infection of Paramecium caudatum by Holospora undulata bacteria. Catherine Kagemann.
- 9:45 Towards the Identification of Genomic Targets of MED 31 in Tetrahymena thermophila. Cristina ThuppuMudalige.
Sunday, July 17 8:00 AM – 10:00 AM
Palms Ballroom Sago/Sabal/Royal
Drosophila Plenary Session
| Moderator: | Nancy Bonini, University of Pennsylvania, Philadelphia |
Presentations:
D247 - 8:00 Coordination of neuroepithelial specification and neurogenesis modes in the Drosophila visual system. Iris Salecker.
D248 - 8:30 Growth coordination mechanisms during Drosophila development. Pierre Leopold.
D249 - 9:00 Networking at the nuclear periphery: Contributions of Drosophila LEM domain proteins. Pamela Geyer.
D250 - 9:30 Molecular genetics of sex-specific evolutionary innovations. Artyom Kopp.
Sunday, July 17 8:00 AM – 10:00 AM
Crystal Ballroom G1
Human Disease Models II
| Co-Moderators: | Teresa Gunn, McLaughlin Research Institute, Great Falls, MT, and Clare Smith, University of Massachusetts Medical School, Worcester, MA |
Theme: Disease Models and Aging
M308 - 8:00 Comparative Mendelian genomics and disease modeling in mice. Laura Reinholdt.
M309 - 8:15 A New Mouse Model for Costello Syndrome. Tania Sorg.
M310 - 8:30 A genetic epistasis analysis of an ENU-induced Reln mutant reveals that the C-terminal domain of RELN is required for binding to the receptor VLDLR but not to LRP8 (APOER2). David Beier.
M311 - 8:45 Inhibition of activin A stops the regrowth of surgically resected heterotopic bone in a mouse model of Fibrodysplasia Ossificans Progressiva and indicates a new potential path to therapy. Aris Economides.
M312 - 9:00 Driving discovery and characterisation of novel genes important for bone biology by combining high-throughput mouse phenotyping and a tissue-based deep phenotyping platform. Chris Lelliott.
M313 - 9:15 From mouse to human and back to mouse: sodium channel mutations and epilepsy. Miriam Meisler.
M314 - 9:30 Cas9 RNA-guided nuclease gene editing – rapid disease modeling in mice. Lauryl Nutter.
- 9:45 Trainee Awards.
Sunday, July 17 8:00 AM – 10:00 AM
Crystal Ballroom J1, K-L
Epistasis
| Moderator: | Michael Lynch, Indiana University, Bloomington |
Theme: Evolution and Quantitative Biology
Presentations:
P389 - 8:00 Dissecting the large X-effect in Drosophila speciation: high resolution mapping and the identification of hybrid male sterility genes. Colin Meiklejohn.
P390 - 8:15 The naturally variable ELF3 polyglutamine is the hub of an epistatic network in Arabidopsis thaliana. Maximilian Press.
P391 - 8:30 Functional compensation and dependency between duplicated genes in protein interaction networks. Christian Landry.
P392 - 8:45 High-throughput measurements of the evolutionary consequences of epistasis. José Rojas Echenique.
P393 - 9:00 Beyond candidate genes: Mapping monogenic trait modifiers using informative recombinant progeny in yeast. Amy Sirr.
P394 - 9:15 Characterizing patterns of epistasis in yeast experimental evolution. Gregory Lang.
P395 - 9:30 Genetic Interactions Suppress Extreme Bone and Weight Phenotypes in a Mouse Intercross. Gregory Carter.
P396 - 9:45 Can epistasis or GxE be predictable? Lessons from mitonuclear interactions in Drosophila. David Rand.
Sunday, July 17 8:00 AM – 10:00 AM
Crystal Ballroom G2
The Fat and Sweet Sides of Life
| Moderator: | Karl Kuchler, Medical University Vienna, Austria |
Theme: Neuroscience, Systems to Molecules
Y526 - 8:00 The respiration/fermentation switch in yeast requires protein aggregation. Kobi Simpson-Lavy.
Y527 - 8:15 SNX-BAR proteins contribute to autophagy via trafficking of lipids required for autophagosome-vacuole fusion. Richard Chi.
Y528 - 8:30 Rewiring of lipid metabolism in a yeast mutant devoid of the major membrane lipid phosphatidylcholine. Anton de Kroon.
Y529 - 8:45 The lysine acetyltransferase complex NuA4 regulates cellular phosphatidylinositol-4-phospahate and phospholipid metabolism. Louis Dacquay.
Y530 - 9:00 An unexpected role for casein kinases in glucose sensing and signaling. Chris Snowdon.
- 9:15 Poster Awards.
Sunday, July 17 8:00 AM – 10:00 AM
Grand Ballroom 7A
Genome Editing
| Co-Moderators: | Bettina Schmid, DZNE, Munich, Germany, and Darius Balciunas, Temple University, PA |
Theme: New Technology and Resources
Z657 - 8:00 A High-Throughput workflow for CRISPR/Cas9 mediated targeted mutagenesis to model human disease genes in zebrafish . Gaurav Varshney.
Z658 - 8:15 Resource Construction at the China Zebrafish Resource Center. Yong-Hua Sun.
Z659 - 8:30 Phenome-scale screen defines post-embryonic gene function during the zebrafish larval-to-adult transition. Ricardo Fuentes.
Z660 - 8:45 Precise editing of the zebrafish genome by homologous recombination made simple and efficient. Kazuyuki Hoshijima.
- 9:00 Workshop and Roundtable.Bettina Schmid Ben Feldman (poster Z6083) Ann Davidson (poster Z6152) Darius Balciunas Annekatrien Boel (posters Z6079 & Z6089) Jeff Essner Uwe Irion.
Sunday, July 17 10:30 AM – 12:30 PM
Palms Ballroom Sago/Sabal/Royal
Technology and its Applications Joint Plenary Session
| Moderator: | Phil Hieter, University of British Columbia |
Presentations:
J9 - 10:30 The gut microbiota and childhood undernutrition: looking at human development from a microbial perspective. Jeffrey Gordon.
J10 - 11:00 Synthesis of the yeast genome and beyond. Jef Boeke.
J11 - 11:30 Tomorrow’s Table: Organic Farming, Genetics and the Future of Food. Pamela Ronald.
J12 - 12:00 CRISPR-Cas Genome Engineering: Biology, Technology and Ethics. (pre-recorded talk). Jennifer Doudna.